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SEPTEMBER 2017 - CONTENTS:

Special Issue - European Orthopedic Research Society (EORS) Meeting 2017 - Munich
- Difficulties of analyzing motor-function in general, and gait deficit in particular: Bioseb's expertise
- 25th Annual and Anniversary Meeting of the European Orthopaedic Research Society (EORS): held 13-15 September 2017 in Munich, Germany - Meet Bioseb on booth #6

In terms of rodent gain measurement, how can we help you?
- Kinetic Weight Bearing (KWB): able to characterize natural gait parameters of freely walking rodents
- New Automated Ladder Test: a standard task where the rat/mouse is expected to cross a corridor, placing its paw on each ladder's rod

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JUNE 2017 - CONTENTS:

Special Issue - Mediterranean Neuroscience Society 2017 - Malta
- Do you have the right tool for your Neuroscience Research?
- Bioseb at the 6th Conference of MNS in Malta, June 12-15th, 2017

Perfect devices for pre-clinical studies
- PARKINSON / Grip Strength Test: An easy way to objectively quantify the muscular strength of rodents: ideal for studying myopathy & neurodegenerative diseases
- NEURODEGENERATIVE DISEASES & ALZHEIMER / Novel Object Recognition - 3D: An innovative setup for the automation of the Novel Object Recognition Test, based on 3D-camera based technology
- COGNITIVE DISORDERS & NEUROSURGERY / Stereotaxic frames: Electronic set-up and compact LCD: ideal for Neurosurgery and experiments on the Spinal Cord!

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APRIL 2017 - CONTENTS:

Special issue: 2017 Osteoarthritis Research Society International World Congress in Las Vegas
- Bioseb present on booth 6 for demonstration of ground-breaking instruments

Measuring devices for pain and weight bearing evaluation:
- Advanced Dynamic Weight Bearing Instrument: now available for guinea pigs! Ideal for your work on Joint destabilization.
- Electronic Von Frey instrument with embedbed camera! A new tool for limb withdrawal threashold, useful after meniscus surgery
- KWB: "New tool to assess walking patterns in the development of OA pain : Kinetic Weight Bearing", presented by K. Starowicz

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JANUARY 2017 - CONTENTS:

Happy new year 2017!
- Looking forward to a new year on your side, helping you by developing the tools you need for your ground-breaking research work!

Highlights of 2016:
- NORT3D: A brand new innovative setup for the automation of the Novel Object Recognition Test: set up our software in 3 clicks!
- EVF5: A quick and easy solution to determine the mechanical sensitivity threshold in rodents - now with embedded video!
- ACTIVWHEELS: High-res instrumented wheel with digital display or software to record 20 different variables pertaining to voluntary exercise

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NOVEMBER 2016 - CONTENTS:

Special Issue - SfN Meeting 2016 in San Diego
- Bioseb is attending the 46th annual Society for Neuroscience conference in San Diego

Demonstration of Bioseb's innovative instruments:
- Activity Meter and Wheel - Extended monitoring of spontaneous activity of rodents in home cage environment
- Kinetic Weight Bearing - Automated analysis of gait and weight distribution during spontaneous locomotion
- Advanced Dynamic Weight Bearing - Accurate and efficient video based incapacitance test in freely moving rodents
- NEW! Electronic Von Frey 5 - Powerful and still user friendly electronic device to determine mechanical sensitivity threshold in one trial. Now with embedded video!
- 3D Novel Object Recognition - Innovative design to automatically track exploration patterns with 3D camera for more discriminative analysis
- Two Temperature and Thermal Gradient Choice Test - Operator independent instrument to study thermal pain thresholds and temperature preference

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JUNE 2016 - CONTENTS:

Special Issue - FENS Meeting 2016 in Copenhagen
- Visit us at the FENS Meeting in Copenhagen, July 2nd - 6th, at booth #129

Novel Object Test
- Real-time scoring based on user-defined criteria
- Video Tracking with replay mode

Forced Swimming Test
- Monitor 4 animals simultaneously
- Automatic detection of 3-behavior states: climbing, swimming, floating

Gait analysis test
- Gait & Force assessment in one unique device !
- Automatic run detection and scoring

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MARCH 2016 - CONTENTS:

Special Issue - OARSI Meeting in Amsterdam
- OsteoArthritis Research Society International (OARSI) World Congress in Amsterdam, Netherland from 31st of March to 3rd of April

Evoked pain
- Electronic Von Frey: For sensibility threshold of rodent's plantar area
- Smalgo: With its specific stimulator for joint-application, extremely useful in OA-research
- Rodent Pincher: For the mechanical threshold in limbs and tail

Spontaneous pain
- Static Weight Bearing (SWB) is a simple device, and allows a basic measure of instability in the hind paws
- Dynamic Weight Bearing (DWB) allows pain assessment on all 4 paws, during a non-restrained exploration of the cage
- Kinetic Weight Bearing (KWB) give the results of the gait efforts applied by a rat or a mice, during a walking sequence

Pain-related behavior
- Activity monitoring for 24hr or more, with its Activmeter, an innovative way to quantify rodent's activity in its home-cage
- Spontaneous exercise observation, thanks to Running Wheels equipped with counter and software

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OCTOBER 2015 - CONTENTS:

Special Issue - How To Get Your Work Published
- 1. Use An Operator-independent Assay For Objective Data Collection
- 2. Use State-of-the-art Technology
- 3. Stand On The Shoulders Of Giants
- 4. Meet Us In Chicago And Discover How We Can Help You

Sfn Meeting 2015
- Meet Bioseb In Chicago On Booth 2055

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SEPTEMBER 2015 - CONTENTS:

Special Issue - Tip of the Month - Kinetic Weigt Bearing (KWB)
- Dual technology: video + sensors that yield information curves on the distribution of force over time for each paw
- Automated recognition of valid runs: saves valuable lab man hours and makes data acquisition more consistent
- Ground-breaking: Allows new research - phenotyping of CNS disorders such as stroke, neurodegenerative diseases, spinal cord injuries, trauma models (nerve crush, SNI, etc.)

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SEPTEMBER 2015 - CONTENTS:

QTK: Automated QUIETEK CO2 induction system s
- Follow ethical rules largely admitted by the scientific community (2013 AVMA guidelines)
- Manages different levels of concentration and thus to switch from unconsciousness to death in repeatable manner
- Reduces stress and pain experienced by the animal but also ensures the safety of the staff responsible for the procedure

RAPID-ID: Ear tags with QR Codes Millions of IDs
- A proprietary combination of alphanumeric digits providing millions of unique identification numbers
- Available in 5 colors
- Compatible with most available industry scanners

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AUGUST 2015 - CONTENTS:

TIP OF THE MONTH - DYNAMIC WEIGHT BEARING TEST
- Faster and more accurate paw identification: an efficient and advanced alternative to traditional incapacitance or static weight bearing test
- No over-stressing of the amimal: it is allowed to move freely and without restraint in the chamber
- Speed of operation and operator independence factor owing to the cutting-edge video and computer tracking software

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JUNE 2015 - CONTENTS:

TIP OF THE MONTH - AUTOMATED FORCED SWIMMING TEST
- TYC (Teach Your Computer) algorithm: train the software to use custom scored parameters
- Comparison of scoring protocols: eliminates time-consuming training for students and provides consistency across multiple studies
- Improve speed and accuracy: Bioseb's Forced Swim Test and software module are the premiere products in their class on the market today

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MAY 2015 - CONTENTS:

NEUPSIG and SfN Meetings 2015 in Nice and Monptellier: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2014 and 2015

Kinetic Weight Bearing: Automated analyzis of gait parameters
- Automatically analyze the weight borne on each paw.
- Unique technology: the floor is made of 3 sensor-mats that directly provide the true peak force in grams.
- Complementary synchronized gait parameters are also computed.

Activity Wheels: Anxiety-like and sex-dependent behaviors
- Provides information regarding troubles of circadian rhythms.
- Study the effect of voluntary exercise on anxiety-related behavior.
- Ideal for long-term studies and the acquisition can be paused or started anytime.

Dynamic Weight bearing: New applications
- A powerful and non-invasive method to phenotype variety of models.
- Our customer have now focused on PELVIC/ABDOMINAL pain with potential applications such as endometriosis diseases.

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NOVEMBER 2014 - CONTENTS:

SFN Meeting 2014 in Washington, DC: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2014

Novel Object Recognition Test: 3D sensor improves the test further!
- Adds discriminating parameters to the object exploration of rodents within an Open field test.
- Muzzle position, body orientation, time spent can now be combined with sniffing or rearing behaviors
- For studies on memory of objects and the associated brain structures and systems

Electronic Von Frey: now with embedded video!
- A quick and easy solution to determine the mechanical sensitivity threshold in rodents
- A new, integrated camera allows you to aim at the force application spot by looking at the screen
- Making the Electronic Von Frey even more convenient to use: more precise movement and better control!

Thermal Place Preference Version 2: Fully automatic!
- Ready for the next generation of computers and tablets and is much easier to use
- New algorithm for tracking activity and detecting zone transitions
- New improved electronics are more stable and result in faster temperature transitions

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OCTOBER 2014 - CONTENTS:

IASP Meeting 2014 in Buenos Aires: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2014

Activity wheel:A new innovative model for measuring non-reflexive pain
- 1 LCD display per wheel showing CW and CCW distances
- Fully compatible with chronobiology software
- Monitor up to 64 wheels linked on a bench or on a rack

Electronic Von Frey: now with embedded video!
- A quick and easy solution to determine the mechanical sensitivity threshold in rodents
- A new, integrated camera allows you to aim at the force application spot by looking at the screen
- Making the Electronic Von Frey even more convenient to use: more precise movement and better control!

Thermal Place Preference Version 2: Fully automatic!
- Ready for the next generation of computers and tablets and is much easier to use
- New algorithm for tracking activity and detecting zone transitions
- New improved electronics are more stable and result in faster temperature transitions

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July 2014 - CONTENTS:

FENS Meeting 2014 in Milan: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2014

Novel Object Recognition Test: Exclusive new 3D technology
- Adds discriminating parameters to the object exploration of rodents within an Open field test.
- Muzzle position, body orientation, time spent can now be combined with sniffing or rearing behaviors
- For studies on memory of objects and the associated brain structures and systems

Electronic Von Frey: now with embedded video!
- A quick and easy solution to determine the mechanical sensitivity threshold in rodents
- A new, integrated camera allows you to aim at the force application spot by looking at the screen
- Making the Electronic Von Frey even more convenient to use: more precise movement and better control!

Thermal Place Preference Version 2: Fully automatic!
- Ready for the next generation of computers and tablets and is much easier to use
- New algorithm for tracking activity and detecting zone transitions
- New improved electronics are more stable and result in faster temperature transitions

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April 2014 - CONTENTS:

American Pain Society (APS) Meeting 2014 in Tampa: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2013 and 2014

Dynamic Weight Bearing: phenotyping & pain severity in rodents
- The latest innovation from BIOSEB R&D team to evaluate non-evoked pain severity scale
- A clear correlation of pain level and weight bearing allows accurate pain assessment
- A useful pain severity scale that sensitively differentiates between various pain models

Thermal Place Preference: an exclusive automatic solution by Bioseb
- Allows researchers to work on unrestrained animals (mice and rats)
- Providing pure, objective data using a camera
- Operator-independent and highly accurate thanks to powerful new software!

Last minute: Camera-based electronic Von Frey prototype!
- A quick and easy solution to determine the mechanical sensitivity threshold in rodents
- A new, integrated camera allows you to aim at the force application spot by looking at the screen
- Making the Electronic Von Frey even more convenient to use!

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NOVEMBER 2013 - CONTENTS:

Society for Neuroscience Meeting 2013 in San Diego: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2013

Open Field: New 3D sensor to detect rearing & sniffing during exploration!
- 100% detection of allrearing, even the very short ones, thanks to exclusive sensor!
- No more extrapolation from the tracking detection - only true height measurement!
- Only three clicks arenecessary to run a test.

FST: Dual Sensor expertise for the automation of the Porsolt test in rats!
- An original setup that automatically detects 3 states during Porsolt's test
- States detected: Resting/Floating,Swimming, and Climbing/Struggling
- Teach the softwarehow to automatically differentiate the different states

KWB : Measures propulsive forces using gait analysis system
- A unique and very easy-to-use technology.
- Now available as a release version, featuring up to 6000 pressure sensors
- A powerful tool to evaluate models on spinal cord injuries
- Also useful for arthritis by Hemisection orinjection, brain trauma, neurodegenerative models and motor deficiencies

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MAY 2013 - CONTENTS:

Canadian Neuroscience Meeting 2013 in Toronto: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2012 and 2013

Forced Swimming: Reinvention of the Automated Dualsens Porsolt Test for rats!
- Physically measured, tracked and recorded are both the vibrations caused by a swimming animal as well as the video record of that same animal swimming or climbing.
- Multiple animals can be tested in batches of four for very high throughput!

KWB: Kinetic Weight Bearing Instrument
- A major breakthrough in the evaluation of weight distribution during a spontaneous walking session
- Kinetic analysis of the weight applied by each paw/ comparison between steps

Jump Test: Dynamic Cold/Hot Plate Test
- An entirely new set-up for the evaluation of escape behavior of mice experiencing a rise in temperature on an aluminum plate upon which the mice are in motion.
- Detect the jumps of the mouse within its cage and in total darkness!

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OCTOBER 2012 - CONTENTS:

Society for Neuroscience meeting 2012 in New Orleans: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2012

KWB: Kinetic Weight Bearing Instrument
- A major breakthrough in the evaluation of weight distribution during a spontaneous walking session
- Kinetic analysis of the weight applied by each paw/ comparison between steps

EPM3C: New '3­CLICKS' software for the elevated + maze and zero maze
- The new EPM­3C software from BIOSEB features unprecedented simplicity to run ELEVATED + MAZE or ZERO MAZE protocols
- User interface includes pre­defined zones with easy­-to-­adjust reporting of in/out times, speed of motion, time spent in each arms (open/closed), automatically !

Dynamic Weight Bearing: Non-evoked pain studies to avoid overdosing?
- New publication: Comparison of evoked and non­evoked endpoints in a rodent pain model and potential relevance to non­ evoked human pain, by Dr. Dominick Li, Eli Lilly

Automated Foot Misplacement: A unique tool to assess psychomotor skills
- A unique instrument on the market for the detailed modeling of walking and its disorders in mice and/or rats, with respect to motor and psychomotor skills and cognition.
- NOW available! Parallel digital video recording tool to enrich results and separate the left and right side.

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AUGUST 2012 - CONTENTS:

IASP Meeting 2012 in Milan: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2012

Thermal nociception: Bioseb's flexible range of cold/hot instruments
- 1. The Cold/Hot Plate, which is opening new investigation fields for your research on analgesia and nociception.
- 2. By combining 2 Cold/Hot plates in our Thermal Place Preference Test, you have the possibility to assess temperature preference by determining the preferred temperature of the animal
- 3. By adding a special designed corridor between the two plates you can demonstrate thermal place preference and assess temperature comfort threshold on rodents (mouse and rat) in a fully operator­-independent manner on freely moving rodents.

KWB: Kinetic Weight Bearing Instrument
- A major breakthrough in the evaluation of weight distribution during a spontaneous walking session
- Kinetic analysis of the weight applied by each paw/ comparison between steps

Other instruments: more innovation from Bioseb presented at FENS meeting 2012
- Automatic Forced Swimming Test, Rodent Pincher, Dynamic Weight Bearing, Fully automatic Tail Suspension Test...
- Come and visit Bioseb on FENS meeting 2012 to get a demonstration!

Last minute: new scientific posters mentioning Bioseb's instruments
- Bioseb team presents its respectful thanks to all research teams who used our In­Vivo research instruments during their recent studies, and mentioned our systems in numerous posters.

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JULY 2012 - CONTENTS:

FENS Meeting 2012: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2012


KWB: Kinetic Weight Bearing Instrument
- A major breakthrough in the evaluation of weight distribution during a spontaneous walking session
- Kinetic analysis of the weight applied by each paw/ comparison between steps

Other instruments: more innovation from Bioseb presented at FENS meeting 2012
- Automatic Forced Swimming Test, Rodent Pincher, Dynamic Weight Bearing, Fully automatic Tail Suspension Test...
- Come and visit Bioseb on FENS meeting 2012 to get a demonstration!

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JUNE 2012 - CONTENTS:

Activity wheels:
- A new innovative model for measuring non-evoked pain !
- New publication in Boston Children?s Hospital: highlights the use of Bioseb's wheel as a non-reflexive measure of pain levels

Dynamic Weight Bearing : New automated upgrade available !
- New development: save valuable time in evaluating the weight borne by each individual paw of a rodent subject.
- Ask Bioseb to upgrade your Dynamic Weight Bearing System

Grip Strength Test in ALS Research
- New publication by Garbuzova-Davis of the University of South Florida.
- Grip Test can be used as quantitative measure to demonstrate the progression of the disease.

Bioseb.com: Software Versions and Updates
- Find information about our software, including the latest version available and the OS compatibility.
- Interact with our R&D team: get information, updates and support.

Upcoming meetings: meet Bioseb's team on following congresses
- FENS Barcelona - July 14-18, 2012 - Centre Convencions Internacional Barcelona (CCIB) - Spain
- IASP Milan - August 27-31, 2012 - Milano Convention Centre - Italy
- SFN New Orleans - October 13-17 - Ernest N. Morial Convention Center - USA

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NOVEMBER 2011 - CONTENTS:

Scientific Congress
- Neuroscience meeting 2011: our latest instruments in Washington

New developments:
1. DWB-Video: The new automated version of our popular Dynamic Weight Bearing Systems
2. Smalgo-GT: A modified version of our SMall animal ALGOmeter, for big animals (cats, dogs, pigs, horses?)
3. Operand Escaping Test: unique set of cages for our Thermal Place Preference Test, to explore pain modulation mechanisms
4. Thermal Place Preference Test: New design : a single casing for both plates, with independant and advanced temperature control

Anxiety & Depression
- FST X'PERT: track combined sensor based Forced Swimming Test for Mice
- Tail Suspension Test: high-throughput systen, up to 6 mice, entirely automated

Nociception & Analgesia
- Algometer family: for rodents and bigger animals, mechanical pain threshold for OA models, low back pain, tendon related pain etc.
- Cold + Hot Plate: large range of temperatures (?3 to +65°C), can ramp to a defined temperature and run in temperature cycles
- Coming soon: video based software to count jumps distribution over time, please visit us to be the first to test !
- Gradient Thermal Test: automated instrument offering a 1,25m long thermal gradient to assess temperature of comfort.

Activity & Behavior
- Activmeter: dedicated to home cage activity evaluation, especially designed for long term experiments.

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MAY 2011 - CONTENTS:

Scientific Congress
- Canadian Neuroscience Meeting 2011 in Quebec City from May 29th to June 1st

Anxiety & Depression
- Automated Force Swimming Test: combining a vibratory signal with a synchronized video, with Expert scoring feature.
- Automated Tail Suspension Test: load cell based system, records and quantifies Immobility time, Energy value and Power in motion.

Nociception & Analgesia
- Dynamic Weight Bearing: measures the weight bearing over the four paws of a freely moving animal.
- Small Animal Algometer: developed to be used in models of low back pain and joint pain related to OA, can get a pain threshold on any region of the animal.
- Two Temperatures Choice Test: operator-independent test, automatic recording by video tracking system.
- Gradient Thermal Test: automated instrument offering a 1,25m long thermal gradient to assess temperature of comfort.

Activity & Locomotion
- Activmeter: dedicated to home cage activity evaluation, especially designed for long term experiments.
- Grip Strength Meter : a well known and referenced instrument that can be used both in rats and mice .

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JULY 2010 - CONTENTS:

Scientific Congress
- 7th Forum of European Neurosciences (FENS) is opening in Amsterdam

Anxiety & Depression
- Automated Force Swimming Test in mice: our sensor-based FST has a unique Expert comparative scoring analysis option.

Nociception & Analgesia
- Bioseb's SMALGO (SMall animal ALGOmeter) fits on your finger and allows to apply a force or pressure on the desired location
- Dynamical Weight Bearing Test: allowing to measure independantly the weight bore by each limb of a free moving rodent

Thermal stimulation
- Thermal Place Preference: the new ?2 Temperature Choice Test?, totally operator independant
- Cold + Hot Plate: large range of temperatures (?3 to +65°C), can ramp to a defined temperature and run in temperature cycles
- Gradient Thermal Test: an automated instrument offering a temperature gradient to assess thermal place preference and comfort threshold.

Activity & Behaviour:
- Activmeter: New instrument from our R&D, allows continuous monitoring of the activity and movements of mice or rats in their ?home cage?

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MARCH 2010 - CONTENTS:

Pain & Nociception
- Dynamic Weight Bearing (DWB) - Coming soon: automatic paw position detection
- Rodent pincher: new design available! New branches and a more heavy body for a more stable handling.

Promotional offer
- Free home cage for our ActivMeter !

Scientific congresses and meetings
- IASP Montreal 29 August- 02 september 2010
- FENS Amsterdam July 03-07 2010
- SFN 2010 November 13-17 2010

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Bioseb - In Vivo Research Instruments
Phone worldwide : +33 442 344 360 - USA/Canada : (727) 521-1808
e-Mail : Worldwide: info@bioseb.com - USA/Canada: sales@eb-instruments.com