! NEW RESEARCH WORK !
A recent publication
by S Ni, Z Ling, X Wang, Y Cao, T Wu, R Deng, JL Crane et al in "Nature Communications" highlights the merits of using Bioseb's SMALGO: SMall animal ALGOmeter
: Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice
SMall Animal ALGOmeter:
Demonstration on a rat
Bioseb’s SMALGO (SMall animal ALGOmeter) is a new pressure-based analgesimeter especially designed for small animals like rats and mice.
Bioseb’s SMALGO fits on your finger (thumb or index) and allows you to easily apply a force or pressure on the desired location. Designed for OA quantification, it is generally used on the knee joint or on the lumbar vertebrae for low back pain assessment.
The threshold sensitivity of the animal (rats or mice) is quickly and reliably determined by applying a progressive force. The threshold is immediately displayed
on the electronic device and can be shown in Grams, Newton, Ibs or Oz.
The instrument is composed of :
• The stimulator unit
designed to be attached to the thumb delivered with 3 stimulation tips (3,5 and 8 mm in diameter)
• A new interface table casing
: This control unit is now the same as other mechanical pain stimulation instruments from Bioseb (Rodent Pincher, Electronic Von Frey..). This compatibility allows the use of one unit for several instruments
(economical solution). Moreover, a new feature is available : the Smalgo is now able to deliver TTL signals
for electrophysiology applications.
• The BIO-CIS Software
for connection to a computer.
The operator adjusts the algometer (analgesimeter) to the thumb and applies a progressive pressure to the relevant location on the animal, as if he was applying the pressure directly with his own finger. The operator increases the stimulation until he obtains a reaction from the animal (scream, shudder...) and then stops the stimulation. The maximum force value is automatically saved
and displayed on the screen of the instrument.
The sensor provides a capacity of 1500 grams with an accuracy of 0,1%, allowing reliable measurements for a large amount of applications on both rats and mice
. It is possible to set an alarm to be triggered when a certain force value is reached, in oder to protect the animal (not overstimulate them) as well as the sensor (not overload it).
You can also connect the Smalgo to ourBIO-CIS software
. There are two ways of using Smalgo with this software :
• The Smalgo can be connected directly to the software
during the experiment. Bio-Cis will display force curves in real-time during every measurement, which is a great help to ensure repeatability during your stimulations and to validate your data.
• You can also export all measurements stored in the inner memory
of the Smalgo after the experiment.
In both cases, you will furthermore be able to export your results to an Excel file.
• Easy-to-use and reliable
• Works for both rats and mice
• Can be used to determine pain threshold with a progressive force
• Able to send TTL results for electrophysiology
Domains of application
• Drug screening
• Post-operative pain
• Laboratoire Biocodex, France
• Rush University, Chicago, USA
• North Carolina State University, USA
• University Complutense of Madrid, Madrid, Spain
• Chosun University, Korea
• Carry case, mains adaptor 110/220 V
• Control unit and its sensor (cable is 1 meter long)
• 3 sensor tips 3, 5, 8 mm diam.
• Software BIO-CIS included to display force curves and transfert data under MS Excel data sheet
• RS-232-USB cable to plug it to a laptop under Windows OS
• USB footswitch to reset the display hand-free
BIO-CIS Software for the SMall animal ALGOmeter
: The Smalgo control unit is now the same as other mechanical pain stimulators from Bioseb.
• Economical solution
if you want to buy several mechanical pain stimulators.
• All in one instrument
reducing space in your laboratory.
• Easy maintenance
: Only one instrument to re-calibrate.
Also, for users already owning the Bioseb Von frey (EVF4) or Pincher, the SMALGO sensor is available as an “add on” part to their instrument. (Ref: SMALGO-SPIP ).
: For laboratories that need compatibility between Smalgo and Electrophysiology
, Bioseb allows the instrument to send TTL Signals
between 0 and 5 volts.
• Smalgo now enables you to pair electrophysiology signals and pain stimulation.
• The operator can define a limit in force
at which the Smalgo will send the trigger. The trigger can be sent when reaching one or several values. This is a very convenient feature for a large number of protocols.
• The TTL trigger is easy to set up
directly in the menu of the apparatus (without needing to connect to the software)
• A sound and a light
can be activated at a specific force. Several possibilities are available. Do not hesitate to contact us for this option.
: With Smalgo, it is now possible to reset the value (tar/reset to zero) with a foot switch, allowing the operator to keep his both hands to manipulate the animal. The foot switch is systematically delivered with the Smalgo.
The Bioseb’s BIO-CIS software sends data acquired via the SMall Animal AlGOmeter into a MS Excel sheet using the RS232-USB port. Easy to set up, this software interface uses the full power of MS Excel functions, to let you create statistical tables and graphics.
New system! AlgoKit
A COMPLETE SOLUTION FOR ALL SITUATIONS
INVOLVING PAIN MEASUREMENT ON RODENTS
MULTIPLE PROBES, ONE CONTROL UNIT AND SOFTWARE APPLICATION
You may consider our new ALGOKIT package to expand the scope of your possibilities. In order to offer an answer to all your requests regarding different situations of pain measurement, Bioseb is proud to present an innovative, complete solution combining our Static Weight Bearing
, including its state-of-the art touchscreen, color console, with up to 3 sensors to be chosen among our Electronic Von Frey
, Rodent Pincher
and Small animal Algometer
, all connected to one unique Control Unit
• Flexible instrument when a quantitative sensory testing (QST) is needed
• Compatible with our BIO-CIS software to improve repeatability in nociceptive testing