Bioseb's Foot Misplacement System is a unique instrument for the detailed modeling of walking and its disorders in mice and rats, with respect to motor and psychomotor skills and cognition.

Scientific Purpose

This device reveals defects in fine motor coordination during walking, making it suitable for use in functional, toxicological, and genetic models (toxicosis, alcoholism, ataxia, Parkinson's disease, etc.).

Operating principle

The equipment consists of a departure box, a corridor, and an arrival box.
The corridor is a flat ladder on which the animal can move from the starting box towards the arrival box. On both sides of the ladder, infrared sensors allow you to visualize and record the displacement of the animal as well as motor control displacement of the animal as well as motor control defects (distinguishes front and rear legs). The location and precise length of time of all the errors are recorded.
The error rate increases according to the rodent's difficulty moving and the level of difficulty of the task (traps can be created by withdrawing one or more bars).
A software makes filter sensors information, to distinguish the errors from front legs, back legs and tail.

Simplicity

The corridor is removable, which allows an easy and fast cleaning. It is adaptable, which makes it possible to test the small one or large rodent with the same apparatus: interchangeable rat/mouse corridors.

Software

Software records data collected by the sensors and calculates leg (both front and rear) and tail errors. It creates a separate results file for each animal, which is easily exportable to Excel format. The software also automatically sorts errors and directly calculates the time/report ratio of the course and error rate.


Screenshots from the foot misplacement system software