! NEW RESEARCH WORK !
A recent publication
by A NIEWIADOMSKA-CIMICKA, F Doussau, JB Perot et al in "Molecular Neurodegeneration" highlights the merits of using Bioseb's Grip strength test
: SCA7 mice recapitulate CNS, PNS and retina pathologies and show a transcriptional signature of Purkinje cell dysfunction prevailing in SCA1 and SCA2 mice.
Grip Test: Mouse on the grid
BIOSEB's Grip Strength Test allows the study of neuromuscular functions by determining the maximal peak force developed by a rodent (rat or mouse) when the operator tries to pull it out of a specially designed grid or bar, which are available for both fore and hind limbs. The Grip Test has been documented in numerous literature
, and is included in the Functional Observational Battery (FOB) to screen for neurobehavioral toxicity. In this context, changes in grip strength peak values of rodents (rats or mice) are interpreted as evidence of motor neurotoxicity.
This force assessment is widely used in conjunction with the ROTAROD
motor coordination test, since a normally coordinated rodent will show a low score if its muscular strength is low.
The current Grip Strength Test apparatus is the third version based on Bioseb's methodology. The first version was developed in 1999, and Bioseb's Grip Strength Test now counts hundreds of users around the world !
You can click on following links to visit the webpage of researchers using our instrument
for their work on CNS (Central Nervous System) disorders, neuromuscular investigation and drug assessment:
• Bioseb's Grip Test Page of the Institut Clinique de la Souris (ICS), Strasbourg, France
• Bioseb's Grip Test Page of the MRC Harwell Internation Center for Mouse Genetics, Oxford, United Kingdom
• Grip Test Protocol by the European Mouse Phenotyping Resource of Standardised Screens (PDF file)
Bioseb’s Grip Strength Test for mice and rats is simple to operate
: the grip strength meter is positioned horizontally and the subjects are held by the tail and lowered towards the apparatus. The animals (rat or mouse) are allowed to grab the metal grid or triangular pull bar and are then pulled backwards in the horizontal plane. The force applied to the grid or to the bar just before it loses grip is recorded as the peak tension.
The measurement is accomplished using a highly accurate sensor
(same sensor for rats and mice) and an electronic device offering a sampling rate of 1000 Hz. This ensures that the maximum force is perfectly captured and displayed, even for short and low force peaks - this is especially useful when grip testing mice.
Measurements can be recorded and displayed in grams, newtons, or lbs
. The unit is directly selected on the keyboard. Data output is available through a RS232 port, a printer, or a graphic recorder. Individual measurements (up to 100) are stored in an internal memory, and can be downloaded after the experiment
Grids for Rat & Mouse, Bars for Mouse & Rat
The new Bioseb GRIP TEST Version 3+ offers unique features:
• A single instrument for mice and rats
, which may be used as a stand alone tool or connected to a printer or a PC
to measure from the front paws, back paws, or the 4 paws, in a mesh grid or in a bar version (see opposite illustration)
• Easy to operate
1. Hold the animal by the tail or the neck's skin.
2. Move the animal down until it grasps the grid/bar.
3. Pull the animal along the sensor axle until grip is released.
An embedded statistical computation has been included in the electronic device. This is a very useful feature that as been very well received and used by users of large numbers of tests. The display shows in real time the mean, standard deviation and variation coefficient from groups of animals. This feature allows also to cancel any grip strength test not correctly performed.
The optional Bioseb’s Bio-CIS software sends datas acquired via the Grip Test into a MS Excel sheet using the RS232 port. Easy to set up, this soft interface uses the full power of MS EXCEL functions, to let you create statistical tables and graphics.
Grip Test: Screenshots
• Embedded statistics module
: a new development by Bioseb allows direct reading of the average value, standard deviation and variability for several subjects groups and up to 100 animals. This feature allows also to cancel any grip strength test not correctly performed.
• Very fast sampling rate of 1000Hz
, to secure the repeatability in the “peak” force capture and measurement
• Highly reliable sensors
, 0.1% of full scale and a fine resolution (resolution is user-settable as low as 0,1g)
• Internal memory
for measured data, up to 100 values
can be stored manually, to be edited or downloaded later
• Data is stored in memory as a table with time/measured force
• Built-in RS 232 port allowing transfer of data to a PC or a printer
• Optional Bioseb Bio-CIS Software
allowing user to send measured values directly into a Microsoft Excel spreadsheet
1 stand and counter weight, 1 grip accessory (to be chosen among the available models described above), power supply adaptor (100-240 V), user manual and tutorial.
Special model upon request
Higher capacity (marmoset), double sensor, Meyer's method (double gauge, front to front). Please enquire
Domains of application
• Neuromuscular diseases
• Drug screening
• Parkinson disease
• Huntington disease