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(Model: BIO-KWB-R - For rats)
A unique instrument that provides not only independent automated measurement of weight borne by each paw of a freely moving rodent (mouse or rat), like the Dynamic Weight Bearing, but also yields information curves on the force distribution over time, again for each paw independently.

A ground-breaking instrument for your research on analgesia, nociception and neuroscience, especially suited for work on Parkinson’s disease, Alzheimer’s disease, arthritis, brain or spinal cord injury.

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! NEW RESEARCH WORK ! A recent publication by Lakes EH, Allen KD in "Osteoarthritis Cartilage. " highlights the merits of using Bioseb's Kinetic Weight Bearing: Gait Analysis Methods for Rodent Models of Arthritic Disorders: Reviews and Recommendations EH Lakes, KD Allen - Osteoarthritis and Cartilage, 2016

Gait Analysis Methods for Rodent Models of Arthritic Disorders: Reviews and Recommendations EH Lakes, KD Allen - Osteoarthritis and Cartilage, 2016
Lakes EH, Allen KD
Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA; Institute for Cell & Tissue Science and Engineering, University of Florida, Gainesville, FL, USA.
Published in "Osteoarthritis Cartilage. " (2016-03-17)

Gait analysis is a useful tool to understand behavioral changes in preclinical arthritis models. While observational scoring and spatiotemporal gait parameters are the most widely performed gait analyses in rodents, commercially available systems can now provide quantitative assessments of spatiotemporal patterns. However, inconsistencies remain between testing platforms, and laboratories often select different gait pattern descriptors to report in the literature. Rodent gait can also be described through kinetic and kinematic analyses, but systems to analyze rodent kinetics and kinematics are typically custom made and often require sensitive, custom equipment. While the use of rodent gait analysis rapidly expands, it is important to remember that, while rodent gait analysis is a relatively modern behavioral assay, the study of quadrupedal gait is not new. Nearly all gait parameters are correlated, and a collection of gait parameters is needed to understand a compensatory gait pattern used by the animal. As such, a change in a single gait parameter is unlikely to tell the full biomechanical story; and to effectively use gait analysis, one must consider how multiple different parameters contribute to an altered gait pattern. The goal of this article is to review rodent gait analysis techniques and provide recommendations on how to use these technologies in rodent arthritis models, including discussions on the strengths and limitations of observational scoring, spatiotemporal, kinetic, and kinematic measures. Recognizing rodent gait analysis is an evolving tool, we also provide technical recommendations we hope will improve the utility of these analyses in the future.

Bioseb's Kinetic Weight Bearing: Rat inside the corridor
Rat inside the corridor
Another giant leap forward in incapacitance testing in rodents (mouse or rat): as in the flagship instrument Dynamic Weight Bearing (DWB), each individual animal paws weight is continuously and independently measured and tracked automatically. The Kinetic Weight Bearing Instrument additionally provides information on applied weight as well as the speed and acceleration of each paw as the animal moves toward an end point of the runway platform. This additional information provides data on coordination and gait comparison paw to paw and step to step!

KWB is an alternative method generating quantitative data on footprints and gait in spontaneously moving animals.

The unique and popular "sensor-mat" technology originally designed by Bioseb for the Dynamic Weight Bearing application has been refined and adapted to make kinetic analysis possible. This allows the weight borne by each individual paw to be tracked during a walking sequence in a corridor. The Kinetic Weight Bearing instrument combines the video of a freely walking rodent (mouse or rat) with the pressure applied by each paw in real time using an array of not less than 4000 or 6000 sensors depending on the corridor's length..

Gait analysis has been extensively used in phenotyping of CNS diseases such as cerebral ischemia, neurodegenerative diseases, Spinal Cord Injury models and some pain models like neurotrauma (Nerve Crush, SNI…) BIOSEB has added a major feature to existing gait analysis systems by including the measurement of the force applied by each individual paw to the floor the animal is walking upon.

Operating principle

The Kinetic Weight Bearing (KWB) Instrument offers automated parameter analysis for each paw of a rodent on Maximum Force (mN), Mass Velocity (N/s), and Maximum surface area (cm2). Additional Gait Parameters are also analyzed, speed, cadence, overlaps, and step patterns, are all compared and statistically processed. An automated analysis package is available for automatic analysis of a batch of experiments, saving time in analysis, and making the results more consistent, and less operator dependent.

The instrument combines the video of a freely moving rodent with the data supplied by the mat including up to 6000 sensors that cover the full length of a corridor at the end of which lies the animal's home cage. Gait analysis can be carried out, and can be applied in the study of diseases such as CNS ischemia, SCI, and Neurotrauma, for example.

Bioseb has demonstrated that the rising time to the maximum force of each animal step differs across different animal models. The KWB is able to compare the path of the animal's "Geometric Center of Gravity" with the actual "Weighted Center of Gravity", and show significant differences. Changes in weight distribution from left to right, front to back and contra-lateral compensation are easily measured, thus providing useful information for your research work on nociception and analgesia.

Bioseb's Kinetic Weight Bearing: Screenshot of Bioseb's new KWB software

Parameters measured

• Mean forces/weight ratio
• Peak force for each paw/animal weight
• Stride length /paw
• Swing duration /paw (s)
• Stance duration/ paw (s)
• Propulsion duration /paw (s)
• Step duration /paw (s)
• Paw speed
• Cadence
• BoS front rear
• Overlap left/right
• Scored prints/total
• Steps number for each paw
• Peak surface for each paw
• Animal speed
• Animal weight (g) (given by the operator)
• Ratio of any 2 parameters
Applications for your research

• Neurodegenerative diseases
• Parkinson’s disease
• Osteoarthritis
• Neuropathic pain
• Neurotrauma: Nerve Crush, SNI, etc.
• Cerebral ischemia
• Brain or spinal cord injury
• Ataxia
• Brain trauma
• Aging
• Muscles diseases
• Phenotyping

Key features

Bioseb's Kinetic Weight Bearing: Rat entering and exiting the corridor
Rat entering and exiting the corridor
Real time analysis and review process embedded in a single application programme interface
• Available for rats and for mice
• Measures gait parameters as well as max force/propulsion time applied for each step and each paw laid on the floor
• Correct trials detected (speed) and automatically split from A SINGLE video file
• Records Gravity Center Path and video barycenter
• Displays each run results and averaged results from homogeneous runs
Automatic software routine for paw identification from the first step to the end of the run
• Front wall easily removable for cleaning
• Adjustable corridor width
• Target zone fits animal home cage

Supplied with

• Rat cage
• Mouse cage
• Sensors mat x 2 + interfaces
• HD USB camera
• KWB Software licence: allows you to install the full software on 1 computer, and the software in "replay" mode on as many computers as needed!

Publications (Click on an article to show details and read the abstract)


Information published on this Web Site as well as services, product specifications, availability and prices are subject to change without notice. BIOSEB may also make improvements and/or changes in the products and/or the programs described in this Web Site at any time without notice.

BIOSEB has made reasonable efforts to verify that the information in this Web site was accurate when first published. Such information may contain errors or omissions, however, and it is subject to change without notice. Bioseb does not undertake to update this information to include any such changes or to correct errors or omissions. Bioseb assumes no responsibility for any use of the information in this Web site or for any infringement of patents or other rights of third parties that may result. Certain information may be country-specific and may not apply in all countries.

RAT: Overall dimensions 130 cm long x 50 cm width x 180 cm height, placed on the room floor
MICE: Overall dimensions 80 cm long x 40 cm width x 120 cm height, can be placed on a bench
Camera HD USB, 640x480
Sampling rate Sensors: 100 Hz
Camera: 30 Hz
Power supply Camera and sensors both powered through USB port
KWB Software licence Allows you to install the full software on 1 computer
and the software in "replay" mode on as many computers as needed!
PC Requirements Windows 7 - RAM 4 Gb - iCore 5 processor or later

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