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SHUTTLE BOXES
(Model: LE916 - for rats)
Ideal environment to carry out conditioned reflexes
(Active and Passive Avoidance)
in learning and memory studies


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  • INSTITUT CLINIQUE DE LA SOURIS ILLKIRCH, France
  • BIOCODEX Compiègne, France
  • UCB BRAIN L'ALLEUD, France
  • SERVIER CROISSY SUR SEINE, France
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! NEW RESEARCH WORK ! A recent publication by Bentefour Y, Bennis M, Garcia R, M'hamed SB in "Psychopharmacology (Berl). " highlights the merits of using Bioseb's Shuttle Boxes: Effects of paroxetine on PTSD-like symptoms in mice

Effects of paroxetine on PTSD-like symptoms in mice
Bentefour Y, Bennis M, Garcia R, M'hamed SB
Cadi Ayyad Université, Marrakech, Maroco
Published in "Psychopharmacology (Berl). " (2015-01-15)


RATIONALE:
After exposure to a severe traumatic event, avoidance, fear sensitization, and increased anxiety are among features that can persist over time in people developing posttraumatic stress disorder (PTSD). Basic research on treatment interfering with these symptoms can provide insights to improve PTSD treatment.

OBJECTIVES:
The purposes of the present study were to induce these behavioral changes in mice and examine whether paroxetine would interfere with their expression.

METHODS:
Mice were submitted to avoidance training with a low (0.4 mA) or high (1.5 mA) foot-shock intensity, as mild and severe stressors, respectively, and posttraining avoidance was evaluated 1 and 12 days later. Fear sensitization, measured as increased freezing to a neutral tone, and enhanced contextual fear, measured as increased freezing to a conditioned context (wherein all mice received a 0.4-mA foot-shock), were assessed during this time window. An elevated plus maze test was also used to assess mouse anxiety-like behavior.

RESULTS:
Persistent avoidance, persistent fear sensitization, and long-term enhancement of contextual fear and increased anxiety-like behavior were established only in mice that received the 1.5-mA foot-shock during avoidance training. Paroxetine (at 8 mg/kg/day), injected from day 5 to day 11 after avoidance training, suppressed all of these behavioral changes.

CONCLUSIONS:
These data provide additional evidence for the role of paroxetine against expression of PTSD-like behaviors in mice.

Presentation

BIOSEB Shuttle Boxes LE916 (Rats) and LE918 (Mice) provide the ideal environment to carry out conditioned reflexes (Active and Passive Avoidance) in learning and memory studies.


Operating principle

Basically, the BIOSEB Shuttle box (LE916-918) consists in two equally sized compartments with two independent grid floors.
A frontal door, in addition to the top ones, allows an easy access inside the box. The cage contains a general sound generator and a visual stimulus (light) for each compartment.

The Animal is detected by two Weight Transducers located above the static grids, avoiding the problems inherent to photoelectrical or grid tilting systems (high speeds of displacements in mice, tail detection in rats).

BIOSEB Shuttle box is thought to be easily set up and dismantled. Therefore, reconverting it to traditional Passive Box is quite straightforward by adding a sliding door (LE916D for mice or LE918D for rats). Furthermore, it is possible to set up different wall shapes or colours in order to further condition the subject of study either visually or spatially.

The shuttle boxes can be controlled by Programmer LE2708 or SHUTAVOID software. SEDACOM software can be used to transfer data from the programmer to a PC through a RS232 port.
It is not necessary the interface neither the use of board installed into the PC. The link is carried out by one only cable from one Box to the other. The first Box is connected to PC or Laptop by the port RS 232 or USB. The second option is suitable for controlling a number of boxes simultaneously.

PC connection scheme
PC connection scheme



Parameters Measured

• Latency to entrance into the black compartment (passive avoidance)
• Number and latency of conditioned responses (active avoidance)
• Number and latency of unconditioned responses (active avoidance)
• Number and latency of null responses (active avoidance)
• Number and latency of none responses (active avoidance)
• Number of compartment changes during the intertrial intervals (active avoidance)
• Latency mean and accumulated responses sorted by interval of time


Key features

• Highly sensitive weight transducer system for accurate animal detection
• Easy to set up different wall shapes and colours
• Optional guillotine door
• Compartments with independent grid floor
• Frontal and top doors for an easy access inside the box
• Up to 8 Active Boxes can be controlled at once from a PC
• Neither PC interface nor PC cards are required
• Safety System which guarantees that the shock intensity received by the animal is always the same value independently of the grid bars treaded


Publications (Click on an article to show details and read the abstract)


THE INFORMATION IN THIS WEB SITE AND IN LINKED PAGES AND DOCUMENTS IS PROVIDED "AS IS" AND DOES NOT CREATE ANY EXPRESS OR IMPLIED WARRANTY ABOUT BIOSEB OR ITS PRODUCTS OR SERVICES.

Information published on this Web Site as well as services, product specifications, availability and prices are subject to change without notice. BIOSEB may also make improvements and/or changes in the products and/or the programs described in this Web Site at any time without notice.

BIOSEB has made reasonable efforts to verify that the information in this Web site was accurate when first published. Such information may contain errors or omissions, however, and it is subject to change without notice. Bioseb does not undertake to update this information to include any such changes or to correct errors or omissions. Bioseb assumes no responsibility for any use of the information in this Web site or for any infringement of patents or other rights of third parties that may result. Certain information may be country-specific and may not apply in all countries.

LE916 Rat Cage Dimensions 510 (W) x 250 (D) x 240 (H) mm internal
580 x 360 x 305 mm external
LE918 Mice Cage Dimensions 590 (W) x 190 (D) x 240 (H) mm internal
580 x 360 x 305 mm external
Minimum weight detected 10 grams (Mouse Box) - 40 grams (Rat Box)
Material Composition Methacrylate, aluminium, stainless steel
Connection of several units to PC Neither PC interface nor PC card are required
One cable connects all units to the PC
Maximum number of stations (with SHUTAVOID) 8 stations connected to a PC
Certifications CE Compliant
Power Supply 110V/220V, 50/60Hz

Model:
LE916
Shuttle Boxes
for rats Contact us

Related products:
LE870
Passive avoidance
for rats Contact us
LE872
Passive avoidance
for mice Contact us
LE918
Shuttle Boxes
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