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Tail Suspension Test
BIOSEB' Tail Suspension Test system is the only full automatic test in the world!
It is a fast and reliable way for testing psychotropic effets of drugs (anti-depressants,sedatives).
- PORSOLT AND PARTNERS Boulogne, France
- INSTITUT DE RECHERCHE SERVIER Croissy sur Seine, France
- INSERM Paris, Creteil, France
- HOWARD FLOREY INSTITUTE Melbourne, Australia
- NOVARTIS Basel, Switzerland
- ROCHE Basel, Switzerland
- GLAXO SMITH KLINE UK
- HELMHOLTZ ZENTRUM MÜNCHEN Neuherberg, Germany
- GEDEON RICHTER Budapest, Hungaria
- CENTER OF MENTAL HEALTH Mannheim,Germany
- UNIVERSITY OF NANTES Nantes, France
- CNRS Valbonne, Bordeaux, Rouen, France
- SANOFY AVENTIS Bagneux, France
- Swiss Federal Institute of Technology Lausanne, Suisse
- UNIVERSITE PARIS SUD Chatenay Malabry, France
- INSTITUTE OF EXPERIMENTAL MEDICINE Budapest, Hongrie
- HELMHOLTZ ZENTRUM MÜNCHEN Neuherberg, Allemagne
- SERVIER Croissy sur seine, France
- INRA Bordeaux, France
- IPSEN INNOVATION Les Ulis, France
- LILLY TAIWAN
- Subchronic Alpha-Linolenic Acid Treatment Enhances Brain Plasticity and Exerts an Antidepressant Effect: A Versatile Potential Therapy for Stroke. By Blondeau N et al. In Neuropsychopharmacol., 2009.
- ) CNS Disorders—Current Treatment Options and the Prospects for Advanced Therapies. By DiNunzio JC et al. In Drug Development and Industrial Pharmacy 13:1-27, 2008.
- Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease. By MJ.Dowiea, HB.Bradshawb, ML Howardc, LFB.Nicholsond & al. In The Journal of Neuroscience456-6. 2009 Jun 10.
- Behavioural and neuroplastic effects of the new-generation antidepressant agomelatine compared to fluoxetine in glucocorticoid receptor-impaired mice. By E.Païzanisa, T.Renoira, V.Lelievrea, F.Saurinia & al. In Neuropharmacology 1-16. 2009 Sept.
- Altered serotonin receptor expression associated with depression related behav. in R6/1 transgen. mouse mod. of Huntington disease. By TYC Pang, X.Du, MS.Howard & AJ.Hannan. In Human molecular genetics 753-66. 2008 Nov 13.
- Differential long-term effects of MDMA on serontoninergic syst. & hippoc. cell prolif. in 5HTT knock-out vs. wild-type mice. By T.Renoir, E.Pazanis, ME.Yaccoubi, FA.Saurini & al. In International Journal of Neuropharmacology, Cambridge University, July 2008.
- Lasting depression Syndrome Prod. by reduct in Serotonin Uptake in postnat. dev. : Evidence from sleep, stress & behav.. By D.Popa, C.Lena, C.Alexandre, J.Adrien. In The Joural of Neuroscience 28(14):3546-3554, April 2008.
- UNIT 5.8 Rodent Models of Depression: Forced Swim and Tail Suspension Behavioral Despair Tests in Rats and Mice. By Castagné V et al. In Current Protocols in Pharmacology., 38:5.8.1-5.8.11, 2007.
- Calcineurin (protein phosphatase 2B) is involved in the mechanisms of action of antidepressants. By Crozatier C et al. In Neuroscience , 144(4):1470-1476, 2007.
- Suitability of tamoxifen-induced mutagenesis for behavioral phenotyping. By Vogt MA et al. In Experimental Neurology, 211(1):25-33, 2007.
- Early Life Blockade of 5-Hydroxytryptamine 1A Receptors Normalizes Sleep and Depression-Like Behavior in Adult Knock-Out Mice Lacking the Serotonin Transporter. By Alexandre C et al. In J. Neurosci., 26(20): 5554-5564, 2006.
- IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors. By Chourbaji S et al. In Neurobiology of Disease ,23(3):587-594, 2006.
- Estrous cycle effects on behavior of C57BL/6J and BALB/cByJ female mice: implications for phenotyping strategies. By Meziane H et al. In Genes, Brain and Behavior, 6(2):192-200, 2006.
- Fluoxetine effects in a new transgenic model of depression By E.Païsanis, L.Lanfumey & al. In Posters (French) P2T Pharmacology and Physiology Association meeting, April 2006
- The Tail Suspension Test As A Model For Assessing Antidepressant Activity: Review Of Pharmacological And Genetic Studies In Mice. By Cryan, Mombereau and Vassout. In Neuroscience & Biobehavioral Reviews ;29(4-5):571-625 (2005)
- Stress-Induced Anhedonia in Mice is Associated with Deficits in Forced Swimming. By Strekalova, Spanagel & al. In Neuropsychopharmacology (2004) 29
- Genetic and Pharmacological Evidence of a Role for GABAB Receptors in the Modulation of Anxiety- and Antidepressant-Like Behavior By Mombereau & al. In Neuropsychopharmacology (2004) 29
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Presentation
The Tail Suspension Test was described in the 80's by Steru & al. and allows for fast evaluation of drugs (anti-depressants,sedatives) psychotropic effects.
The measuring principle is based on the energy developed by a mouse trying to escape from its suspension. During the Tail Suspension Test, the movements of the mice are analyzed in terms of force, energy and power developed over time. As human observation is time consuming and tedious, Bioseb's Tail Suspension Test (TST) automates the entire experiment.
The Bioseb Tail Suspension Test instrument includes unique features such as the randomization process of the animals, the measurement of up to 6 animals in the same run, the direct computations of the "Immobility", the "ENERGY" and the "Power in Motion". Settings are available to adjust the definitions to user's protocol.The energy value is a unique way to differentiate between passive swinging and active struggling.
How does it works ?
Although alternative techniques, as video tracking, can be used to measure the "immobility" periods of the mice, the energy cannot be quantified in this way.The only way to quantify properly the energy, or the power, spent by the animal trying to escape, is the use of specific strain gauges.We offer a complete and easy to set up solution, including the hardware and the software with a sampling rate of up to 1000 Hz. Results are displayed in real time, and 2 levels of analysis are available in the system. Direct measurements are displayed for the 3 parameters (Immobility, Energy, Power in motion) and a second level opens access to the recorded raw data graphs and values for in depth analysis. As all experiments are recorded, they can be replayed at any time.
Specifications:
Running under windows XP for added reliability, the software is
flexible for the researcher and user friendly :
• Just one screen is needed to set up all the parameters (number of animals, thresholds, start of measuring period, end of measure ...).
• "Randomization" module to define the rank of the different "dosed" animals in their groups.
• During the test: Bargraph displays energy and realtime computation of results.
• Results: immobility time, energy value, power during the mobility period. They are displayed on graphs and numerical tables.
• Experiment directory is created automatically to store the different files relating to the experiment.
• Original Data files are saved and protected as GLP compatible.
• Results are either printed or stored in .at ocxls files formats.
• Replay of past experiments is always possible, allowing to test different parameters for the experhent.
• It is also possible to discard the result of a particular animal (for example if the subject falls down during the test), in such a case the traceability and the experiment would be secured.
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THE INFORMATION IN THIS WEB SITE AND IN LINKED PAGES AND DOCUMENTS IS PROVIDED "AS IS" AND DOES NOT CREATE ANY EXPRESS OR IMPLIED WARRANTY ABOUT BIOSEB OR ITS PRODUCTS OR SERVICES.
Information published on this Web Site as well as services, product specifications, availability and prices are subject to change without notice. BIOSEB may also make improvements and/or changes in the products and/or the programs described in this Web Site at any time without notice.
BIOSEB has made reasonable efforts to verify that the information in this Web site was accurate when first published. Such information may contain errors or omissions, however, and it is subject to change without notice. Bioseb does not undertake to update this information to include any such changes or to correct errors or omissions. Bioseb assumes no responsibility for any use of the information in this Web site or for any infringement of patents or other rights of third parties that may result. Certain information may be country-specific and may not apply in all countries.
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Channels |
2x 3 channels max.
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Windows plateform |
Windows XP
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Acquisition |
1000 Hz
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Analysis |
Software with settable thresholds
Export possibilities to MS-Excel |
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Model:
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Bioseb
Tél :+33 (0)820 825 523 Fax :+33 (0)820 825 521
E-Mail : info@bioseb.com
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