INSTITUT DE RECHERCHE SERVIER Croissy sur Seine, France
INSERM Paris, Creteil, France
HOWARD FLOREY INSTITUTE Melbourne, Australia
NOVARTIS Basel, Switzerland
ROCHE Basel, Switzerland
GLAXO SMITH KLINE UK
HELMHOLTZ ZENTRUM MÜNCHEN Neuherberg, Germany
GEDEON RICHTER Budapest, Hungaria
CENTER OF MENTAL HEALTH Mannheim,Germany
UNIVERSITY OF NANTES Nantes, France
CNRS Valbonne, Bordeaux, Rouen, France
SANOFY AVENTIS Bagneux, France
Swiss Federal Institute of Technology Lausanne, Suisse
UNIVERSITE PARIS SUD Chatenay Malabry, France
INSTITUTE OF EXPERIMENTAL MEDICINE Budapest, Hongrie
HELMHOLTZ ZENTRUM MÜNCHEN Neuherberg, Allemagne
SERVIER Croissy sur seine, France
INRA Bordeaux, France
IPSEN INNOVATION Les Ulis, France
LILLY TAIWAN
Subchronic Alpha-Linolenic Acid Treatment Enhances Brain Plasticity and Exerts an Antidepressant Effect: A Versatile Potential Therapy for Stroke. By Blondeau N et al. In Neuropsychopharmacol., 2009.
) CNS Disorders—Current Treatment Options and the Prospects for Advanced Therapies. By DiNunzio JC et al. In Drug Development and Industrial Pharmacy 13:1-27, 2008.
Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease. By MJ.Dowiea, HB.Bradshawb, ML Howardc, LFB.Nicholsond & al. In The Journal of Neuroscience456-6. 2009 Jun 10.
Behavioural and neuroplastic effects of the new-generation antidepressant agomelatine compared to fluoxetine in glucocorticoid receptor-impaired mice. By E.Païzanisa, T.Renoira, V.Lelievrea, F.Saurinia & al. In Neuropharmacology 1-16. 2009 Sept.
Altered serotonin receptor expression associated with depression related behav. in R6/1 transgen. mouse mod. of Huntington disease. By TYC Pang, X.Du, MS.Howard & AJ.Hannan. In Human molecular genetics 753-66. 2008 Nov 13.
Differential long-term effects of MDMA on serontoninergic syst. & hippoc. cell prolif. in 5HTT knock-out vs. wild-type mice. By T.Renoir, E.Pazanis, ME.Yaccoubi, FA.Saurini & al. In International Journal of Neuropharmacology, Cambridge University, July 2008.
Lasting depression Syndrome Prod. by reduct in Serotonin Uptake in postnat. dev. : Evidence from sleep, stress & behav.. By D.Popa, C.Lena, C.Alexandre, J.Adrien. In The Joural of Neuroscience 28(14):3546-3554, April 2008.
UNIT 5.8 Rodent Models of Depression: Forced Swim and Tail Suspension Behavioral Despair Tests in Rats and Mice. By Castagné V et al. In Current Protocols in Pharmacology., 38:5.8.1-5.8.11, 2007.
Calcineurin (protein phosphatase 2B) is involved in the mechanisms of action of antidepressants. By Crozatier C et al. In Neuroscience , 144(4):1470-1476, 2007.
Suitability of tamoxifen-induced mutagenesis for behavioral phenotyping. By Vogt MA et al. In Experimental Neurology, 211(1):25-33, 2007.
Early Life Blockade of 5-Hydroxytryptamine 1A Receptors Normalizes Sleep and Depression-Like Behavior in Adult Knock-Out Mice Lacking the Serotonin Transporter. By Alexandre C et al. In J. Neurosci., 26(20): 5554-5564, 2006.
IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors. By Chourbaji S et al. In Neurobiology of Disease ,23(3):587-594, 2006.
Estrous cycle effects on behavior of C57BL/6J and BALB/cByJ female mice: implications for phenotyping strategies. By Meziane H et al. In Genes, Brain and Behavior, 6(2):192-200, 2006.
Fluoxetine effects in a new transgenic model of depression By E.Païsanis, L.Lanfumey & al. In Posters (French) P2T Pharmacology and Physiology Association meeting, April 2006
The Tail Suspension Test As A Model For Assessing Antidepressant Activity: Review Of Pharmacological And Genetic Studies In Mice. By Cryan, Mombereau and Vassout. In Neuroscience & Biobehavioral Reviews ;29(4-5):571-625 (2005)
Stress-Induced Anhedonia in Mice is Associated with Deficits in Forced Swimming. By Strekalova, Spanagel & al. In Neuropsychopharmacology (2004) 29
Genetic and Pharmacological Evidence of a Role for GABAB Receptors in the Modulation of Anxiety- and Antidepressant-Like Behavior By Mombereau & al. In Neuropsychopharmacology (2004) 29
Dieser Test erlaubt die Auswertung der psychotropischen Wirkung von Medikamenten (Antidepressiver, Sedativer...). Es ist eine einfache, schnelle (max. 6 Minuten) und schmerzlose Methode.
Gemessen wird die Aktivität einer am Schwanz aufgehangenen Maus, die Ihrer Situation entkommen will. Während dem Test werden die Bewegungen der Maus aufgenommen und die Kraft und die Leistung berechnet.
Dieser Test von BIOSEB ist völlig automatisiert. Das komplette System besteht aus der Aufhängevorrichtung (3 Mäuse pro Vorrichtung) und der Software zur Steuerung, Aufnahme, und Analyse des Experimentes.
Die Software läuft unter Windows XP und zeigt 3 Parameter an: Immobilitätszeit, Energie und Leistung.
Die Ergebnisse werden anschliessend mit Tabellen und Balkendiagrammen dargestellt. Die Daten können zusätzlich in andere Softwares wie MS-Excel zur weiteren Analyse übertragen werden.
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