! NEW RESEARCH WORK !
A recent publication
by S Bariselli, H Hšrnberg, C PrŽvost-SoliŽ, S Musardo, L Hatstatt-BurklŽ, P Scheiffele, C Bellone in "Nature Communications" highlights the merits of using Bioseb's Spatial place preference Test
: Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction
The Bioseb spatial place preference Test is an experimental chamber developed with the aim to optimise place preference and aversion studies in small laboratory animals, especially mice. The design of the box is fruit of a close collaboration with eminent Professor Dr. Rafael Maldonado and Dr. Olga Valverde from the Laboratory of Neuropharmacology in Barcelona (Spain).
The apparatus consists in a box with two equally sized compartments interconnected by a rectangular corridor. Originally, the compartments are differentiated by the motifs painted on the walls (dots or stripes) and the colour (different shade of grey tones, light or dark) and texture (smooth or rough) of the floor. The innovation brought by this box is the possibility to combine a new additional spatial dimension to allow the animal differentiate the different compartments in a more discriminative manner. Transparent walls are also used to minimize the time the animal spent in the corridor.
The introduction of these new discriminative elements allows:
• optimising the results obtained in the place preference and aversion paradigms (low variability in the response, reduced number of animals per group...)
• organizing the discriminative elements in a wide variety of configurations for studies evaluating spatial or contextual memory
• using the elements as discriminative cues associated with drug exposure in diverse other experimental designs.
The Bioseb spatial place preference box can be associated with the SMART video-tracking system for detection and analysis of animal position throughout the test.
• Parameters given by the associated video-tracking system
• Permance time in user-defined zone (SMART)
• Number of entries into user-defined zone (SMART)
• Distance travelled (SMART)
• And more... (SMART)
• Allows a multiple combination between the visual, tactile and spatial cues defining each compartment
• Optimize the differentiation between compartments
• Minimize initial place preference during pre-test phase
• Transparent walls to minimize time spent in the corridor
• Optimize subject detection using a video-tracking system
• Spatial memory
• Drug screening
• Neurodegenerative diseases connected to aging
• Compulsive disorders
• Addiction mechanisms
• Spatial Place Preference Box
• 2 reversible floors (one colored dark grey, the other light grey)
• 4 parallelepiped triangles (two colored in stripes, the other two in dots)
• 2 three sides pyramids (one colored in stripes, the other in dots)
• 2 sliding doors (one colored in stripes, the other in dots)
• Smart Video Tracking System