Presentation
Weight Bearing of rodents, also named « incapacitance » test, is well known in nociceptive research studies. Traditional « static » type instruments have been used in the last years for assessing pain sensitivity.

Those static incapacitance instruments, although showing well correlated results vs paw pressure vocalization test, calibrated Von Frey filaments, etc, (cf Richebe P, Laulin JP, Simonnet G, Anesthesiology 2005, Pain 2007,...), are highly dependant on the animal (rat or mouse) positionning inside a stressfull restrainer. This makes them time consuming and difficult to use particularly when large number of rodents are considered.

Operation principle
Bioseb has now developped the Dynamic Weight Bearing Test, a new type of incapacitance test with a floor instrumented cage , allowing to measure independantly the weight bore by each limb of a free moving animal (mouse or rat). The system accuracy and resolution are insured via a metrological calibration performed prior to the data capture. During the data capture, the raw datas for each paw are synchronized with the images from a video camera and the averaged values are encrypted and recorded on a pc (via an usb link) with a sampling rate of 10 Hz, providing you with valuable data for your research on nociception/analgesia. This instrument is especially suitable for research on Parkinson and Alodynia.

Analysis and replay can be performed on site or remotely. During the analysis and replay, the operator can check and secure each limb recognition.
The weight distribution of the animal (rat or mouse), per limb, is then shown in the result window, for each time period with the mean and the variation coefficient.


Click to enlarge pictures

!New! Publication

Bioseb team presents its respectful thanks to following research teams who used the Dynamic Weight Bearing during their recent studies:

• Team of Prof. Sarret (University of Sherbrooke, Sherbrooke, Québec, Canada)
Imaging, Behavioural and Neurochemical Characteristics of a Clinically Relevant Bone Cancer Pain Model, by Louis Doré-Savard, Valérie Otis, Luc Tremblay, Karine Belleville, Mélanie Archambault et al.
(Click here to send a download request for this research poster as a PDF file)

• Team of Prof. Sarret (University of Sherbrooke, Sherbrooke, Québec, Canada)
Improving Pain Assessment In A New Mouse Model Of Bone Cancer Pain, by G. Roussy, K. Belleville, N. Beaudet and P. Sarret
(Click here to send a download request for this research poster as a PDF file)

• Team of Prof. Sarret (University of Sherbrooke, Sherbrooke, Québec, Canada)
NTS2 receptor activation as an innovative target for the treatment of neuropathic pain, by P.G. Tétreault, A. Guillemette, K. Belleville, J. Martinez, N. Beaudet and P. Sarret
(Click here to send a download request for this research poster as a PDF file)


Click on a picture to send a download request for a research poster

• Team of Dr. Ungard (McMaster University and Juravinski Cancer Centre, Hamilton, Ontario, Canada)
Examination of the mechanisms of cancer-induced bone pain in animal models, by Robert Ungard, Eric Seidlitz, Paolo De Ciantis, Vikas Sridhar, Kiran Yashpal, James L. Henry and Gurmit Singh
(Click here to send a download request for this research poster as a PDF file)

• Team of Dr. Bagi (WWCM, Global Science and Technology, Pfizer Inc., Groton)
Effect of VEGF inhibitor PF-00337210 and FAK/Pyk2 inhibitor PF-562,271 on Intra-tibial Growth of Breast Cancer Cells in Nude Rats and Mice, by Cedo M. Bagi, Rich Pero, Edwin Berryman, Daniel Aupi, Dean Wilkie and Cathy J. Andresen
(Click here to send a download request for this research poster as a PDF file)


Click on a picture to send a download request for a research poster