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The Five/nine-hole box from Bioseb is assembled with black methacrylate walls and a transparent front door. The box is equipped with an arc of 9 contiguous apertures set into the rear wall, a house light, a food pellet dispenser and a ‘pusher’ to detect the nose-pokes into the food holder. The holes not used in the experiment are blocked up using a metal insert. Each hole is equipped with photocell beams and internal LED providing visual cues specific to each hole. The intensity of the LED can be adjusted in the control unit using the digital selector. The box is placed on a stainless-steel platform and the associated tray is easily removable to clean animal excrements.
The nine-hole box is associated with the potent and versatile PackWin software in order to control the experiment (protocol configuration, experiment running) and obtain relevant data such as correct responses, incorrect responses, omissions, premature responses, perseverant responses, time out responses, total receptacle head entries, etc.
Different experimental paradigms for sustained attention, animal models of impulsive behaviour and lateralized-discrimination task can be conducted using the nine-hole box.
As an example, in the 5-choice serial reaction time task, short-lasting stimuli are given in pseudo-randomised order in one of the holes of the cage (commonly, hole 1, 3, 5, 7 or 9). If the animal nose-pokes into the correct hole, a reinforcement (pellet) is given. If the animal nose-pokes into an incorrect hole, a time-out period (no light) is given and next trial begins. The choice accuracy (% of correct responses) gives an idea of the functional integrity of the attention as well as learning processes. These parameters are mostly altered in animal models of schizophrenia and Alzheimer diseases.
2 models are available: LE-507 for mice and LE-509 for rats
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THE INFORMATION IN THIS WEB SITE AND IN LINKED PAGES AND DOCUMENTS IS PROVIDED "AS IS" AND DOES NOT CREATE ANY EXPRESS OR IMPLIED WARRANTY ABOUT BIOSEB OR ITS PRODUCTS OR SERVICES.
Information published on this Web Site as well as services, product specifications, availability and prices are subject to change without notice. BIOSEB may also make improvements and/or changes in the products and/or the programs described in this Web Site at any time without notice.
BIOSEB has made reasonable efforts to verify that the information in this Web site was accurate when first published. Such information may contain errors or omissions, however, and it is subject to change without notice. Bioseb does not undertake to update this information to include any such changes or to correct errors or omissions. Bioseb assumes no responsibility for any use of the information in this Web site or for any infringement of patents or other rights of third parties that may result. Certain information may be country-specific and may not apply in all countries.
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Parameters measured |
Number of correct responses Number of incorrect responses Number of persevering actions Number of omissions Number of anticipatory responses Number of trials performed Responses Latency Reinforcement (food, drink) intake latency Number of responses during the time-out And many user-defined parameters...
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Key features |
Entirely modular box Easily removable tray Hole leds with adjustable intensity Associated with a very complete and flexible software Personalized scientific support Up to 8 stations can be connected at once to PC through a single
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LE509 Rat Cage Dimensions |
252 (W) x 280 (D) x 240 (H) mm internal 440 x 360 x 315 mm external
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LE507 Mouse Cage Dimensions |
190 (W) x 220 (D) x 240 (H) mm internal 440 x 360 x 315 mm external
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Rat Holes Dimensions |
23mm hole diameter 14mm hole deep
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Mouse Holes Dimensions |
13mm hole diameter 10mm hole deep |
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Model:
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LE-507
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5-9 holes attention processes box
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for mouse |
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