Eine einfache Methode für die Muskelkraftmessung von Nagetieren und die Einflussquantifizierung von Drogen, Toxinen, Krankheiten und anderen Nervenschäden. Der Grip-Test (auch Greiftest genannt) wird oft mit dem ROTAROD Motorikkoordinationstest kombiniert: ein normal koordiniertes Subjekt wird bei mangelnder Muskelkraft nur mittelmäßige Ergebnisse im ROTAROD-Test zeigen.
Corrochano S., Renna M., Carter S., Chrobot N., Kent R., Stewart M. et al. (2012) α-Synuclein levels modulate Huntington's disease in mice. Hum. Mol. Genet., 21 (3):485-494. (U.K.)
Simard M., Tsymbalyuk O., Keledjian, Ivanov A., Ivanova S., Gerzanich V. (2012) Comparative effects of glibenclamide and riluzole in a rat model of severe cervical spinal cord injury. Experimental Neurology, 233(1):566–574. (USA)
Nieoczym D., Socała K., Łuszczki J., Czuczwar S., Wlaz P. (2012) Influence of sildenafil on the anticonvulsant action of selected antiepileptic drugs against pentylenetetrazole-induced clonic seizures in mice. J Neural Transm. [Epub ahead of print]. (Poland)
Luszczki J., Filip D., Florek-Luszczki M. (2012) Interactions of pregabalin with gabapentin, levetiracetam, tiagabine and vigabatrin in the mouse maximal electroshock-induced seizure model: A type II isobolographic analysis. Epilepsy Research, 98(2–3):148–156. (Poland)
Luszczki J., Kominek M., Florek-Luszczki M., Tchaytchian D., Kocharov S., Zolkowska D. (2012) Influence of N-hydroxymethyl-p-isopropoxyphenylsuccinimide on the anticonvulsant action of different classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model. Epilepsy Res. [Epub ahead of print]. (Poland)
Lauritz B., Siebel A.L., Guille V., Jefferies A.J., Wlodek M.E. (2012) Growth restriction alters adult spatial memory and sensorimotor gating in a sex-specific manner. Journal of Developmental Origins of Health and Disease, 3:59-68. (Australia)
Laloux C., Petrault M., Lecointe C., Devos D., Bordet R. (2012) Differential susceptibility to the PPAR-γ agonist pioglitazone in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine rodent models of Parkinson's disease. Pharmacological Research, 65(5):514–522. (France)
Garbuzova-Davis S., Rodrigues M., Mirtyl S., Turner S., Mitha S., Sodhi J. et al. (2012) Multiple Intravenous Administrations of Human Umbilical Cord Blood Cells Benefit in a Mouse Model of ALS. PloS One, 7(2), e31254. (USA)
Blaise S., Kneib M., Rousseau A., Gambino F., Chenard M.-P., Messadeq N. et al. (2012) In Vivo Evidence That TRAF4 Is Required for Central Nervous System Myelin Homeostasis. PloS One, 7(2), e30917. (France)
Gasior M., Socała K., Nieoczym D., Wlaź P. (2012) Clavulanic acid does not affect convulsions in acute seizure tests in mice. Journal of Neural Transmission, 119(1), 1-6. (Poland)
2011 PUBLICATIONS
Domanskyi A., Geißler C., Vinnikov I., Alter H., Schober A., Vogt M. et al. (2011) Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models. The FASEB Journal, 25(9):2898-2910. (Germany)
Panayotis N., Pratte M., Borges-Correia A., Ghata A., Villard L., Roux J.-C. (2011) Morphological and functional alterations in the substantia nigra pars compacta of the Mecp2-null mouse. Neurobiology of Disease, 41(2):385–397. (France)
Davies J., Rubinsztein D. (2011) Over-expression of BCL2 rescues muscle weakness in a mouse model of oculopharyngeal muscular dystrophy. Human Molecular Genetics, 20(6):1154–1163. (U.K.)
Steiner M., Lecourt H., Rakotoariniaina A., Jenck F. (2011) Favoured genetic background for testing anxiolytics in the fear-potentiated and light-enhanced startle paradigms in the rat. Behavioural Brain Research, 221(1):34–42. (Switzerland)
Ganay T., Boizot A., Burrer R., Chauvin J.P., Bomont P. (2011) Sensory-motor deficits and neurofilament disorganization in gigaxonin-null mice. Molecular Neurodegeneration, 6:25. (France)
Roberson D.P., Binshtok A.M., Blasl F., Bean B.P., Woolf C.J. (2011) Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review. British Journal of Pharmacology, 164(1):48–58. (USA)
Carre-Pierra M., Lafoux A., Tanniou G., Chambonnier L., Divet A., Fougerousse F. et al. (2011) Pre-clinical study of 21 approved drugs in the mdx mouse. Neuromuscular Disorders, 21(5):313–327. (France)
Nozaki C., Vergnano A.M., Filliol D., Ouagazzal A.-M., Le Goff A., Carvalho S. et al. (2011) Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit. Nature Neuroscience, 14:1017–1022. (France)
Steiner M., Lecourt H., Strasser D., Brisbare-Roch C., Jenck F. (2011) Differential Effects of the Dual Orexin Receptor Antagonist Almorexant and the GABAA-α1 Receptor Modulator Zolpidem, Alone or Combined with Ethanol, on Motor Performance in the Rat. Neuropsychopharmacology, 36:848–856. (Switzerland)
van der Vaart T., van Woerden G.M., Elgersma Y., de Zeeuw C. I., Schonewille M. (2011) Motor deficits in neurofibromatosis type 1 mice: the role of the cerebellum. Genes, Brain and Behavior, 10(4):404–409. (The Netherlands)
Lamballe F., Genestine M., Caruso N., Arce V., Richelme S., Helmbacher F. et al. (2011) Pool-Specific Regulation of Motor Neuron Survival by Neurotrophic Support. The Journal of Neuroscience, 31(31):11144-11158. (France)
Inácio A., Ruscher K., Leng L., Bucala R., Deierborg T. (2011) Macrophage migration inhibitory factor promotes cell death and aggravates neurologic deficits after experimental stroke. Journal of Cerebral Blood Flow & Metabolism, 31:1093–1106. (Sweden)
Hourez R., Servais L., Orduz D., Gall D., Millard I., de Kerchove d'Exaerde A. et al. (2011) Aminopyridines Correct Early Dysfunction and Delay Neurodegeneration in a Mouse Model of Spinocerebellar Ataxia Type 1. The Journal of Neuroscience, 31(33):11795-11807. (Belgium)
Quintard H., Borsotto M., Veyssiere J., Gandin C., Labbal F., Widmann C. et al. (2011) MLC901, a Traditional Chinese Medicine protects the brain against global ischemia. Neuropharmacology, 61(4):622–631. (France)
Luszczkia J., Misiuta-Krzesinskaa M., Florekc M., Tutkad P., Czuczwar S. (2011) Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice. Pharmacology Biochemistry and Behavior, 98(2):261–267. (Poland)
Bojados M., Jamon M. (2011) Exposure to hypergravity during specific developmental periods differentially affects metabolism and vestibular reactions in adult C57BL /6j mice. European Journal of Neuroscience, 34(12):2024–2034. (France)
Luszczki J., Andres-Mach M., Barcicka-Klosowska B., Florek-Luszczki M., Haratym-Maj A., Czuczwar S. (2011) Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35(8):1870–1876. (Poland)
2010 PUBLICATIONS
Ruscher K., Erickson A., Kuric E., Inácio A., Wieloch T. (2010) Effects of chronic Clozapine administration on apolipoprotein D levels and on functional recovery following experimental stroke. Brain Research, 1321:152-163. (Sweden)
Ishizaki T., Erickson A., Kuric E., Shamloo M., Hara-Nishimura I., Lourenço Inácio A. et al. (2010) The asparaginyl endopeptidase legumain after experimental stroke. Journal of Cerebral Blood Flow & Metabolism, 30:1756–1766. (Sweden)
Chambon C., Duteil D., Vignaud A., Ferry A., Messaddeq N., Malivindi R. et al. (2010) Myocytic androgen receptor controls the strength but not the mass of limb muscles. PNAS, 107(32):14327-14332. (France)
Vignaud A., Ferry A., Huguet A., Baraibar M., Trollet C., Hyzewicz J. et al. (2010) Progressive skeletal muscle weakness in transgenic mice expressing CTG expansions is associated with the activation of the ubiquitin–proteasome pathway. Neuromuscular Disorders, 20(5):319–325. (France)
Miller G., Neilan M., Chia R., Gheryani N., Holt N., Charbit A. et al. (2010) ENU Mutagenesis Reveals a Novel Phenotype of Reduced Limb Strength in Mice Lacking Fibrillin 2. PloS One, 5(2), e9137. (U.K.)
Luszczki J., Cioczek J., Kocharov S., Andres-Mach M., Kominek M., Zolkowska D. (2010) Effects of three N-(carboxyanilinomethyl) derivatives of p-isopropoxyphenylsuccinimide on the anticonvulsant action of carbamazepine, phenobarbital, phenytoin and valproate in the mouse maximal electroshock-induced seizure model. European Journal of Pharmacology, 648(1–3):74–79. (Poland)
Nieoczym D., Łuszczki J., Czuczwar S., Wlaz P. (2010) Effect of sildenafil on the anticonvulsant action of classical and second-generation antiepileptic drugs in maximal electroshock-induced seizures in mice. Epilepsia, 51(8):1552–1559. (Poland)
Luszczkia J., Filipa D., Czuczwar S. (2010) Additive interactions of pregabalin with lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model: A type I isobolographic analysis for non-parallel dose–response relationship curves. Epilepsy Research, 91(2–3):166–175. (Poland)
Luszczki J., Czuczwar P., Cioczek-Czuczwar A., Dudra-Jastrzebska M., Andres-Mach M., Czuczwar S. (2010) Effect of arachidonyl-2′-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 34(1):18–25. (Poland)
Luszczki J. (2010) Interaction of pregabalin with carbamazepine in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves. Advances in Medical Sciences, 55(1):43-52. (Poland)
Luszczki J., Trojnar M., Ratnaraj N., Patsalos P., Czuczwar S. (2010) Interactions of stiripentol with clobazam and valproate in the mouse maximal electroshock-induced seizure model. Epilepsy Research, 90(3):188–198. (Poland)
Braunstein K., Eschbach J., Ròna-Vörös K., Soylu R., Mikrouli E., Larmet Y. et al. (2010) A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons. Hum. Mol. Genet., 19(22):4385-4398. (Germany)
Mallm J.P., Tschäpe J.A., Hick M., Filippov M.A., Müller U.C. (2010)Generation of conditional null alleles for APP and APLP2. Genesis, 48(3):200–206. (Germany)
Luszczki J., Antkiewicz-Michaluk L., Raszewski G., Czuczwar S. (2010) Interactions of 1-methyl-1,2,3,4-tetrahydroisoquinoline with lamotrigine, oxcarbazepine, pregabalin, and topiramate in the mouse maximal electroshock-induced seizure model: A type I isobolographic analysis. Epilepsy Research, 89(2–3):207–219. (Poland)
van Til N., Stok M., Aerts Kaya F., de Waard M., Farahbakhshian E., Visser T. et al. (2010) Lentiviral gene therapy of murine hematopoietic stem cells ameliorates the Pompe disease phenotype. Blood, 115(26):5329-5337. (The Netherlands)
Pichon X., Wattiez A., Becamel C., Ehrlich I., Bockaert J., Eschalier A. et al. (2010) Disrupting 5-HT2A Receptor/PDZ Protein Interactions Reduces Hyperalgesia and Enhances
SSRI Efficacy in Neuropathic Pain. moleculartherapy.org., 18(8):1462–1470. (France)
Die Version 3+ des BIOSEB Greiftests präsentiert mehrere exklusive Funktionalitäten::
• Ein einziges Instrument für Ratten und Mäuse, selbstständig oder in Verbindung mit einem PC oder einem Drucker anwendbar
• Verfügbare Zuberhörteile für die Messung auf Vorder- und Hinterpfoten, oder auf allen vier Pfoten gleichzeitig, Gitter- oder Stangenversion (siehe Abbildung nebenan)
• Einfache Benutzung und Kalibriereung (siehe Tutorial).
• NEU und einzigartig : interne Statistikberechnungen. Eine neue Entwicklung von BIOSEB erlaubt die direkte Berechnung der Durchschnittskraft, der mittleren Abweichung und der Variabilität für mehrere Subjektgruppen und bis zu 100 Tieren.
• Superschnelle Aufzeichnungsrate (1000 Hz), um die Wiederholbarkeit der Normal- und Maximalkraftmessungzu zu gewährleisten.
• Sehr zuverlässige Sensoren mit 0.2 Gramm Genauigkeit für vollen Messbereich und einer feinen Auflösung (benutzerdefinierbar bis zu 0.0001 Gramm).
• Interner Speicher: bis zu 100 Messwerten können für einen späteren Ausdruck oder Auswertung automatisch oder manuell gespeichert werden.
• Messdaten werden als zeitgestempelte Tabelle gespeichert
• Mit dem integrierten RS232-Port können Daten zu einem PC oder einem Drucker übertragen werden.
• Die optionale BIOSEB RSIC Software erlaubt die direkte Datenübertragung in eine MS-Excel Arbeitsmappe.
Inkl.: 1 Gitter oder Stange (nach Wahl unter den dargestellten Modellen), 1 RS232-Port, 1 Batterie, 1 Benutzerhandbuch Nach Bedarf : spezifische Modelle
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Information published on this Web Site as well as services, product specifications, availability and prices are subject to change without notice. BIOSEB may also make improvements and/or changes in the products and/or the programs described in this Web Site at any time without notice.
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