Eine einfache Methode für die Muskelkraftmessung von Nagetieren und die Einflussquantifizierung von Drogen, Toxinen, Krankheiten und anderen Nervenschäden. Der Grip-Test (auch Greiftest genannt) wird oft mit dem ROTAROD Motorikkoordinationstest kombiniert: ein normal koordiniertes Subjekt wird bei mangelnder Muskelkraft nur mittelmäßige Ergebnisse im ROTAROD-Test zeigen.
Miller et al. (2010) ENU Mutagenesis Reveals a Novel Phenotype of Reduced Limb Strength in Mice Lacking Fibrillin 2. PLoS ONE 5(2):e9137 (mouse, UK)
Dudra-Jastrzebska et al. (2009) Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: An isobolographic analysis. Eur. J. Pharmacol. 605(1-3): 87-94. (mouse, Poland, UK)
Dupuis L et al. (2009) Muscle Mitochondrial Uncoupling Dismantles Neuromuscular Junction and Triggers Distal Degeneration of Motor Neurons. PLoS ONE 4(4):e5390.(mouse, France)
Kozinska J et al (2009) Spironolactone potentiates the protective action of some selected antiepileptic drugs against maximal electroshock-induced seizures in mice. Annales UMCS, Pharmacia. 22(1):123-134. (mouse, Poland)
Lambertsen KL et al. (2009) Microglia Protect Neurons against Ischemia by Synthesis of Tumor Necrosis Factor. J. Neurosci. 29(5):1319-1330. (BIO-GT3, Mouse, Denmark, Sweden).
Luszczki JJ et al. (2009) N-(anilinomethyl)-p-isopropoxyphenylsuccinimide potentiates the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock-induced seizure model Neurosci. Res. 64(3):267-272. (mouse, Poland, Armenia)
E Wojdaas, A Wlaza, PN Patsalosb & JJ Luszczkia. Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6 Hz psychomotor seizure model In Epilepsy Research 2009 Jul 10.
JJ Luszczkia, SL Kocharovc & SJ Czuczwara. N-(anilionomethyl)-p-isopropoxyphenylsuccinimide potentiates the anticonvulsant action of phenobarbital and valproat in the mouse maximal electroshock-induced seizure model In Journal of Neuroscience Research 2009 Jul
JM Allen, L Zamurs, B Brachvogel, U Schötzer-Schrehardt & al. Mice Lacking the Extracellular Matrix Protein WARP Develop Normally but Have Compromised Peripheral Nerve Strucure and Function. The Journal of Biological Chemistry. 2009 Mars 11.
Akhtar M et al. (2008) Effect of thioperamide on oxidative stress markers in middle cerebral artery occlusion model of focal cerebral ischemia in rats. Human & Experimental Toxicology. 27(10):761-767. (rat, India)
Bhandari U et al. (2008) Protective effect of aqueous extract of Embelia ribes Burm fruits in middle cerebral artery occlusion-induced focal cerebral ischemia in rats. Indian J. Pharmacol. 40(5):215-220. (rat, India)
Luszczki JJ. (2008) Amiloride enhances the anticonvulsant action of various antiepileptic drugs in the mouse maximal electroshock seizure model. J Neural Transm. 116(1):57-66. (mouse, Poland)
Davies J et al. (2008) Wild-type PABPN1 is anti-apoptotic and reduces toxicity of the oculopharyngeal muscular dystrophy mutation. Hum. Mol. Genet. 17(8):1097-1108 (mouse, UK)
Ferrer-Alcon M (2008) Low intensity exercise attenuates disease progression and stimulates cell proliferation in the spinal cord of a mouse model with progressive motor neuronopathy. Neuroscience 152(2):291-295. (Mouse, Switzerland)
Jaarsma D et al. (2008) Neuron-Specific Expression of Mutant Superoxide Dismutase Is Sufficient to Induce Amyotrophic Lateral Sclerosis in Transgenic Mice. J. Neurosci. 28(9):2075-2088 (mouse, Netherlands)
Luszczki JJ. (2008) Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. Naunyn Schmiedebergs Arch Pharmacol. 378(5):483-92. (mouse, Poland)
Luszczki JJ et al. (2008) Agmatine enhances the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock seizure model. Journal of Neural Transmission. 115(11):1485-94. (mouse, Poland)
Luszczki J et al. (2008) Effects of amlodipine, diltiazem, and verapamil on the anticonvulsant action of topiramate against maximal electroshock-induced seizures in mice. Can. J. Physiol. Pharm. 86(3):113-121 (mouse, Poland)
Luszczki J et al. (2008) Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy. Eur. J. Pharmacol. 595(1-3):13-21 (mouse. Poland)
Mandillo S et al. (2008) Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study. Physiol. Genomics 34:243-255 (LE8200, mouse, Eumorphia protocols, Germany, France, UK, Italy)
Senechal et al. (2008) Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning. Behav. Brain Res. 186(1):126-132 (mouse, Ireland)
Teuling E et al. (2008) A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice. Human Molecular Genetics. 17(18):2849-2862. (mouse, The Netherlands)
Filliat P et al. (2007) Long-term behavioral consequences of soman poisoning in mice. Neurotoxicology. 28(3):508-519 (mouse, France)
Ling et al. (2007) Behavioral and pharmacological description of oxaliplatin-induced painful neuropathy in rat. Pain. 218(3):225-234 (rat, France)
Luszczki J et al. (2007) Effects of three calcium channel antagonists (amlodipine, diltiazem and verapamil) on the protective action of lamotrigine in the mouse maximal electroshock-induced seizure model. Pharmacol. Rep. 59:672-682 (mouse, Poland)
Luszczki J et al. (2007) Imperatorin enhances the protective activity of conventional antiepileptic drugs against maximal electroshock-induced seizures in mice. Eur. J. Pharmacol. 574(2-3):133-139 (mouse, Poland)
Rouaux et al. (2007) Sodium Valproate Exerts Neuroprotective Effects In Vivo through CREB-Binding Protein-Dependent Mechanisms But Does Not Improve Survival in an Amyotrophic Lateral Sclerosis Mouse Model. J. Neurosci. 27(21):5535-5545 (mouse, France)
Sahly I et al. (2007) 5-HT1A-iCre, a new transgenic mouse line for genetic analyses of the serotonergic pathway. Mol. Cell. Neurosci. 26(1):27-35 (mouse, France)
Senechal et al. (2007) Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice. J. Neurochem. 102(6):1928-1940 (mouse, Ireland)
Suelves M et al. (2007) uPA deficiency exacerbates muscular dystrophy in MDX mice. J. Cell. Biol. 178(6):1039-1051 (Mouse, Spain)
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Davies JE (2006) Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy. Human Molecular Genetics 2006 15(1):23-31. (Mouse, UK)
Luszczki JJ et al. (2006) Characterization of the Anticonvulsant, Behavioral and Pharmacokinetic Interaction Profiles of Stiripentol in Combination with Clonazepam, Ethosuximide, Phenobarbital, and Valproate Using Isobolographic Analysis. Epilepsia 47(11): 1841-1854. (Mouse, Poland)
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Die Version 3+ des BIOSEB Greiftests präsentiert mehrere exklusive Funktionalitäten::
• Ein einziges Instrument für Ratten und Mäuse, selbstständig oder in Verbindung mit einem PC oder einem Drucker anwendbar
• Verfügbare Zuberhörteile für die Messung auf Vorder- und Hinterpfoten, oder auf allen vier Pfoten gleichzeitig, Gitter- oder Stangenversion (siehe Abbildung nebenan)
• Einfache Benutzung und Kalibriereung (siehe Tutorial).
• NEU und einzigartig : interne Statistikberechnungen. Eine neue Entwicklung von BIOSEB erlaubt die direkte Berechnung der Durchschnittskraft, der mittleren Abweichung und der Variabilität für mehrere Subjektgruppen und bis zu 100 Tieren.
• Superschnelle Aufzeichnungsrate (1000 Hz), um die Wiederholbarkeit der Normal- und Maximalkraftmessungzu zu gewährleisten.
• Sehr zuverlässige Sensoren mit 0.2 Gramm Genauigkeit für vollen Messbereich und einer feinen Auflösung (benutzerdefinierbar bis zu 0.0001 Gramm).
• Interner Speicher: bis zu 100 Messwerten können für einen späteren Ausdruck oder Auswertung automatisch oder manuell gespeichert werden.
• Messdaten werden als zeitgestempelte Tabelle gespeichert
• Mit dem integrierten RS232-Port können Daten zu einem PC oder einem Drucker übertragen werden.
• Die optionale BIOSEB RSIC Software erlaubt die direkte Datenübertragung in eine MS-Excel Arbeitsmappe.
Inkl.: 1 Gitter oder Stange (nach Wahl unter den dargestellten Modellen), 1 RS232-Port, 1 Batterie, 1 Benutzerhandbuch Nach Bedarf : spezifische Modelle
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Information published on this Web Site as well as services, product specifications, availability and prices are subject to change without notice. BIOSEB may also make improvements and/or changes in the products and/or the programs described in this Web Site at any time without notice.
BIOSEB has made reasonable efforts to verify that the information in this Web site was accurate when first published. Such information may contain errors or omissions, however, and it is subject to change without notice. Bioseb does not undertake to update this information to include any such changes or to correct errors or omissions. Bioseb assumes no responsibility for any use of the information in this Web site or for any infringement of patents or other rights of third parties that may result. Certain information may be country-specific and may not apply in all countries.
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