|
 |
BEHAVIOUR |
 |
|
|
|
|

Click here to maximize
|
Aron Test or Four Plates Test
THE FOUR PLATES is an EXCLUSIVITY From BIOSEB - it is a fast tool to evaluate anxiolytic substances
- LAB OF NEUROBIO DE L'ANQUIETE ET DEPRESSION NANTES, FRANCE
- HOFFMANN-LA ROCHE Ltd BASEL
- LUNDBECK RESEARCH USAParamus, NJ, Etas Uni
- PSYCHOGENICS INC Tarrytown, Etats Unis
- Brain structures implicated in four-plate test in naïve and experienced Swiss mice using injection of diazepam & the 5-HT2A agonist DOI. By B.Petit-Demoulièrea, F.Masséa, N.Cogrela, M.Hascoët & M.Bourin. In Behav brain Res, 204(1);200-5, 2009 Dec 1.
- Anxiolytic effects of lamotrigine and JZP-4 in the elevated plus maze and in the four plate conflict test. By MM.Foremana, T.Hananiab & M.Ellera. In Eur Journ Pharmacology, 602(2-3):316-20, 2009Jan 14.
- CNS disorders-curent treatment options and the prospects for Advanced therapies. By JC.DiNunzio, Williams RO 3rd. In Drug Development and Industrial Pharmacy, 34(11):1141-67, November 2008.
- Factors triggering abolishment of benzodiazepines effects in the four-plate test-retest in mice. By B.Petit-Demoulière, M.Hascoët, M.Bourin. In European Neuropsychopharma V.18-1, p.41, January 2008.
- Anxiolytic-like effects of DOI microinjections into hoppocampus (not amygdala/PAG) in the mice. By F.Masse, B.Petit-demoulière, I.Dubbois, M.Hoscoët & al. In Behavioural Brain Research, Vol.188, p.291-297, April 2008.
- NS11394n a unique subtype-select GABAA receptor positive modulator. By NR.Mirza, JS.Larsen, C.Mathiasen, TA.Jacobsen & al. In Journal of Pharmacology and experimental Therapeutics, September 2008.
- SK3K+channel-deficient mice have enhance dopam./sero.release & altered emocional behav.. By JPR.Jacobsen, P.Weikop, HH.Hansen, JD.Mikkelsen & al. In Genes, Brain and Behavior, 2008.
- The four-plates test–retest paradigm to discriminate anxiolytic effects, In Psychopharmacology, June 2005
- EA 3256 NEUROBIOLOGIE DE L'ANXIETE ET DE LA DEPRESSION, In Psychopharmacology, June 2004
|
|
Aron 4 plates test is widely considered has an effective way to screen anxiolitics (cf LeClea'ch and all. ). However it requires a constant operator's presence. Bioseb has recently proposed a way to automatise shock counting and recording of the results, allowing to chain up to 28 Aron 4 plates cages and simply link them to a PC (RS232 com port). An elegant and economical solution to screen large numbers of mice.
Operating principle
This apparatus consists of a cage (18×25×16 cm) floored by four identical rectangular metal plates (8×11 cm) separated from one another by a
gap of 4 mm. The plates are connected to a shocker unit that can generate electric footshocks (0-3 mA; Timer 0-10 secondes; square pulses).
Following habituation period, the animal is subjected to an electric shock when crossing (transition) from one plate to another, i.e. two legs on one plate and two legs on another. Boissier et al. 1968 has described this test first.
The number of punished crossings is generaly calculated for a period of 60 s. For example an anxiolytic substance is capable of augmenting the number of punished passages.
2 publications showing the efficienty of this instrument for your research work are available for download:
Effects of benzodiazepinic and GABAergic ligands on the anxiolytic-like activity of antidepressants in the four-plate test in mice, by Hascoet, Dubois et al.
(Poster presented at the Congrès P2T Physiology, Pharmacology and Thérapeutics in Toulouse, April 2007)
Click here to send a download request for this publication
Triggering factors for the abolishment of benzodiazepines effects in the four-plate test-retest, by B. Petit-Demoulière, M. Hascoet, M. Bourin et al
(Poster presented at the Congrès P2T Physiology, Pharmacology and Thérapeutics in Toulouse, April 2007)
Click here to send a download request for this publication
|
|
|
THE INFORMATION IN THIS WEB SITE AND IN LINKED PAGES AND DOCUMENTS IS PROVIDED "AS IS" AND DOES NOT CREATE ANY EXPRESS OR IMPLIED WARRANTY ABOUT BIOSEB OR ITS PRODUCTS OR SERVICES.
Information published on this Web Site as well as services, product specifications, availability and prices are subject to change without notice. BIOSEB may also make improvements and/or changes in the products and/or the programs described in this Web Site at any time without notice.
BIOSEB has made reasonable efforts to verify that the information in this Web site was accurate when first published. Such information may contain errors or omissions, however, and it is subject to change without notice. Bioseb does not undertake to update this information to include any such changes or to correct errors or omissions. Bioseb assumes no responsibility for any use of the information in this Web site or for any infringement of patents or other rights of third parties that may result. Certain information may be country-specific and may not apply in all countries.
|
Species |
mouse
|
|
Cage materials |
white,transparent plastic and stainless steel
|
|
Dimensions |
18×25×16 cm
|
|
Shocker |
0-2 mA
|
|
Pulse |
Square
|
|
Shock delivery |
footswitch
|
|
Count |
manual or programmable counter |
|
|
Model:
|
|
|
|
Accessories :
|
|
LE 3806 MULTICOUNTER Programmable counter and SEDACOM Software |
|
|
Handbook (PDF format)
|
Instrument's tutorial
|
Instrument's FAQ
|
|
|