Bioseb team presents its respectful thanks to following research teams who used the Dynamic Weight Bearing (New Incapacitance Test) during their recent studies:
• Team of Prof. Doré-Savard (University of Sherbrooke, Sherbrooke, Québec, Canada) Imaging, Behavioural and Neurochemical Characteristics of a Clinically Relevant Bone Cancer Pain Model, by Louis Doré-Savard, Valérie Otis, Luc Tremblay, Karine Belleville, Mélanie Archambault et al. (Click here to send a download request for this research poster as a PDF file)
• Team of Prof. Tétreault (University of Sherbrooke, Sherbrooke, Québec, Canada) NTS2 receptor activation as an innovative target for the
treatment of neuropathic pain, by P.G. Tétreault, A. Guillemette, K. Belleville, J. Martinez, N. Beaudet and P. Sarret (Click here to send a download request for this research poster as a PDF file)
Click on a picture to send a download request for a research poster
We would like to invite those of you attending the Neuroscience 2009 meeting from September 9th to 12th to visit us: the last Neuroscience In Vivo Testing instruments will be presented there and ready to use. We are looking forward to seeing you in Warsaw!
The Bioseb Team
Activ_Meter (Actimeter for Rodents) - Publication
Bioseb team presents its respectful thanks to research teams of Prof. David (Université Paris-Sud) and Prof. Samuels (Columbia University, New York), who used the Activ_Meter (Actimeter for Rodents) during their recent studies:
Behavioral Effects of Fluoxetine in an Animal Model of Anxiety/Depression Are Mediated by Both Neurogenesis-Dependent and -Independent Mechanisms, by DJ. David, BA. Samuels, Q. Rainer, JW. Wang et al., in Neuron, 62, 2009 (Click here to download this article as a PDF file)
Abstract
Using Bioseb's Activ_Meter (Actimeter for Rodents), DJ. David, BA. Samuels, Q. Rainer, JW. Wang et al could describe a mouse model of an anxiety/depressive-like state induced by chronic corticosterone treatment, and showed that chronic antidepressant treatment reversed the behavioral dysfunctions and the inhibition of hippocampal neurogenesis induced by corticosterone treatment. Home cage activity was quantified using the ActiV-Meter (Bioseb, Vitrolles, France) over a 24 hours period. During the experiment, food and water were provided ad libitum. Various parameters such as activity time (sec), ambulatory distance (cm) and inactivity duration (calculated from the difference between immobility and motionless activity duration while the animal is eating or scratching) were recorded.
These results demonstrate the interest of Bioseb's Bioseb's ActiV_Meter (Actimeter for rodents) for monitoring activity and locomotion of rodents (mouse and rat) in the home cage.
Bioseb team presents its respectful thanks to research teams of Prof. Lazdunski (Université de Nice-Sophia Antipolis, France) and Prof. Eschalier (Clermont Université, Clermont-Ferrand, France), who used the Two-Temperatures Choice Test during their recent studies:
The mechano-activated Kþ channels TRAAK and TREK-1 control both warm and cold perception, by J. Noe, K. Zimmermann, J. Busserolles, E. Deval, A. Alloui,S. Diochot, N. Guy, M. Borsotto,P. Reeh, A. Eschalier and M. Lazdunski, EMBO Journal, 2009 (Click here to download this article as a PDF file)
Abstract
The sensation of cold or heat depends on the activation of specific nerve endings in the skin. This involves heat- and cold-sensitive excitatory transient receptor potential (TRP) channels. Using Bioseb's Two Temperaturs Choice Test, the research team could show that the mechano-gated and highly temperature-sensitive potassium channels of the TREK/TRAAK family, which normally work as silencers of the excitatory channels, are also implicated. TRAAK and TREK-1 channels control pain produced by mechanical stimulation and both heat and cold pain perception in mice. Together TREK-1 and TRAAK channels are important regulators of nociceptor activation by cold, particularly in the nociceptor population that is not activated by menthol.
These results demonstrate the interest of Bioseb's Thermal Place Preference (2 Temperatures Choice Nociception Test) to study thermal nociception, thus being a very valuable tool for your research on analgesia.
Bioseb team presents its respectful thanks to research team of Prof. Poisbeau (Institut des Neurosciences Cellulaires et Intégratives de Strasbourg), who used the Cold and Hot Plate Test during its recent studies:
Differentiating Thermal Allodynia and Hyperalgesia Using Dynamic Hot and Cold Plate in Rodents, by I. Yalcin, A. Charlet, MJ. Freund-Mercier, M. Barrot and P. Poisbeau, in The Journal of Pain, 2009 (Click here to download this article as a PDF file)
Abstract
Yalcin, Charlet, Freund-Mercier, Barrot and Poisbeau, using Bioseb's Hot and Cold Plate Test, could show that escape behavior (jumps) was the most appropriate parameter in C57Bl/6J mice, whereas nociceptive response was estimated by using the sum of paw lickings and withdrawals in Sprague-Dawley rats. They could also demonstrate that this procedure allows the detection of both thermal allodynia and hyperalgesia after peripheral pain sensitization with capsaicin in mice and in rats. In a condition of carrageenan-induced paw inflammation, they observed the previously described thermal hyperalgesia, but also revealed that rats exhibit a clear thermal allodynia to a cold or a hot stimulus.
These results demonstrate the interest of Bioseb's Dynamic Hot and Cold plate to study thermal nociception, and more particularly to study both thermal allodynia and hyperalgesia within a single paradigm in awake and freely moving rodents.
We would like to thank all of you who came to visit us on the Neurosciences 2009 in Bordeaux. You were numerous to take the opportunity for discovering the latest innovations from Bioseb, like our "Dynamic Weight Bearing System", our "Thermal Gradient Test" or our "Automated Forced Swimming Test" (Automated Porsolt Test), and for exchanging viewpoints and experience on in-vivo testing. We will inform you on this website about the next scientific congresses to which Bioseb will participate... and we are looking forward to meeting you there!
Measuring the Postural Equilibrium (weight bearing) on freely moving Mice or Rats, Bioseb's Dynamic Weight Bearing is an efficient alternative to traditional incapacitance tests for your research on analgesia/nociception.
Allowing to measure independantly the weight bore by each limb of a free moving animal, this very accurate system provides you with raw datas and computed values for each paw, which are synchronized with the images from a video camera.
Neuroscience 2008 in Washington: Bioseb on booth 629
We would like to invite those of you attending the Neuroscience 2008 meeting of the Society for Neuroscience in Washington DC on November 15 - 19 to visit us on the booth N°629. The last Neurosciences In Vivo Testing instruments will be presented there and ready to use. We are looking forward to seeing you in Washington!
ACTIV-METER: An Innovative Actimeter
Bioseb ACTIV_METER: a new actimeter for a continuous monitoring of mice and rats in their Home Cage. Innovative and performant: The Bioseb ActiV_Meter (rodent actimeter) allows to economically quantify 3 major parameters of the rodent behaviour : Movement / Motionless Activity / Immobility.
The animal remaining in its familiar environment, his position and activity can
be recorded continuously during short as well as very long actimetry experiences. Specifically developed to perform analysis in the Home Cage, Bioseb's new actimeter can be used in any other kind of environment (open field, etc...).Accuracy is guaranteed with a sampling rate of 100 Hz.
Unlike other actimetry techniques, no intervention is required on the animal (rat or mouse), and our new actimeter, Bioseb's Activ_Meter, is not disturbed by any change (like litter movements) in the cage environment.
We would like to thank all of you who came to visit us on the Measuring Behavior 2008 in Maastricht. You were numerous to take the opportunity for discovering the latest innovations from Bioseb, and for exchanging viewpoints and experience on in-vivo testing. We will inform you on this website about the next scientific congresses to which Bioseb will participate... and we are looking forward to meeting you there!
We would like to thank all of you who came to visit us on the IASP 2008 in Glasgow. You were numerous to take the opportunity for discovering the latest innovations from Bioseb, and for exchanging viewpoints and experience on in-vivo testing. We will inform you on this website about the next scientific congresses to which Bioseb will participate... and we are looking forward to meeting you there!
Cold and Hot Plate: for your research on analgesic drugs
Recent research has shown different receptors responses to "cold" and "hot" stimulations. The new Bioseb Cold and Hot Plate provides a larger range of temperatures (from 0°C to 70°C in a standard 20 to 25°C ambient ) in order to determine pain responses to either hot or cold stimuli, allowing rapid screening of narcotic analgesic drugs, or studying new responses in both mouse and rat.
Offering very fast temperature regulation (from ambient to 4°C in 10 min, and to 65°C in 5 min), the plate is accurate and stable (max. +/-0,2°C) all over the measurement range and all over the container surface, with a resolution of 0,1°C and 0,1sec. The USB interface allows data transfer of temperature, time response, date and time of the test. Very easy to use, simple to set up, the Bioseb Cold and Hot plate may soon become a standard screening tool in your lab.
We would like to thank all of you who came to visit us on the FENS 2008 in Geneva. You were numerous to take the opportunity for discovering the latest innovations from Bioseb, like our "Cold and Hot Plate" or our "Dynamic Weight Bearing System", and for exchanging viewpoints and experience on in-vivo testing. We will inform you on this website about the next scientific congresses to which Bioseb will participate... and we are looking forward to meeting you there!
Chers lecteurs,
C'est avec plaisir que nous vous présentons la newsletters Bioseb du mois de mai 2008.
Vous y découvrirez de nouvelles applications pour l'enseignement supérieur ainsi qu'un tutorial trés complet pour les travaux pratiques de physiologie humaine ayant pour thème la stimulation des muscles antagonistes chez l'homme.
Bioseb propose dans ce cadre, une suite complète d'unités d'acquisition et de capteurs avec un vaste choix de tutoriaux pour répondre aux divers besoins des cycles universitaires.Toutes vos questions et demandes spécifiques seront les bienvenues, nous y repondrons avec le plus grand intérêt.
En espérant vous compter bientôt parmis nos fidèles utilisateurs.
Sincères salutations
L'equipe Bioseb.
PS: retrouvez toutes nos nouveautés en physiologie et pharmacologie in vivo surwww.bioseb.com
Dans ce numéro:
- Stimulation of
Antagonistic Muscles
Experiment
- SI-200 Stimulus Isolator
Tech Note
- User Downloads
- Web Resources
- New LabsByDesign
Custom Physiology Labs
The iWorx newsletter is a FREE monthly publication dedicated to sharing teaching laboratory techniques and other useful information with educators in the fields of Anatomy and Physiology. We will also be sending you technical information and info on new developments at iWorx that we feel may be of use to you in your teaching and research activities.
About iWorx
iWorx has everything you need to add excitement and distance learning to any physiology teaching program. Our products include data acquisition hardware, professionally -developed physiology courseware, innovative web tools, and a full selection of transducers, cables, front ends and accessories.
While walking or running, the muscles of the lower leg work in a coordinated manner to position the foot at the proper angle during each segment of a person’s stride. As the leg is moved forward after a step has been taken, the foot moves upward in a dorsiflexion caused by the contraction of the tibialis anterior muscle on the front of the lower leg. Dorsiflexion provides the foot greater clearance from the ground as the foot is moved forward. When the foot is planted and the person’s body is being propelled forward, the foot moves downward in a plantar flexion caused by the contraction of the gastrocnemius muscle on the back of the lower leg. Plantar flexion helps push the body forward as the leg is moved backward.
In this experiment, dorsiflexion and plantar flexion will be triggered by stimulation of the muscles involved in each flexion. When stimulated, each muscle generates a compound muscle action potential, known as a M-wave, which will be recorded like an electromyogram (EMG). Each M-wave generates a muscle contraction, which causes a flexion. The range of motion of each flexion will be measured with a single-axis goniometer. The frequency of stimulation of the muscles will also be increased to demonstrate the effect of mechanical summation on the overall range of motion of the foot.
Browsing Area
Download locked Stimulation of Antagonistic Muscles experiment.
The SI-200 is a high voltage, isolated stimulator designed to deliver safe, transcutaneous stimulus pulses to a nerve or a muscle being studied. The design of the SI-200 permits the desired current of the stimulus pulse to be generated despite the impedance on the path that the current follows. The SI-200 adjusts the voltage needed to maintain that current automatically by increasing the voltage that drives the current up to a maximum of 150 volts. Because of this capability, the SI-200 is categorized as a constant current stimulator. However, the current output of the SI-200 is limited to a maximum of 20 milliamperes, with a maximum duration of 10 milliseconds and a maximum frequency of 50Hz.
SI-200 Stimulus Isolator
Learn more about the iWorx SI-200 Stimulus Isolator here, or view a Tech Note here.
Download the Updated Settings File for this Month's Experiment with LabScribe2TM Software
If iWorx users plan to use the Flexibility and Range of Motionexperiment in their course, they can obtain a copy of the settings file used to configure the LabScribe2 recording software to do this experiment by clicking here (zip file).
To learn how to create your own groups of settings files for use with LabScribe2, click here. The new Settings Manager in LabScribe2 permits numerous pieces of support material to be linked to a settings file and opened automatically when the settings file is selected from the Settings menu. In LabScribe2, animations, illustrations, movies, websites, experimental write-ups, and more can be opened automatically when a settings file is opened.
Web Resources
Find more sources of articles about gait analysis and foot movement and range of motion by going to theexternal Web resources page.
On this page we have also accumulated a host of links to informative, external physiology Web sites and conveniently categorized them into major subcategories for easy reference.
Introducing iWorx LabsByDesignTM: Design the Physiology Labs that Best Suit Your Needs.
iWorx new LabsByDesign is the easiest and most cost effective way for you to design the physiology teaching labs that perfectly fit your needs. It's a unique alternative to the one size fits all, canned approach to standard lab systems that force you to purchase equipment you don't need and will never use.
Use the Web-based LabsByDesign configurator and choose the labs you want to teach. The configurator will then tailor the necessary components from our complete line of data recording modules, sensors, electrodes, stimulators and other accessories along with the courseware necessary to support the experiments you select.
The Scisense Pressure-Volume system simultaneously measures LV pressure and volume, in small mouse hearts. The PV Loops software from Iworx allows all PV computations and graphs.
For more information about the pressure-volume systems from Scisense, or for downloading a PDF catalogue of this product range, please click here.
To download the new iWorx 2007-2008 catalogue, please see corresponding news below.
The New iWorx-Bioseb catalog 2007-2008 (english version) is available for download on Bioseb.com! A large line of full systems and components for physiological research is at your disposal, which you may also consult online on our website (click here to access the online catalog)
An exclusivity for registred users, the PDF catalog can be easily and quickly downloaded as follows:
1.Click here to access the catalog request page.. 2. If you are not registred on Bioseb website yet, please use the registration form - if you are already a registred user, please go directly to step 3.. 3. Enter the e-mail address used for your registration. 4. You will receive a download link by e-mail for the iWorx-Bioseb catalog as soon as our team will have processed your request.
BIOSEB France is pleased to announce a distribution agreement with SCISENSE INC in CANADA, who offers a complete range of pressure and pressure/volume catheters systems for intracardiac phenotyping studies in mice, rats and bigger animals.
Our customers will find a complete solution together with the powerful data acquisition systems from IWORX and its Labscribe software.
The Scisense Pressure-Volume system simultaneously measures LV pressure and volume. It is the smallest such catheter in the world and creates the least possible disruption in small mouse hearts.
Samba: measuring pressure in a beating mouse heart
A revolutionary system - the new Bioseb-Samba system is the ideal solution for all your requirements in terms of blood pressure measurement on mice, rats and bigger species.
Bioseb team presents its respectful thanks to research team of Prof. Poisbeau (Institut des Neurosciences Cellulaires et Intégratives de Strasbourg), who used its instruments during its recent studies:
Functional exploration by radiotelemetry of freely moving rats exhibiting pain symptoms following carrageenan intraplantar injection (Poster presented during the Neurosciences Congress in Montpellier, France, May 2007)
Charlet, Rajalu, Rodeau, and Poisbeau, using BIOSEB Cold+Hot Plate Test, could demonstrate that pain symptoms observed after acarrageenan injection are associated with significant locomotor impairment, postural disquilibrium and hyperthermia. They could also show that radiotelemetry of physiological/autonomic functions, used as a complement to Bioseb Cold+Hot Plate Test, was a useful technique to study pain reactions in freely moving animals.
We would like to thank all of you who came to visit us on the Neurosciences Congress 2007 in Montpellier, between the 22nd and the 25th of May 2007. You were numerous to take the opportunity for discovering the latest innovations from Bioseb, like our "2 Temperatures Choice Test" or our "ActiV_Meter", and for exchanging viewpoints and experience on in-vivo testing. We will inform you on this website about the next scientific congresses to which Bioseb will participate... and we are looking forward to meeting you there!
Bioseb team presents its respectful thanks to the following research groups,
who used its instruments during their recent studies:
Effects of benzodiazepinic and GABAergic ligands on the anxiolytic-like activity of antidepressants in the four-plate test in mice (Poster presented at the Congrès P2T Physiology, Pharmacology and Thérapeutics in Toulouse, April 2007)
This work by Hascoet, Dubois et al. presents results obtained using the ARON 4 Plates Test from Bioseb during research on anxiety by mice. They could demonstrate the clear effect of GABAergic system on citalopram, paroxetine, venlafaxine and milnaciprane mechanisms of action.
Triggering factors for the abolishment of benzodiazepines effects in the four-plate test-retest (Poster presented at the Congrès P2T Physiology, Pharmacology and Thérapeutics in Toulouse, April 2007)
The research team of B. Petit-Demoulière, M. Hascoet, M. Bourin et al could show, using the Four-Plate Test from Bioseb, a one-trial tolerance phenomenon for benzodiazepine.
A lot of researchers came to visit usduring the P2T Congress in Toulouse from the 11th till the 13th of April. This congress was an outstanding opportunity to introduce some of our new products to you, like our Thermal place preference test, our new Acti-V-Meter or the Infrared thermometer for cutaneous measurement. Thanks to all of you for visiting us!
Congress: Congress of the Brain Metabolism and Circulation S
Thanks to all numerous researchers who visited BIOSEB's stand during the Congress of the Brain Metabolism and Circulation Society on the 25th of January 2007 in Paris. These meetings are not only allowing us to show you our last innovations - they are also a pleasant occasion to define with you our new development directions, in order to offer even better instruments matching YOUR research needs. Looking forward to meeting you on our next congress - our website Bioseb.com provides up-to-date information about meeting opportunities.
The New Braintree-Bioseb 2006 catalog (english version) is available for download on Bioseb.com! A large line of general laboratory equipment is at your disposal, which you may also consult online on our website (click here to access the online catalog)
An exclusivity for registred users, the PDF catalog can be easily and quickly downloaded as follows:
1.Click here to access the catalog request page.. 2. If you are not registred on Bioseb website yet, please use the registration form - if you are already a registred user, please go directly to step 3.. 3. Enter the e-mail address used for your registration. 4. You will receive a download link by e-mail for the Braintree-Bioseb catalog 2006 as soon as our team will have processed your request.
We would like to thank all of you who came to visit us on the FENS Forum 2006 in Vienna, between the 8th and the 12th of July 2006. You were numerous to take the opportunity for discovering the latest innovations from Bioseb and Panlab, and for exchanging viewpoints and experience on in-vivo testing. We will inform you on this website about the next scientific congresses to which Bioseb will participate... and we are looking forward to meeting you there!
Nociceptive tests: Neuronal response / Signal Synchro.
For very sensitive applications, the Aesthesiometer (dynamic Von Frey) from Ugo Basile has been modified to be able to synchronise stimulation and neuronal response recording. A TTL signal can be issued, application force is settable from 0,1g up, response time is 0,2 seconds.
For applications where the force level only has to be reached but not maintained, the Bioseb Instrumented Forceps" provides the same type of TTL output if a preset force threshold is reached. The TTL allows to start the recording.
Because there is no measurement without units and you’re needing more and more units conversions for your international research projects, Bioseb offers an Online Units Converter to allow the conversion of all main units to any system of your choice:
Force: kN, daN, N, kgf, gf, lbf, pdl, dyn, kips Torque: Nm, Ncm, kgmm, lbinch Weight: t, kg, g, mg, lb, oz, c Length: km, m, cm, mm, um, in, ft, french gauge Temperature: °C, °F, °K Pressure: Pa, kPa, MPa, N/m2, N/mm2, mb, bar, mmHg, cmHg, inHg, mmH2O, cmH2O, ftH2O, psi, psf, atm Flow: m3/s, m3/min, m3/h, l/s, cfs, cfm, cfh Illuminance: lx, fc, mc, lm/cm2, lm/in2, lm/ft2, lm/m2, phot, W/m2 Luminance: alb, sb, cd/cm2, cd/in2, cd/ft2, cd/m2, lb, bl
The Units converter is available from any webpage on our site by clicking on the link in the main menu.
You do not find the unit you are looking for? Send us an e-Mail and we’ll immediately add it to our converter for you.
All its electronics for Von Frey and grip test. Together with a large backlighted screen the units comes with a statistic menu that calculates average and standard deviation on settables trials.