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ANALGESIA
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Dynamic weight bearing : New incapacitance test
Click here to maximize 		Dynamic weight bearing : New incapacitance test
(Model: DWB-M - For mice)

Measuring the Postural Equilibrium (weight bearing) on freely moving Mice or Rats - an efficient alternative to traditional incapacitance tests for your research on analgesia/nociception.

- Publications - Technical specifications - Others products / accessories -
 
Download PDF Download video Send a link to this page to a friend
    Presentation
    Weight Bearing of rodents, also named « incapacitance » test, is well known in nociceptive research studies. Traditional « static » type instruments have been used in the last years for assessing pain sensitivity.

    Those static incapacitance instruments, although showing well correlated results vs paw pressure vocalization test, calibrated Von Frey filaments, etc, (cf Richebe P, Laulin JP, Simonnet G, Anesthesiology 2005, Pain 2007,...), are highly dependant on the animal (rat or mouse) positionning inside a stressfull restrainer. This makes them time consuming and difficult to use particularly when large number of rodents are considered.

    Operation principle
    Bioseb has now developped the Dynamic Weight Bearing Test, a new type of incapacitance test with a floor instrumented cage , allowing to measure independantly the weight bore by each limb of a free moving animal (mouse or rat). The system accuracy and resolution are insured via a metrological calibration performed prior to the data capture. During the data capture, the raw datas for each paw are synchronized with the images from a video camera and the averaged values are encrypted and recorded on a pc (via an usb link) with a sampling rate of 10 Hz, providing you with valuable data for your research on nociception/analgesia. This instrument is especially suitable for research on Parkinson and Alodynia.

    Analysis and replay can be performed on site or remotely. During the analysis and replay, the operator can check and secure each limb recognition.
    The weight distribution of the animal (rat or mouse), per limb, is then shown in the result window, for each time period with the mean and the variation coefficient.


    Click to enlarge pictures


    !New! Publication

    Bioseb team presents its respectful thanks to following research teams who used the Dynamic Weight Bearing during their recent studies:

    • Team of Prof. Doré-Savard (University of Sherbrooke, Sherbrooke, Québec, Canada)
    Imaging, Behavioural and Neurochemical Characteristics of a Clinically Relevant Bone Cancer Pain Model, by Louis Doré-Savard, Valérie Otis, Luc Tremblay, Karine Belleville, Mélanie Archambault et al.
    (Click here to send a download request for this research poster as a PDF file)

    • Team of Prof. Roussy (University of Sherbrooke, Sherbrooke, Québec, Canada)
    Improving Pain Assessment In A New Mouse Model Of Bone Cancer Pain, by G. Roussy, K. Belleville, N. Beaudet and P. Sarret
    (Click here to send a download request for this research poster as a PDF file)

    • Team of Prof. Tétreault (University of Sherbrooke, Sherbrooke, Québec, Canada)
    NTS2 receptor activation as an innovative target for the treatment of neuropathic pain, by P.G. Tétreault, A. Guillemette, K. Belleville, J. Martinez, N. Beaudet and P. Sarret
    (Click here to send a download request for this research poster as a PDF file)


    Click on a picture to send a download request for a research poster

Technical specifications (Click here to see our "Information Liability Disclaimer")

Overall Dimensions (Lx W x H cm) For mice: 17 x 17 x 22
For rats: 30 x 30 x 35
Weight kg For mice: 1kg
For rats: 2,5kg
Power supply from PC USB port
Animal Cage Internal dimensions
(Lx W x H cm)		 For mice: 11 x 11 x 22
For rats: 22 x 22 x 30
Sensor Accuracy / Resolution / range (in gram) For mice: 1 / 0,2 / 15 – 50
For rats: 3 / 0,8 / 150 – 500
Delivered with Cage, 1 sensor, usb interface, webcam, software DynInc
Wearing Part Sensor
Materials : Cage:Floor Grey ppc
Walls & Top Cover:Transparent ppc
Software DynInc Allows to measure the weight bore on each limb, averaged. Raw datas encrypted (glp) and recorded with sampling rate =10Hz with video recording (synchronous).
Replay : at any time.
Results: .xls type, presented per limb & time period, mean & variation coefficient
Software requirement PC 2 GO Ram, fast processor, Windows XP/vista, 3x USB port, supplied with : interface, webcam , mini usb cable.
Option Extra sensor

Model:
DWB-M
Dynamic weight bearing : New incapacitance test
For mice Contact us

Linked products:
BIO-SWB
Static weight bearing: Incapacitance Test
Contact us
DWB-M
Dynamic weight bearing : New incapacitance test
For mice Contact us
DWB-R
Dynamic weight bearing : New incapacitance test
For rats Contact us
Print version Handbook
(PDF format)
Instrument's tutorial
Instrument's FAQ
 Demonstration
video 		Click to order

Bioseb

Tél :+33 (0)820 825 523
Fax :+33 (0)820 825 521
E-Mail :info@bioseb.com

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