! NEW RESEARCH WORK !
A recent publication
by SS Ballon Romero, YC Lee, LJ Fuh, HY Chung et al in "International Journal of Molecular Sciences" highlights the merits of using Bioseb's Electronic Von Frey 4
: Analgesic and Neuroprotective Effects of Electroacupuncture in a Dental Pulp Injury Model
16 years of experience in developing instrumentation for the Von-Frey test allows Bioseb to offer a new standard for mechanical sensitivity threshold measurment in rodents (mice and rats)
The Electronic Von Frey was designed to improve results quality and facilitate measurements compared to classical Von Frey filaments, which require several stimulations for each measurement, thus inducing stress in the animals. Our Electronic version determines the mechanical sensitivity in one single measurement.
The measured value is assessed with a resolution of 0.1 grams with a high-precision sensor which reduces the experimentation duration while improving repeatability between series. Results are shown on a large backlit display. The electronic instrument is not subjected to any temperature or hygrometry drift
The extended measurement range enables you to use the same instrument for different species (rats, mice, humans, etc.).
The latest version of the Electronic Von Frey includes a new, entirely redesigned stimulator handle for an easier and more balanced manipulation. Thanks to the increased comfort, operator fatigue and tension are notably reduced during experimental sessions involving large series of animals. A new, more accurate and rigid sensor is embedded in the handle to decrease sensitivity to the operator's movements.
Our Electronic Von Frey is built around a display unit connected to a stimulator handle. A foot switch is also provided for resetting the measurement, as well as a box of 10 interchangeable plastic tips.
The operator uses the handle to stimulate the target zone with the dedicated tips.
Stimulation under the rodent's paw:
Stimulation is usually applied on the rodent's hind paws. The paw's withdrawal following the mechanical stimulation is recorded as a response to the stimulus. The maximum force applied with the instrument, which corresponds to the necessary value for the paw's withdrawal, is saved into the system's memory and displayed on the electronic screen of the Electronic Von Frey unit with a resolution of 0.1 g. Different tips are used for rats (hard plastic) and mice (soft tips).
Specific application for human patients :
The instrument version dedicated to human subjects is supplied with a "patient button" allowing the patient under stimulation to freeze the measurement himself on the screen once the desired threshold (either sensitivity or pain) is reached.
The new Bioseb Electronic Von Frey offers numerous, exclusive improvements and new functionalities, among which:
A lighter stimulator
handle with the center of gravity placed more centrally for more precise movement and better control of the increase in force.
The new force sensor is both more accurate and rigid, improving reproducibility from a more homogenous stimulation. The variation linked to sudden movements is drastically reduced. The system is also easier to use on mice.
New spring tips for mouse stimulation: by absorbing impact forces, they increase accuracy on the 0-20 grams range.
As well as all the classical functionalities that made our Electronic Von Frey a "must have" for all your research projects in analgesia and nociception:
Large backlit LCD screen simultaneously displaying current and peak value
Statistical functions: average value and standard deviation are computed for each subject
Stand-alone instrument: internal memory allows the storing of up to 100 values, which may be transferred to a PC using our optional software
Dedicated BIO-CIS Software
Dedicated BIO-CIS Software
The multi-instrument BIO-CIS Software, by Bioseb, is compatible with all our mechanical allodynia / nociception measurement instruments and allows you to reduce inter-operator variability, which is an issue for these kinds of tests.
BIO-CIS can be used in two different ways with the Electronic Von Frey:
When the Electronic Von Frey is connected to the BIO-CIS software during stimulation, the software displays the real-time graph of applied force vs time in real-time. Additional features allows the definition of a theoretical ramp (force/time) with upper-lower limits to be followed and displayed during the measurement and curves of a group of measures can be reloaded and displayed simultaneously for a graphical overview. These options greatly help the operator to improve their skills with the instrument and reduce operator-introduced variability and is useful for generating impactful figures.
The Electronic Von Frey instrument embeds an internal memory allowing you to store up to 100 values measured during your experiments. You will then be able to connect the instrument to the BIO-CIS software and transfer all your results to an Excel spreadsheet.
Electronic Von Frey is designed to:
Measure the force applied on your subject during stimulation.
Measures are automatically displayed in grams (g)
You can also choose : Newton, Ibs and Oz
Measurement from 1 to 500g ! Perfect for any application !
Quickly determine the mechanical pain sensitivity threshold !
A few options for easier operations
A patient switch allows to freeze the displayed value when the threshold is reached
An RS232 interface allows to transfer the displayed value on to a computer
Our BIO-CIS software allows to write directly on EXCEL7 the value measured (PC with Windows 7 or higher) thus you avoid transcription errors, and get instant report
1 transportation case
1 foot switch for hand-free resetting of the test
10 disposable measurement tips of 0,5 mm diameter
1 spring tip for thresholds of 0-10 grams
Optional: "patient button" for use on human subjects.
New system! AlgoKit
A COMPLETE SOLUTION FOR ALL SITUATIONS
INVOLVING PAIN MEASUREMENT ON RODENTS
MULTIPLE PROBES, ONE CONTROL UNIT AND SOFTWARE APPLICATION
You may consider our new ALGOKIT package to expand the scope of your possibilities. In order to offer an answer to all your requests regarding different situations of pain measurement, Bioseb is proud to present an innovative, complete solution combining our Static Weight Bearing
, including its state-of-the art touchscreen, color console, with up to 3 sensors to be chosen among our Electronic Von Frey
, Rodent Pincher
and Small animal Algometer
, all connected to one unique Control Unit
Flexible instrument when a quantitative sensory testing (QST) is needed
Compatible with our BIO-CIS software to improve repeatability in nociceptive testing