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INFRARED ACTIMETER
(Model: LE8816 - IR frame, 250 x 250 mm 16 x 16 IR beams )
Used to Measure SPONTANEOUS motor activity in an open field by mean of photoelectric Infra Red beams

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INSERM GENOPOLE EVRY (France)
UCB PHARMA BRUSSELS (Belgium)
KEYOBS ORLEANS (France)
CNRS BORDEAUX (Fr)
PIERRE FABRE TOURS (Fr)
CNRS NANCY (Fr)
INSERM MEDICAL SCHOOL ROUEN (Fr)
ICS ILKIRCH
INSERM PHARMACY SCHOOL ILKIRCH (Fr)
UNIVERSITY RENNES (Fr)
INSERM LILLE (Fr)
INSERM PHARMACY SCHOOL LYON (Fr)
CRESSA GRENOBLE (Fr)
GENEVA UNIVERSITY (SWITZERLAND)
INSERM NEUREVA MONTPELLIER (Fr)
UNIVERSITY AMIENS (Fr)
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! NEW RESEARCH WORK ! A recent publication by AL Mausset-Bonnefont, M Cren, R Vicente, J Quentin in "Arthritis Research & Therapy" highlights the merits of using Bioseb's Infrared Actimeter: Arthritis sensory and motor scale: predicting functional deficits from the clinical score in collagen-induced arthritis

Arthritis sensory and motor scale: predicting functional deficits from the clinical score in collagen-induced arthritis
AL Mausset-Bonnefont, M Cren, R Vicente, J Quentin
IRMB, University of Montpellier, INSERM, Montpellier, France
Published in "Arthritis Research & Therapy" (2019-12-04)


In the collagen-induced arthritis (CIA) mouse model, inflammation readouts are usually quantified using operator-dependent clinical scoring systems, and no systematic relationship with functional deficits has been detected. In this study, we extensively quantified sensory and motor deficits in CIA mice during natural disease progression and therapeutic treatment. Then, we used these data to build a scale to predict functional deficits on the basis of the classical clinical score.

Presentation

The BIOSEB Infrared (IR) Actimeter allows the study of spontaneous locomotor activity, rearings and optionally hole-board test parameters for exploration in rodents. A reliable system for easy and rapid drug screening and phenotype characterisation in both day and night lighting conditions.

Operating principle

The system is basically composed by a 2 dimensional (X and Y axes) square frame, a frame support and a control unit. Each frame counts with 16 x 16 infrared beams for optimal subject detection.
The system is completely modular: each frame may be used for evaluation of general activity (one or several animals), locomotor and stereotyped movements or rearings or exploration (nose-spoke detection in the hole-board option). The infrared photocell system can be set with up to 15 levels of sensitivity in order to adapt the frames to the typology of the animal (rats, mice). It can also be set to ignore the beams that are obstructed by objects (e.g. the walls/corners of the home cage).

Actitrack software for Infrared Actimeter, by Bioseb
Actitrack Software for Infrared Actimeter
Key features

Our Infra Red beams ACTIMETER shows some unique features as:
• Minimum maintenance required
• Minimum lighting conditions required
• Interchangeable frames can be used without distinction for either REAR, ACT or POKING modes
• Can be used without any computer (independent control units)

The frames can be controlled by the independent control units LE8825 or directly through the optional SEDACOM computer software.
The new SEDACOM 2.0 version provides an easy and convenient way to visualize and export the data on a computer for further analysis.
Optionally, the ACTITRACK software option may be used to analyse animal trajectories (distance, speed, permanence time in selected zones) and then provide additional complementary data to those obtained using the control units.

Parameters Measured

• Fast/Slow activity; i.e. movements with displacement (control unit)
• Fast/Slow stereotypies; i.e. movements without displacement (control unit)
• Fast/Slow rearings (control unit)
• Fast/Slow nose-spoke (control unit)
• Analysis of animal tracking: distance covered, speed, rearings, permanence time in selected zones, etc. (Actitrack)
• Intervals of inactivity (Actitrack)
• Time in zone (Actitrack)
• Distance travelled (Actitrack)
• Rearing behaviour events and duration (Actitrack)

You will find more details on the LE8811 Infra Red Actimeter system in the .pdf file enclosed

Infrared Actimeter Frame for rats and mice, by Bioseb
Infrared Actimeter Frame
LE8810 Actimeter includes the following items

• 2 x squared frames LE8816 with 22x22cm of internal space, each including 16 IR beam cells on each side (x ans y axis)
• 1 LE8818 to support the 2 frames
• 1 electronic data logger and control unit (LE8825) allowing the monitoring of 1 or 2 of the above frames. The large lcd display allows to set up the protocols (test duration, sampling time of data acquisition, animal activity threshold …), and to read the results of the activity, either “global”, surface or rearing, slow and fast movements, stereotypic moves, number of rearings…. A last set up allows using the LE8810 as a “hole board”.
• It is worth to remember that each individual sensors frame can be set as a “surface (x,y) actimeter”, or as a “rearing actimeter”. Thus allowing one LE8810 system to monitor 1 animal in the 3 dimensions (x,y,z) or 2 animals in (x,y) dimensions.

Domains of application:

• Evaluation of animal’s basal activity and its evolution with time
• Activity response to novelty or anxiogenic environment
• Activity response to pharmacological treatment, lesion or genetic modification
• Drug screening
• Phenotyping
• Parkinson disease
• Huntington disease
• Attention-Deficit Hyperactivity Disorder (ADHD)

Options

• LE8825: Data Logger (up to 200 hours memory, RS232 comm).
• LE8814: Transparent arena for 1 subject (4 walls for LE 8815), 440 x 440 mm (Open Field).
• LE8813: Transparent arena for 1 subject (4 walls for LE 8816), 210 x 210 mm (Open Field).
• LE8821: Transparent arena for 2 subjects (4 walls + divider for LE 8815), needs ActiTrack software.
• LE8823: Transparent arena for 2 subjects (4 walls + divider for LE 8816), needs ActiTrack software.
• LE8820: Hole-board accessory - Nose-Poke Base for LE 8815 Frame (16 holes, 2.4 diam., 1 cm depth).
• ACTITRACK Software for up to 32 frames (ie up to 64 animals) via the RS232 port of a PC



Publications (Click on an article to show details and read the abstract)

MOTOR CONTROL
- Motor Deficits -
Neuronal Gene Therapy for Friedreich Ataxia (2018)
Neuronal Gene Therapy for Friedreich Ataxia
F Piguet, C de Montigny, N Vaucamps, L Reutenauer, A Eisenmann, H Puccio
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France
Published in "Molecular Therapy" (2018-05-10)

Friedreich ataxia (FA) is a rare mitochondrial disease characterized by sensory and spinocerebellar ataxia, hypertrophic cardiomyopathy, and diabetes, for which there is no treatment. FA is caused by reduced levels of frataxin (FXN), an essential mitochondrial protein involved in the biosynthesis of iron-sulfur (Fe-S) clusters. Despite significant progress in recent years, to date, there are no good models to explore and test therapeutic approaches to stop or reverse the ganglionopathy and the sensory neuropathy associated to frataxin deficiency. Here, we report a new conditional mouse model with complete frataxin deletion in parvalbumin-positive cells that recapitulate the sensory ataxia and neuropathy associated to FA, albeit with a more rapid and severe course. Interestingly, although fully dysfunctional, proprioceptive neurons can survive for many weeks without frataxin. Furthermore, we demonstrate that post-symptomatic delivery of frataxin-expressing AAV allows for rapid and complete rescue of the sensory neuropathy associated with frataxin deficiency, thus establishing the pre-clinical proof of concept for the potential of gene therapy in treating FA neuropathy.

OTHER DISORDERS
- Addiction -
Vulnerability to ethanol sensitization predicts higher intake and motivation to self_administer ethanol: Proof of the incentive salience sensitization theory? (2019)
Vulnerability to ethanol sensitization predicts higher intake and motivation to self_administer ethanol: Proof of the incentive salience sensitization theory?
M del Carmen González_Marín, F Coune, M Naassila
INSERM UMR 1247—Research Group on Alcohol and Pharmacodependences (GRAP), Université de Picardie Jules Verne, Amiens, France
Published in "Addiction Biology" (2019-11-24)

Ethanol_induced behavioral sensitization (EIBS) is thought to play a key role in addiction. However, whether EIBS is linked to an increase in the motivation to self_administerethanol in an operant paradigm has never been demonstrated, and thus, the motivational sensitization theory (increase in drug wanting) has not been yet confirmed. We investigated using the operant ethanol self_administrationparadigm if the motivation to self_administerethanol (breakpoint) is increased in female mice prone to develop EIBS. Outbred female Swiss mice were treated once a day with 2.5_g ethanol per kilogram during 10 days and challenged with the same dose of ethanol 7 days later. EIBS_pronegroup was characterized by a significant increase in locomotion between the challenge day and day 1. When the difference was not significant, mice were considered as the “EIBS_resistant”group. Mice were then trained to nose poke for a 20% ethanol solution reinforcer under a FR1 and then a FR_2schedule of reinforcement. Motivation was assessed more directly with a progressive ratio schedule. Our results show that there is a positive correlation between EIBS and both the level of intake and motivation. Interestingly, acquisition of ethanol self_administrationwas faster in sensitized mice that also display a quick and long_lastingincrease in ethanol intake together with a lack of effect of alcohol challenge on c_Fosexpression restricted to the dorsolateral striatum. These results further support that EIBS vulnerability is crucial in the development of addictive behaviors and suggest a potential link with habit learning processes.

JOINTS
- Arthritis & Osteoarthritis -
Arthritis sensory and motor scale: predicting functional deficits from the clinical score in collagen-induced arthritis (2019)
Arthritis sensory and motor scale: predicting functional deficits from the clinical score in collagen-induced arthritis
AL Mausset-Bonnefont, M Cren, R Vicente, J Quentin
IRMB, University of Montpellier, INSERM, Montpellier, France
Published in "Arthritis Research & Therapy" (2019-12-04)

In the collagen-induced arthritis (CIA) mouse model, inflammation readouts are usually quantified using operator-dependent clinical scoring systems, and no systematic relationship with functional deficits has been detected. In this study, we extensively quantified sensory and motor deficits in CIA mice during natural disease progression and therapeutic treatment. Then, we used these data to build a scale to predict functional deficits on the basis of the classical clinical score.

MISCELLANEOUS
- Other pathologies -
Neuronal Gene Therapy for Friedreich Ataxia (2018)
Neuronal Gene Therapy for Friedreich Ataxia
F Piguet, C de Montigny, N Vaucamps, L Reutenauer, A Eisenmann, H Puccio
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France
Published in "Molecular Therapy" (2018-05-10)

Friedreich ataxia (FA) is a rare mitochondrial disease characterized by sensory and spinocerebellar ataxia, hypertrophic cardiomyopathy, and diabetes, for which there is no treatment. FA is caused by reduced levels of frataxin (FXN), an essential mitochondrial protein involved in the biosynthesis of iron-sulfur (Fe-S) clusters. Despite significant progress in recent years, to date, there are no good models to explore and test therapeutic approaches to stop or reverse the ganglionopathy and the sensory neuropathy associated to frataxin deficiency. Here, we report a new conditional mouse model with complete frataxin deletion in parvalbumin-positive cells that recapitulate the sensory ataxia and neuropathy associated to FA, albeit with a more rapid and severe course. Interestingly, although fully dysfunctional, proprioceptive neurons can survive for many weeks without frataxin. Furthermore, we demonstrate that post-symptomatic delivery of frataxin-expressing AAV allows for rapid and complete rescue of the sensory neuropathy associated with frataxin deficiency, thus establishing the pre-clinical proof of concept for the potential of gene therapy in treating FA neuropathy.


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IR Frame Dimensions LE 8815 (internal) 450 (W) x 450 (D) x 200 (H) mm
IR Frame Dimensions LE 8816 (internal) 250 (W) x 250 (D) x 200 (H) mm
Number of InfraRed Beams per Frame 32 (16 per axis)
InfraRed Photocells Spacing 25mm (LE8815), 13mm (LE8816)
Material Composition Aluminium, Polipropilene
Maximum number of stations 32 InfraRed Frames per computer (either SeDaCom or ActiTrack)
Power Requirements 110/220 V, 50/60 Hz
Certifications CE Compliant

Model:
LE8816
Infrared Actimeter
IR frame, 250 x 250 mm 16 x 16 IR beams Contact us

Related products:
LE8815
Infrared Actimeter
IR frame, 450 x 450 mm 16 x 16 IR beams Contact us

Accessories :
ACTITRACK
Acquisition software: ACTITRACK
Contact us
LE8820
Holeboard
Contact us
SEDACOM
SEDACOM:
SErial DAta COMmunication Software
Contact us
Print version

Bioseb - In Vivo Research Instruments
Phone worldwide : +33 442 344 360 - USA/Canada : (727) 521-1808
e-Mail : Worldwide: info@bioseb.com - USA/Canada: info-us@bioseb.com