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PLACE PREFERENCE CAGE
(Model: LE890 - for rats)
A standard experimental chamber for automated or manual assessment of conditioned place preference and aversion in rodents (rats or mice), two tests widely used for screening the reinforcing properties of drugs (or natural stimuli) as well as for investigating the brain neurobiological systems implicated in reward and addition.

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  • PHARMACOLOGIE CHU HOPITAL SUD Grenoble, France
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! NEW RESEARCH WORK ! A recent publication by E. Barbier, H. Houchi, V. Warnault, O. Pierrefiche, M. Daoust et al. in "Neuroscience" highlights the merits of using Bioseb's Place Preference Cage: Effects of prenatal and postnatal maternal ethanol on offspring response to alcohol and psychostimulants in long evans rats

Effects of prenatal and postnatal maternal ethanol on offspring response to alcohol and psychostimulants in long evans rats
E. Barbier, H. Houchi, V. Warnault, O. Pierrefiche, M. Daoust et al.
Université de Picardie Jules Verne, Groupe de Recherche sur l'alcool et les Pharmacodépendances, Equipe région INSERM 24 (ERI24), Amiens, France.
Published in "Neuroscience" (2009-06-30)


An important factor that may influence addiction liability is exposure during the early life period. Exposure to ethanol, early in life, can have long-lasting implications on brain function and drugs of abuse response later in life. In the present study we investigated the behavioral responses to ethanol and to psychostimulants in Long Evans rats that have been exposed to pre- and postnatal ethanol. Since a relationship between heightened drug intake and susceptibility to drug-induced locomotor activity/sensitization has been demonstrated, we tested these behavioral responses, in control and early life ethanol-exposed animals. The young adult male and female progeny were tested for locomotor response to alcohol, cocaine and d-amphetamine. Sedative, rewarding effects of alcohol and alcohol consumption were measured. Our results show that early life ethanol exposure behaviorally sensitized animals to subsequent ethanol and psychostimulants exposure. Ethanol-exposed animals were also more sensitive to the hyperlocomotor effects of all drugs of abuse tested and to those of the dopamine receptor agonist apomorphine. Locomotor sensitization to repeated injections of cocaine was facilitated in ethanol-exposed animals. Ethanol-induced conditioned place preference was also facilitated in ethanol-exposed animals. Ethanol consumption and preference were increased after early life ethanol exposure and this was associated with decreased sensitivity to the sedative effects of ethanol. The altered behavioral responses to drugs of abuse were associated with decreased striatal dopamine transporter and hippocampal NMDAR binding. Our results outline an increased vulnerability to rewarding and stimulant effects of ethanol and psychostimulants and support the epidemiological and clinical data that suggested that early chronic exposure to ethanol may increase the propensity for later self-administration of ethanol or other substances.
Bioseb's Place Preference Cage for rats and mice : View from above
Place Preference Cage : View from above

Presentation

BIOSEB Place Preference Box is a standard experimental chamber for automated assessment of conditioned place preference and aversion in rodents, two tests widely used for screening the reinforcing properties of drugs (or natural stimuli) as well as for investigating the brain neurobiological systems implicated in reward and addition.

The purpose of the Conditioned Place Preference test is to characterize the rewarding potential of a drug or other experimental condition.

The procedure involves operant conditioning of a preference for a particular environment that has been consistently paired with a subjective internal state induced by the tested substance or condition. If a drug has marked rewarding properties, the animal will spend more time in the compartment with which it was paired when subsequently tested without the drug. The conditioned place preference procedure is classically used for a long time to test the addictive liability of putative drugs of abuse in research as well as in pharmaceutical industry. The procedure may also be modified to determine whether genetically modified animals are more or less sensitive to the reinforcing effects of a drug.

Bioseb's Place Preference Cage for rats and mice : Optional PPCWIN Software
Place Preference Cage : PPCWIN Software
Operating principle

The experimental box consists of two Perspex compartments of the same size interconnected by a central grey corridor.

The compartments can be differentiated by both visual and tactile cues: the colour of the walls in each compartment (white or black) and the texture of the floors (smooth or rough). The box is provided with transparent frontal walls which may be covered with extractable opaque covers (included). Manually operated sliding doors are provided to manage the access to the two compartments from the corridor.

Optional dedicated software

The experimental box can be supplied with or without automatic animal position detection system. The automated animal position detection can be carried out by the SMART video-tracking system or by a weight transducer system which is associated to the PC-based control software PPCWIN. Click here to see the product page of the PPCWIN software!

Main features

• Detects putative reinforcing properties of drugs
• Involves associative learning
• Different versions available for rats and mice
• Supplied with or without automatic position detection system
• Allows a multiple combination between the visual and tactile cues defining each compartment
• Weight transducer technology allows optimizing animal detection in low-contrast conditions
• Needs PC for automated storage and analysis of the data
• Up to 8 stations can be connected at once to PC through a single cable
Parameters Measured

• Total number of entries into the compartments
• % distribution of the number of entries into the different compartments
• Permanence time in each compartment
• % permanence time in respect to the total duration of the experiment
• Chronological sequence of animal displacements

Domains of application

• Drug screening
• Compulsive behaviors
• Phenotyping
• Drug dependence

Publications (Click on an article to show details and read the abstract)


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Experimental Box Dimensions - RAT Compartments: 300 (W) x 300 (D) x 340 (H) mm,
Corridor: 80 (W) x 100 (D) x 340 (H) mm and
Doors: 100 (W) x 140 (H)
Experimental Box Dimensions - MOUSE Compartments: 100 (W) x 130 (D) x 130 (H) mm,
Corridor: 72 (W) x 72 (D) x 130 (H) mm and
Doors: 60 (W) x 60 (H) mm
Position detection technique Weight transducers
Material Composition Perspex
Connection of several units
to PC
Neither PC interface nor PC card are required.
One cable connects all units to the PC.
Certifications CE Compliant
Power Requirement 110/220 V, 50/60 Hz

Model:
LE890
Place Preference Cage
for rats Contact us

Related products:
LE895
Spatial place preference Test
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LE891
Place Preference Cage
for mice Contact us
LE892
Place Preference Cage
for rats - with automatic position detection Contact us
LE893
Place Preference Cage
for mice - with automatic position detection Contact us

Accessories :
PPCWIN
PPCWIN software
Contact us
Print version

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