PRODUCT OVERVIEW
Our NIPB system provides an easy and reliable technique to measure systemic blood pressure and cardiovascular parameters in rodents without any invasive catheterisation. Given that the success of the experiment mainly relies on the animal manipulation, specifi c effort has been made in engineering a system that provides the best conditions for obtaining reliable data with a minimum number of attempts. For this purpose, the system has been designed for simplifying to the maximum the settings of the equipment as well as for minimizing animal stress during the whole procedure.
The Panlab NIBP system is also the only system in the market that proposes complete solutions for ensuring the traceability and validations of the data obtained!
KEY FEATURES
• Total reliability to realise consecutive measurements on the same animal
• Analogical Signal output for enabling cuff pressure and pulse signals registering
• Automated defl ation driven separately for each animal (minimize tail lesions)
• The same system can be used for Rat / Dog / Mice (1 transducer by specie)
• Extremely easy to use (only 1 setting button!)
• Validated for its use in anesthetized animals
• Real values provided (without any linear regression calculation)
• Easily traceable data (using a data acquisition software)
• Parameters evaluated can be visualized on-line on the digital display
HOW DOES IT WORK?
The N.I.B.P. method in animals is based on the same sphygmomanometric technique used for measuring arterial pressure in humans. Like its counterpart for human use, this kit is equipped with a cuff to occlude blood fl ow as well as a transducer to follow pulse evolution throughout the measuring process.
Systolic pressure
The cuff is infl ated until the pulse signal disappears due to the blocking of the caudal artery. Once the signal disappearance has been detected, the cuff defl ates automatically. Systolic pressure corresponds then to the pressure value on the cuff when the pulse begins to reappear.
Diastolic pressure
The cuff continues to defl ate progressively until the pulse signal recovers its initial value. The pressure reading at this moment corresponds to diastolic pressure. Our system estimates that the pulse has been completely recovered when the signal has reached 80% of the pulse baseline value (and not 80% of the systolic value)
Mean Blood Pressure (MBP)
Once the systolic and diastolic pressure values have been obtained, the system automatically calculates the mean pressure while the cuff is completely defl ated for the next evaluation. This value can be calculated using the following formula: MP = DP + 0.33 (SP - DP)
APPLICATIONS
Cardiovascular: Non-Invasive Blood Pressure, Drug screening, Phenotyping, Hypertension/hypotension studies, Obesity, Kidney disease studies, Addison’s disease studies, Sepsis, Toxin reaction studies, and much more...
PRODUCT RANGE
2 products are available:
• LE-5001: standard instrument (Data LCD display, Pressure and Pulse BNC analogical signal output, RS232/USB data port transfer to printer or SeDa-Com PC interface)
• LE-5002: similar to LE-5001, but offering permanent memory for storing up to 4000 series of data
OPTIONS
- Heating tunnels ( mono or multianimals)
- Card and software for visualising, on PC (through an USB port), the pressure and heart frequency curve. The software allows monitoring, stocking and printing of the curves.
The software is essential for experiments on mice.
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