Site Metrics and Web Analytics by WebSTAT
Home > Catalog > Learning - Memory - Attention - Addiction
Product
Category
SPATIAL PLACE PREFERENCE TEST
(Model: LE895)
An experimental chamber developed with the aim to optimise place preference and aversion studies in small laboratory animals, especially mice, with a ground-breaking innovation: the possibility to combine a new additional spatial dimension to allow the animal differentiate the different compartments in a more discriminative manner.

- More information - - Documents - - Contact Bioseb -
Publications
Technical specifications
Other products / accessory  
Download PDF
This page is available in following languages:
! NEW RESEARCH WORK ! A recent publication by S Bariselli, H Hšrnberg, C PrŽvost-SoliŽ, S Musardo, L Hatstatt-BurklŽ, P Scheiffele, C Bellone in "Nature Communications" highlights the merits of using Bioseb's Spatial place preference Test: Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction

Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction
S Bariselli, H Hšrnberg, C PrŽvost-SoliŽ, S Musardo, L Hatstatt-BurklŽ, P Scheiffele, C Bellone
Department of Basic Neurosciences, University of Geneva, 1211, Geneva, Switzerland
Published in "Nature Communications" (2018-08-09)


Atypical habituation and aberrant exploration of novel stimuli have been related to the severity of autism spectrum disorders (ASDs), but the underlying neuronal circuits are unknown. Here we show that chemogenetic inhibition of dopamine (DA) neurons of the ventral tegmental area (VTA) attenuates exploration toward nonfamiliar conspecifics and interferes with the reinforcing properties of nonfamiliar conspecific interaction in mice. Exploration of nonfamiliar stimuli is associated with the insertion of GluA2-lacking AMPA receptors at excitatory synapses on VTA DA neurons. These synaptic adaptations persist upon repeated exposure to social stimuli and sustain conspecific interaction. Global or VTA DA neuron-specific loss of the ASD-associated synaptic adhesion molecule neuroligin 3 alters the behavioral response toward nonfamiliar conspecifics and the reinforcing properties of conspecific interaction. These behavioral deficits are accompanied by an aberrant expression of AMPA receptors and an occlusion of synaptic plasticity. Altogether, these findings link impaired exploration of nonfamiliar conspecifics to VTA DA neuron dysfunction in mice.

Presentation

The Bioseb spatial place preference Test is an experimental chamber developed with the aim to optimise place preference and aversion studies in small laboratory animals, especially mice. The design of the box is fruit of a close collaboration with eminent Professor Dr. Rafael Maldonado and Dr. Olga Valverde from the Laboratory of Neuropharmacology in Barcelona (Spain).


Operating principle

The apparatus consists in a box with two equally sized compartments interconnected by a rectangular corridor. Originally, the compartments are differentiated by the motifs painted on the walls (dots or stripes) and the colour (different shade of grey tones, light or dark) and texture (smooth or rough) of the floor. The innovation brought by this box is the possibility to combine a new additional spatial dimension to allow the animal differentiate the different compartments in a more discriminative manner. Transparent walls are also used to minimize the time the animal spent in the corridor.



The introduction of these new discriminative elements allows:
• optimising the results obtained in the place preference and aversion paradigms (low variability in the response, reduced number of animals per group...)
• organizing the discriminative elements in a wide variety of configurations for studies evaluating spatial or contextual memory
• using the elements as discriminative cues associated with drug exposure in diverse other experimental designs.


The Bioseb spatial place preference box can be associated with the SMART video-tracking system for detection and analysis of animal position throughout the test.


Parameters Measured

• Parameters given by the associated video-tracking system
• Permance time in user-defined zone (SMART)
• Number of entries into user-defined zone (SMART)
• Distance travelled (SMART)
• And more... (SMART)


Key features

• Allows a multiple combination between the visual, tactile and spatial cues defining each compartment
• Optimize the differentiation between compartments
• Minimize initial place preference during pre-test phase
• Transparent walls to minimize time spent in the corridor
• Optimize subject detection using a video-tracking system


Application domains

• Spatial memory
• Drug screening
• Neurodegenerative diseases connected to aging
• Compulsive disorders
• Phenotyping
• Addiction mechanisms
• Pain

Supplied with

• Spatial Place Preference Box
• 2 reversible floors (one colored dark grey, the other light grey)
• 4 parallelepiped triangles (two colored in stripes, the other two in dots)
• 2 three sides pyramids (one colored in stripes, the other in dots)
• 2 sliding doors (one colored in stripes, the other in dots)


Options

• Smart Video Tracking System


Publications (Click on an article to show details and read the abstract)


THE INFORMATION IN THIS WEB SITE AND IN LINKED PAGES AND DOCUMENTS IS PROVIDED "AS IS" AND DOES NOT CREATE ANY EXPRESS OR IMPLIED WARRANTY ABOUT BIOSEB OR ITS PRODUCTS OR SERVICES.

Information published on this Web Site as well as services, product specifications, availability and prices are subject to change without notice. BIOSEB may also make improvements and/or changes in the products and/or the programs described in this Web Site at any time without notice.

BIOSEB has made reasonable efforts to verify that the information in this Web site was accurate when first published. Such information may contain errors or omissions, however, and it is subject to change without notice. Bioseb does not undertake to update this information to include any such changes or to correct errors or omissions. Bioseb assumes no responsibility for any use of the information in this Web site or for any infringement of patents or other rights of third parties that may result. Certain information may be country-specific and may not apply in all countries.

Box Dimensions for MICE Total (ext.): 46 (w) x 27 (d) x 25 (h) cm
Compartments (int.): 20 (w) x 18 (d) x 25 (h) cm
Corridor (int.): 20 (w) x 7 (d) x 25 (h) cm
Box Dimensions for RATS Total (ext.): 88 (w) x 47 (d) x 45 (h) cm
Compartments (int.): 40 (w) x 34 (d) x 45 (h) cm
Corridor (int.): 25 (w) x 13 (d) x 45 (h) cm
Reversible Floor texture One side rough, one side smooth
Walls Width 6 mm
Material Composition Perspex
Position detection technique Weight transducers or video tracking
Automated weight transducer - Connection of several units to PC Neither PC interface nor PC card are required. One cable connects all units to the PC.
Automated weight transducer - Power Requirement 110/220 V, 50/60 Hz
Certifications CE Compliant

Model:
LE895
Spatial place preference Test
Contact us

Related products:
LE890
Place Preference Cage
for rats Contact us
LE891
Place Preference Cage
for mice Contact us
LE892
Place Preference Cage
for rats - with automatic position detection Contact us
LE893
Place Preference Cage
for mice - with automatic position detection Contact us

Accessories :
PPCWIN
PPCWIN software
Contact us
Print version

Bioseb - In Vivo Research Instruments
Phone worldwide : +33 442 344 360 - USA/Canada : (727) 521-1808
e-Mail : Worldwide: info@bioseb.com - USA/Canada: info-us@bioseb.com