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BIOSEB DEVELOPMENT |
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Grip strength test
An easy way to quantify objectively rodents muscular strength, the effect of drugs, toxins, disease, nerve damage. This force assesment is widely used in conjonction with the ROTAROD motor coordination test, as a normally coordinated subject will show a low score if its muscular strength is low.
- HARVARD MEDICAL SCHOOL Charlestown, Etats-Unis
- NIH Rockville, Etats-Unis
- MOREHOUSE SCHOOL OF MEDICINE Atlanta, Etats-Unis
- UCSF-GALL0 CENTER Emeryville, Etats-Unis
- UNIVERSITY OF SOUTH FLORIDA Tampa Frorida, Etats-Unis
- UNIVERSITY OF GEORGIA Georgia, Etats Unis
- CORIMMUN GMBH Martinsried, Allemagne
- TAKEDA CAMBRIDGE Cambridge, Grande Bretagne
- UNIVERSITY OF MARYLAND Baltimore, Etats Unis
- UNIVERSITY OF MISSOURY Missoury, Etats-Unis
- ABBOTT GMBH & KO Ludwigshafen, Allemagne
- WELLCOME TRUST SANGER INSTITUTE Cambridge, Royaume Unis
- UNIVERSITY OF EDINBURGH Edinbourg, Royaume-Unis
- ADDEX PHARMACEUTICALS Archamps, France
- HELMHOLTZ ZENTRUM MÜNCHEN Munich, Allemagne
- BIOCODEX Compiegne, France
- UPRES Marseille, France
- MDS PHARMA St Germain sur L'Arbresle, France
- ECOLE VETERINAIRE ALFORT Maison Arfor, France
- GUERICKE UNIVERSITY Magdeburg, Allemagne
- FACULTE DE MEDECINE Namur, Belgique
- LAB RESEARCH Veszprem, Hongrie
- NEURAXO BIOPHARMACEUTICALS Dusseldorf, Allemagne
- INSERM Grenoble, Suisse
- HARWELL SCIENCE AND INNOVATION Didcot, Royaume Unis
- NOVARTIS Balle, Suisse
- LAB DE NEUROPHYSIOLOGY Bruxelle, Suisse
- IGBMC Srasbourg, France
- ICS Strasbourg, France
- COLLEGE DE France Paris, France
- PHARMACOLGIE Clermont-Ferrand, France
- MDS L’ARBRESLE
- UNIVERSITE LOUIS PASTEUR Strasbourg, France
- IPSEN BEAUFOURLes Ulis,France
- GENEVA UNIVERSITY PHARMACOLOGY Geneve, Suisse
- ERAMUS UNIVESITY ROTTERDAM Rotterdam, Pays bas
- INSERM Paris, France
- JAGIELLOXIAN UNIVERSITY Cracovie, Pologne
- INSERM Nantes, France
- TROPHOS Marseille, France
- BAYER CROP SCIENCE Nice, France
- CNRS Paris, Strasbourg, Nantes, Orleans, Clermont-Ferrand, Orsay, Yvette & Marseille, France
- FAUST PHARMACEUTICALS Illkrich, France
- PIERRE FABRE Castres & Tours, France
- EMBL Monterodondo, Italie
- GLAXO SK UK Ware, Royaume Unis
- PARADIGM Pharmaceutical Singapour
- EPFL Lausanne, Suisse
- NOVARTIS Basel, Suisse
- NEUROFIT Illkrich, Suisse
- SANOFI Vitry, Toulouse & Montpellier, France
- SERVIER Croissy sur Seine, France
Microglia Protect Neurons against Ischemia by Synthesis of Tumor Necrosis Factor. By KL Lambertsen, B Hjelm Clausen, AA Babcock, R Gregersen & al. In The Journal of Neuroscience 2009 Feb 04.
Mice Lacking the Extracellular Matrix Protein WARP Develop Normally but Have Compromised Peripheral Nerve Strucure and Function. By JM Allen, L Zamurs, B Brachvogel, U Schötzer-Schrehardt & al. The Journal of Biological Chemistry. 2009 Mars 11.
Pharmacodynamic & -kinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine & vigabatrin in the mouse pentylenetetrazole-induced seizure model : An isobolographic analysis. By M Dudra-Jastrzebskaa, MM Andreas-Machb, M Sielskia, N Ratnarajc & al. In European Journal of Pharmacology. 2009 Jan 11.
Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6 Hz psychomotor seizure model. By E Wojdaas, A Wlaza, PN Patsalosb & JJ Luszczkia. In Epilepsy Research 2009 Jul 10.
N-(anilionomethyl)-p-isopropoxyphenylsuccinimide potentiates the anticonvulsant action of phenobarbital and valproat in the mouse maximal electroshock-induced seizure model, By JJ Luszczkia, SL Kocharovc & SJ Czuczwara. In Journal of Neuroscience Research 2009 Jul
Muscle Mitochondrial Uncoupling Dismantles Neuromuscular Junction and Triggers Distal Degeneration of Motor Neurons, By L Dupuis, JL Gonzalez de Aguilar, A Echaniz-Laguna, J Eschbach & al. In PLoS One April 30 2009
Spironolactone potentiates the protective action of some selected antiepileptic drugs against maximal electroshockinduced seizures in mice, By J Kozinska, KM Sawicka, A Zadrozniak, E Wojda & al. In Annales UMCS, Pharmacia Volume 22
Amiloride enhance anticonvulsant action of various antiepileptic drugs in mouse max elestroschock seizure model By JJ Luszczki, KM Sawicka, J Kozinska, M Dudra-Jastrzebska & SJ Czuczwar. In Journal of Neural Transmission , 2009 Jan
Low intensity exercise attenuates disease progression and stimulates cell proliferation in the spinal cord of a mouse model with progressive motor neuronopathy By M.Ferrer-Alcon, C.Winkler-Hirt, R.Madani & al. In Neuroscience, Vol 152, issue 2, p.291-295. March 2008.
Effect of thioperamide on oxidative stress markers in middle cerebral artery occlusion model of focal cerebral ischemia in rats. By Akhtar M et al. In Human & Experimental Toxicology, 27(10):761-767; 2008.
Protective effect of aqueous extract of Embelia ribes Burm fruits in middle cerebral artery occlusion-induced focal cerebral ischemia in rats. By Bhandari U et al. In Indian J. Pharmacol, 40(5):215-220, 2008.
Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. By Luszczki JJ. In Naunyn Schmiedebergs Arch Pharmacol, 378(5):483-92, 2008.
Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study. By Mandillo S et al. In Physiol. Genomics ,34:243-255, 2008.
Amyloide precursor protein knockout mice show age-dependant deficit in pass. avoid. learning. By Y.Senechal, PH.Kelly & KK.Dv. In Behavioural Brain Research, Vol186-1, p.126. January 2008.
Wild-type PABPN1 is antiapoptotic & reduce toxic. of oculopharyng. musc. dystrophy mutation. By JE.Davies, S.Sarkar, DC.Rubinsztein. In Human Molleculat Fenetics, 17(8):1097-1108. April 2008.
Neuron-Specific Expression of mutant Superoxide Dismutase is sufficient to induce Amyotrophic lateral sclerosis in transgenic mice. By D.Jaarsma, E.Teuling, ED.Haasdijk, CI De Zeeuw & al. In The Journal of Neuroscience, 28(9):2075-2088, February 27, 2008.
uPA defi ciency exacerbates muscular dystrophy in MDX mice. By Suelves M et al. In J. Cell. Biol., 178(6):1039-1051, 2007.
Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice. By Senechal et al. In J. Neurochem, 102(6):1928-1940 , 2007.
Analysis of dopamine transporter gene expression pattern − generation of DAT-iCre transgenic mice. By Turiault M et al. In FEBS J. , 274(14):3568-3577, 2007.
Synergistic effects of caloric restriction with maintained protein intake on skeletal muscle performance in 21-month-old rats: a mitochondria-mediated pathway. By Zangarelli A et al. In The FASEB Journal ,20: 2439-2450, 2006.
Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death. By Andrieu D et al. In BMC Dev Biol., 6:56, 2006.
Dynein mutations impair autophagic clearance of aggregate-prone proteins, By B Ravikumar, A Acevedo-Arozena, S Imarisio, Z Berger, C Vacher, C J O'Kane, SDM Brown, DC Rubinsztein. In Nature Genetics 37, 771 - 776 (01 Jul 2005)
Friedreich Ataxia Mouse Models with Progressive Cerebellar and Sensory Ataxia Reveal Autophagic Neurodegeneration in Dorsal Root Ganglia, In The Journal of Neuroscience, 24(8): 1987-95, February 25 2004
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Bioseb manufactures a range of Grip Strength Testers to help determining the maximal force developped by a rodent, Rat or mouse when the operator tries to pull it out of a specialy designed grid. This test has been documented in the litterature and allows to study the neuromuscular fonctions. The measure is done using a highly accurate sensor, and with an electronic device with a sampling rate up to 1000 Hz. This ensures obviously that the ultimum maximum force is perfectly captured and displayed. Readings are expressed in grams, in Newtons, or in lbs. The unit is directly selected by the keyboard. Outputs for the datas are through RS232, printer, or graphic recorder. Individual measurements (up to 100) are stored in internal memory, and can be dowloaded post experiment
The new Bioseb GRIP TEST Version 3+ shows numerous unique features as:
Recently an embedded statistical computation, has been included in the electronic device. This is a very usefull feature that as been very well received and used by users of large numbers of tests. The displays shows in real time the mean, standard deviation and variation coefficient from groups of animals. This feature allows also to cancel any grip strength test not correctly performed.
Specifications and main functionalities of BIOSEB Grip Test:
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• NEW AND UNIQUE: internal statistical computations, a new development by Bioseb allows direct reading of the average value, standard deviation and variability for several subjects groups and up to 100 animals.
• Very fast sampling rate of 1000Hz, to secure the repeatability in the “peak” force capture and measurement
• Higly reliable sensors, with 0,2 gram accuracy at full scale and a fine resolution (resolution is user-settable as low as 0,001g)
• Internal memory for measured data, up to 100 values can be stored manually, to be edited or downloaded later on
• Datas are stored in memory as a table with time/measured force
• Built-in RS 232 port allowing transfer of data to a PC or a printer
• Optional Bioseb RSIC Software allowing to send measured values directly into a Microsoft Excel spreadsheet
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Supplied with: 1 grip (to be chosen between available models described above), RS232 cable, power supply adaptor, user manual
Special model upon request: please enquire.
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THE INFORMATION IN THIS WEB SITE AND IN LINKED PAGES AND DOCUMENTS IS PROVIDED "AS IS" AND DOES NOT CREATE ANY EXPRESS OR IMPLIED WARRANTY ABOUT BIOSEB OR ITS PRODUCTS OR SERVICES.
Information published on this Web Site as well as services, product specifications, availability and prices are subject to change without notice. BIOSEB may also make improvements and/or changes in the products and/or the programs described in this Web Site at any time without notice.
BIOSEB has made reasonable efforts to verify that the information in this Web site was accurate when first published. Such information may contain errors or omissions, however, and it is subject to change without notice. Bioseb does not undertake to update this information to include any such changes or to correct errors or omissions. Bioseb assumes no responsibility for any use of the information in this Web site or for any infringement of patents or other rights of third parties that may result. Certain information may be country-specific and may not apply in all countries.
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Sensor Capacity |
0 - 2 kG (20N) reading 1 gram.
Other capacities on request.
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Accuracy |
0,1 percent of full scale
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Data Output |
RS232 for computer, analog output for graphic recorders
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Internal memory |
100 individual values
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Overall dimensions |
400x180x200 mm for the 1 grip model
and 750 x 180 x 200 mm for the Double grip model
(can be used to measure fore + back limbs ).
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Grid and Bars |
Stainless steel, allowing sterilization, with a specific design to protect the animal paws from injuries, different grids and bars are available depending on the specie and the limbs to test.
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Example dimensions of the Mouse Grid |
100 x 80 mm, angled 20° (other on request).
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Special applications |
To measure independently right and left forelimbs, small monkeys …
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Model:
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Accessories :
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Bioseb
Tél :+33 (0)820 825 523 Fax :+33 (0)820 825 521
E-Mail : info@bioseb.com
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