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PPCWIN SOFTWARE
(Model: PPCWIN)
Easy-to-use and complete software for monitoring Conditioned Place Preference (or aversion) tests and Black and White experiments (for anxiety)

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! NEW RESEARCH WORK ! A recent publication by L.L. Ma, T. Freret, M. Lange, J. Bourgine, A. Coquerel et al. in "Fundamental and Clinical Pharmacology" highlights the merits of using Bioseb's PPCWIN software: Benzodiazepines increase the reward effects of buprenorphine in a conditioned place preference test in the mouse

Benzodiazepines increase the reward effects of buprenorphine in a conditioned place preference test in the mouse
L.L. Ma, T. Freret, M. Lange, J. Bourgine, A. Coquerel et al.
Normandie University, Caen, France
Published in "Fundamental and Clinical Pharmacology" (2014-04-17)


Buprenorphine (BPN) is widely used as a substitution treatment for opioid addiction. Some cases of abuse and misuse, especially associated with various benzodiazepines (BZDs), have been described, and a previous study has shown that BZDs increase the sedative effect of BPN and decrease its anxiogenic properties. To investigate the reward effect that may lead to the abusive combination of BPN and BZD, we studied the influence of different doses of three BZDs extensively used with BPN by drug addicts on conditioned place preference behavior in mice. BPN (0.3, 1, 3 mg/kg) was injected subcutaneously into male mice alone or in combination with a BZD administered intraperitoneally: dipotassium clorazepate (CRZ; 1, 4, 16 mg/kg), diazepam (DAZ; 0.5, 1, 5 mg/kg), or bromazepam (BMZ; 0.5, 1, 3 mg/kg). Amphetamine (8 mg/kg) was used as a reference drug. Reward effects of BPN alone or in combination were measured in a conditioned place preference paradigm using an unbiased procedure. Our results showed that groups treated with BPN associated with different doses of diazepam and clorazepate, but not bromazepam, spent significantly more time in the drug-paired compartment compared to the group treated with BPN alone. Our study shows that joint consumption of diazepam and clorazepate, but not bromazepam, can increase the reward properties of BPN alone in mice. These results could help to explain the use of this type of drug combination in the drug addict population.

Presentation

PPCWIN is an easy-to-use and complete software for monitoring Conditioned Place Preference (or aversion) tests and Black and White experiments (for anxiety). It has been specially designed to work with the BIOSEB Automated Place Preference and Black and White boxes equipped with weight transducers for the automatic detection of animal position.

PPCWIN controls independently up to 8 experimental chambers. The system includes a test mode enabling immediate and reliable checking of the communication between the software and the experimental chambers.

Operating pinciple

The Place Preference and Black and White boxes are basically divided in two different compartments connected by a grey corridor/door, respectively. One experiment can be composed of several sessions, depending on the number of experimental groups and animals per group used in the study. PPCWIN is easy to configure as the user only needs to enter the desired duration of experiment and some specific information about the session (subject name, group…). During data acquisition, information about protocol state, animal position and current data can be visualized for each cage on the corresponding control window.

PPCWIN provides a raw data table with all the standard parameters for conditioned place preference and Black and White experiments (permanence time in the compartments, number of entries…) and a detailed chronological sequence of animal displacements for each session. A report table can be generated containing the results from different stored session. Data from the tables of result can be easily exported in formats widely used to perform complementary analysis.

Parameters Measured

• Total number of entries into the black, white and grey compartments
• % distribution of the number of entries into the different compartments
• Permanence time in each compartment
• % permanence time in respect to the total duration of the experiment
• Chronological sequence of animal displacements
• Latency to the first transition regardless to the initial position
• Experiment duration

Domains of application

• ANXIETY:
- The most prevalent of the psychiatric diseases
- Anxiety disorders

• REWARD AND ADDICTION:
- Compulsive behavior which is reinforced or rewarded
- Drug addiction
- Chronic drug abuse

Key features

• Easy-to-use software for standard conditioned place preference experiments
• For both place preference and black and white experiments
• A test mode enables immediate checking of the communication between the software and the experimental chambers
• Current animal position can be visualized in real-time during the acquisition of data
• Provides integrated results
• Tables of result easily exportable in Excel format for further analysis
• RS232 or USB port direct connection


Publications (Click on an article to show details and read the abstract)


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Computer requirements 2 GHz processor or higher (Celeron processor not supported), 2 Gb of RAM
Graphic Card Requirements 256 colours palette graphics card for 1024x768 pixels, 32-bit true colour RGB display
Communication Requirements 1 free USB for the protection key
1 free RS232 serial port for boxes connection (a USB-Serial adapter included in the software pack can be used when a RS-232 serial port is not available)
Software Requirements Windows 7 compatible operating system

Model:
PPCWIN
PPCWIN software
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