INSTITUT DE RECHERCHE SERVIER Croissy sur Seine, France
INSERM Paris, Creteil, France
HOWARD FLOREY INSTITUTE Melbourne, Australia
NOVARTIS Basel, Switzerland
ROCHE Basel, Switzerland
GLAXO SMITH KLINE UK
HELMHOLTZ ZENTRUM MÜNCHEN Neuherberg, Germany
GEDEON RICHTER Budapest, Hungaria
CENTER OF MENTAL HEALTH Mannheim,Germany
UNIVERSITY OF NANTES Nantes, France
CNRS Valbonne, Bordeaux, Rouen, France
SANOFY AVENTIS Bagneux, France
Swiss Federal Institute of Technology Lausanne, Suisse
UNIVERSITE PARIS SUD Chatenay Malabry, France
INSTITUTE OF EXPERIMENTAL MEDICINE Budapest, Hongrie
HELMHOLTZ ZENTRUM MÜNCHEN Neuherberg, Allemagne
SERVIER Croissy sur seine, France
INRA Bordeaux, France
IPSEN INNOVATION Les Ulis, France
LILLY TAIWAN
• Cheng P.-H., Li C.-H., Her L.-S., Chang Y.-F., Chan A., Chen C.-M. et al. (2012) Significantly differential diffusion of neuropathological aggregates in the brain of transgenic mice carrying N-terminal mutant huntingtin fused with green fluorescent protein. Brain Struct Funct. [Epub ahead of print]. (Taiwan)
• Farley S., Dumas S., El Mestikawy S., Giros B. (2012) Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: Effects of fluoxetine and MK-801. Neuropharmacology, 62(1):503–517. (France)
• Schulte-Herbrüggen O., Vogt M., Hörtnagl H., Gass P., Hellweg R. (2012) Pramipexole is active in depression tests and modulates monoaminergic transmission, but not brain levels of BDNF in mice. European Journal of Pharmacology, 677(1–3):77–86. (Germany)
• Fournet V., Schweitzer A., Chevarin C., Deloulme J.-C., Hamon M., Giros B. (2012) The deletion of STOP/MAP6 protein in mice triggers highly altered mood and impaired cognitive performances. Journal of Neurochemistry, 121(1):99–114. (France)
• Berger S., Weber T., Perreau-Lenz S., Vogt M., Gartside S., Maser-Gluth C.et al. (2012) A Functional Tph2 C1473G Polymorphism Causes an Anxiety Phenotype via Compensatory Changes in the Serotonergic System. Neuropsychopharmacology. [Epub ahead of print]. (Germany)
• Narboux-Nême N., Sagné C., Doly S., Diaz S., Martin C., Angenard G. et al. (2011) Severe Serotonin Depletion after Conditional Deletion of the Vesicular Monoamine Transporter 2 Gene in Serotonin Neurons: Neural and Behavioral Consequences. Neuropsychopharmacology, 36:2538-2550. (France)
• Kim S.-J., Lee H., Joung H.-Y., Lee G., Lee H.-J., Shin M.-K. et al. (2011) T-bet deficient mice exhibit resistance to stress-induced development of depression-like behaviors. Journal of Neuroimmunology, 240–241(15):45–51. (Republic of Korea)
• Farley S., Apazoglou K., Witkin J., Giros B. Tzavara E.T. (2010) Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm. The International Journal of Neuropsychopharmacology, 13:1207-1218. (France)
• Païzanis E., Renoir T., Lelievre V., Saurini F., Melfort M., Gabriel C. et al. (2010) Behavioural and neuroplastic effects of the new-generation antidepressant agomelatine compared to fluoxetine in glucocorticoid receptor-impaired mice. Int J Neuropsychopharmacol., 13(6):759-74. (France)
• Kwon S., Lee B., Kim M., Lee H., Park H.-J., Hahm D.-H. (2010) Antidepressant-like effect of the methanolic extract from Bupleurum falcatum in the tail suspension test. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 34(2):265–270. (Republic of Korea)
• Fournet V., Jany M., Fabre V., Chali F., Orsal D., Schweitzer A. et al. (2010) The deletion of the microtubule-associated STOP protein affects the serotonergic mouse brain network. Journal of Neurochemistry, 115(6):1579–1594. (France)
• Castagné V., Moser P., Roux S., Porsolt R.D. (2010) Rodent models of depression: forced swim and tail suspension behavioral despair tests in rats and mice. Curr Protoc Pharmacol. , Chapter 5:Unit 5.8. (France)
• Dowie MJ., Bradshaw HB., Howard ML., Nicholson LFB. & al. (2009)Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease. Neuroscience,163(1):456-65. (New Zealand)
• Blondeau N et al. (2009)Subchronic Alpha-Linolenic Acid Treatment Enhances Brain Plasticity and Exerts an Antidepressant Effect: A Versatile Potential Therapy for Stroke. Neuropsychopharmacol.,34(12):2548-59. (France)
• DiNunzio JC et al. (2008) CNS Disorders—Current Treatment Options and the Prospects for Advanced Therapies. Drug Dev Ind Pharm.,34(11):1141-67. (USA)
• Pang T.Y., Du X., Zajac M.S., Howard M.L., Hannan A.J. (2008)Altered serotonin receptor expression is associated with depression-related behavior in the R6/1 transgenic mouse model of Huntington's disease. Hum Mol Genet., 18(4):753-66. (Australia)
• Renoir T., Pazanis E., Yaccoubi M.E., Saurini FA. & al. (2008) Differential long-term effects of MDMA on the serotoninergic system and hippocampal cell proliferation in 5-HTT knock-out vs. wild-type mice. Int J Neuropsychopharmacol., 11(8):1149-62. (France)
• Popa D., Léna C., Alexandre C., Adrien J. (2008) Lasting syndrome of depression produced by reduction in serotonin uptake during postnatal development: evidence from sleep, stress, and behavior. J Neurosci., 28(14):3546-54. (France)
• Crozatier C., Farley S., Mansuy I.M., Dumas S., Giros B., Tzavara E.T. (2007) Calcineurin (protein phosphatase 2B) is involved in the mechanisms of action of antidepressants. Neuroscience, 144(4):1470-1476. (France)
• Vogt M.A., Chourbaji S., Brandwein C., Dormann C., Sprengel R., Gass P. (2007)Suitability of tamoxifen-induced mutagenesis for behavioral phenotyping. Experimental Neurology, 211(1):25-33. (Germany)
• Alexandre C., Popa D., Fabre V., Bouali S., Venault P., Lesch K.P. et al. (2006) Early Life Blockade of 5-Hydroxytryptamine 1A Receptors Normalizes Sleep and Depression-Like Behavior in Adult Knock-Out Mice Lacking the Serotonin Transporter. J. Neurosci., 26(20): 5554-5564. (France)
• Chourbaji S., Urani A., Inta I., Sanchis-Segura C., Brandwein C., Zink M. et al. (2006)IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors. Neurobiology of Disease, 23(3):587-594. (Germany)
• Meziane H., Ouagazzal A.M., Aubert L., Wietrzych M., Krezel W. (2006) Estrous cycle effects on behavior of C57BL/6J and BALB/cByJ female mice: implications for phenotyping strategies. Genes, Brain and Behavior, 6(2):192-200. (France)
• Païsanis E., Lanfumey L. et al. (2006) Fluoxetine effects in a new transgenic model of depression. In Posters (French), P2T Pharmacology and Physiology Association meeting. (France)
• Cryan J.F., Mombereau C., Vassout A. (2005) The Tail Suspension Test As A Model For Assessing Antidepressant Activity: Review Of Pharmacological And Genetic Studies In Mice. Neurosci Biobehav Rev. 2005;29(4-5):571-625. (Switzerland)
• Strekalova T., Spanagel R., Bartsch D., Henn F.A., Gass P. (2004)Stress-Induced Anhedonia in Mice is Associated with Deficits in Forced Swimming. Neuropsychopharmacology,29(11):2007-17. (Germany)
• Mombereau C., Kaupmann K., Froestl W., Sansig G., van der Putten H., Cryan J.F. (2004)Genetic and Pharmacological Evidence of a Role for GABAB Receptors in the Modulation of Anxiety- and Antidepressant-Like Behavior. Neuropsychopharmacology,29(6):1050-62. (Switzerland)
Dieser Test erlaubt die Auswertung der psychotropischen Wirkung von Medikamenten (Antidepressiver, Sedativer...). Es ist eine einfache, schnelle (max. 6 Minuten) und schmerzlose Methode.
Gemessen wird die Aktivität einer am Schwanz aufgehangenen Maus, die Ihrer Situation entkommen will. Während dem Test werden die Bewegungen der Maus aufgenommen und die Kraft und die Leistung berechnet.
Dieser Test von BIOSEB ist völlig automatisiert. Das komplette System besteht aus der Aufhängevorrichtung (3 Mäuse pro Vorrichtung) und der Software zur Steuerung, Aufnahme, und Analyse des Experimentes.
Die Software läuft unter Windows XP und zeigt 3 Parameter an: Immobilitätszeit, Energie und Leistung.
Die Ergebnisse werden anschliessend mit Tabellen und Balkendiagrammen dargestellt. Die Daten können zusätzlich in andere Softwares wie MS-Excel zur weiteren Analyse übertragen werden.
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Aufnahmerate
1000 Hz
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