An easy way to objectively quantify the muscular strength of rodents (mouse and rat), and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. This force assessment is widely used in conjunction with the ROTAROD motor coordination test, since a normally coordinated rodent will show a low score if its muscular strength is low.
Miller et al. (2010) ENU Mutagenesis Reveals a Novel Phenotype of Reduced Limb Strength in Mice Lacking Fibrillin 2. PLoS ONE 5(2):e9137 (mouse, UK)
Dudra-Jastrzebska et al. (2009) Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: An isobolographic analysis. Eur. J. Pharmacol. 605(1-3): 87-94. (mouse, Poland, UK)
Dupuis L et al. (2009) Muscle Mitochondrial Uncoupling Dismantles Neuromuscular Junction and Triggers Distal Degeneration of Motor Neurons. PLoS ONE 4(4):e5390.(mouse, France)
Kozinska J et al (2009) Spironolactone potentiates the protective action of some selected antiepileptic drugs against maximal electroshock-induced seizures in mice. Annales UMCS, Pharmacia. 22(1):123-134. (mouse, Poland)
Lambertsen KL et al. (2009) Microglia Protect Neurons against Ischemia by Synthesis of Tumor Necrosis Factor. J. Neurosci. 29(5):1319-1330. (BIO-GT3, Mouse, Denmark, Sweden).
Luszczki JJ et al. (2009) N-(anilinomethyl)-p-isopropoxyphenylsuccinimide potentiates the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock-induced seizure model Neurosci. Res. 64(3):267-272. (mouse, Poland, Armenia)
E Wojdaas, A Wlaza, PN Patsalosb & JJ Luszczkia. Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6 Hz psychomotor seizure model In Epilepsy Research 2009 Jul 10.
JJ Luszczkia, SL Kocharovc & SJ Czuczwara. N-(anilionomethyl)-p-isopropoxyphenylsuccinimide potentiates the anticonvulsant action of phenobarbital and valproat in the mouse maximal electroshock-induced seizure model In Journal of Neuroscience Research 2009 Jul
JM Allen, L Zamurs, B Brachvogel, U Schötzer-Schrehardt & al. Mice Lacking the Extracellular Matrix Protein WARP Develop Normally but Have Compromised Peripheral Nerve Strucure and Function. The Journal of Biological Chemistry. 2009 Mars 11.
Akhtar M et al. (2008) Effect of thioperamide on oxidative stress markers in middle cerebral artery occlusion model of focal cerebral ischemia in rats. Human & Experimental Toxicology. 27(10):761-767. (rat, India)
Bhandari U et al. (2008) Protective effect of aqueous extract of Embelia ribes Burm fruits in middle cerebral artery occlusion-induced focal cerebral ischemia in rats. Indian J. Pharmacol. 40(5):215-220. (rat, India)
Luszczki JJ. (2008) Amiloride enhances the anticonvulsant action of various antiepileptic drugs in the mouse maximal electroshock seizure model. J Neural Transm. 116(1):57-66. (mouse, Poland)
Davies J et al. (2008) Wild-type PABPN1 is anti-apoptotic and reduces toxicity of the oculopharyngeal muscular dystrophy mutation. Hum. Mol. Genet. 17(8):1097-1108 (mouse, UK)
Ferrer-Alcon M (2008) Low intensity exercise attenuates disease progression and stimulates cell proliferation in the spinal cord of a mouse model with progressive motor neuronopathy. Neuroscience 152(2):291-295. (Mouse, Switzerland)
Jaarsma D et al. (2008) Neuron-Specific Expression of Mutant Superoxide Dismutase Is Sufficient to Induce Amyotrophic Lateral Sclerosis in Transgenic Mice. J. Neurosci. 28(9):2075-2088 (mouse, Netherlands)
Luszczki JJ. (2008) Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. Naunyn Schmiedebergs Arch Pharmacol. 378(5):483-92. (mouse, Poland)
Luszczki JJ et al. (2008) Agmatine enhances the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock seizure model. Journal of Neural Transmission. 115(11):1485-94. (mouse, Poland)
Luszczki J et al. (2008) Effects of amlodipine, diltiazem, and verapamil on the anticonvulsant action of topiramate against maximal electroshock-induced seizures in mice. Can. J. Physiol. Pharm. 86(3):113-121 (mouse, Poland)
Luszczki J et al. (2008) Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy. Eur. J. Pharmacol. 595(1-3):13-21 (mouse. Poland)
Mandillo S et al. (2008) Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study. Physiol. Genomics 34:243-255 (LE8200, mouse, Eumorphia protocols, Germany, France, UK, Italy)
Senechal et al. (2008) Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning. Behav. Brain Res. 186(1):126-132 (mouse, Ireland)
Teuling E et al. (2008) A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice. Human Molecular Genetics. 17(18):2849-2862. (mouse, The Netherlands)
Filliat P et al. (2007) Long-term behavioral consequences of soman poisoning in mice. Neurotoxicology. 28(3):508-519 (mouse, France)
Ling et al. (2007) Behavioral and pharmacological description of oxaliplatin-induced painful neuropathy in rat. Pain. 218(3):225-234 (rat, France)
Luszczki J et al. (2007) Effects of three calcium channel antagonists (amlodipine, diltiazem and verapamil) on the protective action of lamotrigine in the mouse maximal electroshock-induced seizure model. Pharmacol. Rep. 59:672-682 (mouse, Poland)
Luszczki J et al. (2007) Imperatorin enhances the protective activity of conventional antiepileptic drugs against maximal electroshock-induced seizures in mice. Eur. J. Pharmacol. 574(2-3):133-139 (mouse, Poland)
Rouaux et al. (2007) Sodium Valproate Exerts Neuroprotective Effects In Vivo through CREB-Binding Protein-Dependent Mechanisms But Does Not Improve Survival in an Amyotrophic Lateral Sclerosis Mouse Model. J. Neurosci. 27(21):5535-5545 (mouse, France)
Sahly I et al. (2007) 5-HT1A-iCre, a new transgenic mouse line for genetic analyses of the serotonergic pathway. Mol. Cell. Neurosci. 26(1):27-35 (mouse, France)
Senechal et al. (2007) Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice. J. Neurochem. 102(6):1928-1940 (mouse, Ireland)
Suelves M et al. (2007) uPA deficiency exacerbates muscular dystrophy in MDX mice. J. Cell. Biol. 178(6):1039-1051 (Mouse, Spain)
Turiault M et al. (2007) Analysis of dopamine transporter gene expression pattern − generation of DAT-iCre transgenic mice. FEBS J. 274(14):3568-3577 (mouse, France)
Andrieu D et al. (2006) Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death. BMC Dev Biol. 6:56. (mouse, France)
Davies JE (2006) Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy. Human Molecular Genetics 2006 15(1):23-31. (Mouse, UK)
Luszczki JJ et al. (2006) Characterization of the Anticonvulsant, Behavioral and Pharmacokinetic Interaction Profiles of Stiripentol in Combination with Clonazepam, Ethosuximide, Phenobarbital, and Valproate Using Isobolographic Analysis. Epilepsia 47(11): 1841-1854. (Mouse, Poland)
Zangarelli A et al. (2006) Synergistic effects of caloric restriction with maintained protein intake on skeletal muscle performance in 21-month-old rats: a mitochondria-mediated pathway. The FASEB Journal 20: 2439-2450. (Rats, France)
Davies JE et al. (2005) Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice. Nat. Med., 11(6):672-7. (mice, UK)
Vacher C et al. (2005) Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease. Hum. Mol. Gen. 14(22): 34-3433. (mouse, UK)
B Ravikumar, A Acevedo-Arozena, S Imarisio, Z Berger, C Vacher, C J O'Kane, SDM Brown, DC Rubinsztein. Dynein mutations impair autophagic clearance of aggregate-prone proteins In Nature Genetics 37, 771 - 776 (01 Jul 2005)
Martínez de Lagrán M et al. (2004) Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in down syndrome motor dysfunction. Neurobiol. Dis. 15: 132-142. (mice, Spain)
Mientjes EJ et al. (2004) Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo. Hum Mol Genet. 13(13):1291-302. (mice, Netherlands)
Simon D et al. (2004) Friedreich Ataxia Mouse Models with Progressive Cerebellar and Sensory Ataxia Reveal Autophagic Neurodegeneration in Dorsal Root Ganglio. J. Neurosci. 24(8): 1987-95. (mice, France)
Buj-Bello A et al. (2002) The lipid phosphatase myotubularin is essential for skeletal muscle maintenance but not for myogenesis in mice. PNAS 99(23):15060-15065. (mice, France)
Bioseb's Grip Strength Test helps determine the maximal peak force developed by a rodent (rat or mouse) when the operator tries to pull it out of a specially designed grid or bar, which are available for both fore and hind limbs. The Grip Test has been documented in numerous literatures and allows the study of neuromuscular functions. The measurement is accomplished using a highly accurate sensor (same sensor for rat and mice) and an electronic device with a sampling rate of 1000 Hz. This ensures that the maximum force is perfectly captured and displayed, even for short and low force peaks - this is especially useful when grip testing mice.
Measurements can be displayed in grams, newtons, or lbs. The unit is directly selected on the keyboard. Data output is available through a RS232 port, a printer, or a graphic recorder. Individual measurements (up to 100) are stored in an internal memory, and can be dowloaded after the experiment.
The new Bioseb GRIP TEST Version 3+ shows numerous unique features:
• A single instrument for mice and rats, which may be used as a stand alone tool or connected to a printer or a PC
• Accessories to measure from the front paws, back paws, or the 4 paws, in a mesh grid or in a bar version (see opposite illustration)
• Easy to operate and calibrate:
1. Hold the animal by the tail or the neck's skin.
2. Move the animal down until it grasps the grid/bar.
3. Pull the animal along the sensor axle until grip is released.
Recently an embedded statistical computation has been included in the electronic device. This is a very useful feature that as been very well received and used by users of large numbers of tests. The display shows in real time the mean, standard deviation and variation coefficient from groups of animals. This feature allows also to cancel any grip strength test not correctly performed.
Specifications and main functionalities of BIOSEB Grip Test:
• NEW AND UNIQUE: internal statistical computations, a new development by Bioseb allows direct reading of the average value, standard deviation and variability for several subjects groups and up to 100 animals.
• Very fast sampling rate of 1000Hz, to secure the repeatability in the “peak” force capture and measurement
• Highly reliable sensors, 0.1% of full scale and a fine resolution (resolution is user-settable as low as 0,1g)
• Internal memory for measured data, up to 100 values can be stored manually, to be edited or downloaded later
• Data is stored in memory as a table with time/measured force
• Built-in RS 232 port allowing transfer of data to a PC or a printer
• Optional Bioseb RSIC Software allowing user to send measured values directly into a Microsoft Excel spreadsheet
Supplied with: 1 stand and counter weight, 1 grip accessory (to be chosen among the available models described above), power supply adaptor (100-240 V), user manual and tutorial.
Special model upon request: Higher capacity (marmoset), double sensor, Meyer's method (double gauge, front to front). Please enquire
THE INFORMATION IN THIS WEB SITE AND IN LINKED PAGES AND DOCUMENTS IS PROVIDED "AS IS" AND DOES NOT CREATE ANY EXPRESS OR IMPLIED WARRANTY ABOUT BIOSEB OR ITS PRODUCTS OR SERVICES.
Information published on this Web Site as well as services, product specifications, availability and prices are subject to change without notice. BIOSEB may also make improvements and/or changes in the products and/or the programs described in this Web Site at any time without notice.
BIOSEB has made reasonable efforts to verify that the information in this Web site was accurate when first published. Such information may contain errors or omissions, however, and it is subject to change without notice. Bioseb does not undertake to update this information to include any such changes or to correct errors or omissions. Bioseb assumes no responsibility for any use of the information in this Web site or for any infringement of patents or other rights of third parties that may result. Certain information may be country-specific and may not apply in all countries.
Sensor Capacity
0 - 2 kg (20N) reading 1 gram. Other capacities on request.
Accuracy
0,1 % of full scale
Resolution
0.1 g
Sampling resolution
1000 Hz
Data Output
RS232 for computer, analog output for graphic recorders
Internal memory
100 individual values
Overall dimensions
400x180x200 mm for the Single grip model and 750 x 180 x 200 mm for the Double grip model (can be used to measure fore + back limbs ).
Power supply
Power adaptor (100-240 V) or battery
Grid and Bars
Stainless steel, allowing sterilization, with a specific design to protect the animal paws from injuries, different grids and bars are available depending on the specie and the limbs to be tested.
Example dimensions of the Mouse Grid
100 x 80 mm, angled 20° (other on request).
Special models
To measure independently right and left forelimbs, To grip test small monkeys …
Show images gallery
