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NON INVASIVE PRESSURE MEASUREMENT
(Model: LE5001 - Basic Unit for indirect blood pressure)
Easy and reliable technique to measure systemic blood pressure and cardiovascular parameters in rodents (rats and mice) without any invasive catheterisation

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  • Ecole veterinaire, Nantes, France
  • Université Reims UFR Pharmacie, Reims, France
  • INSERM Hopital de Bicetre, Paris, France
  • Université d'Anvers, Anvers, Belgium
  • INSERM Université Strasbourg, Strasbourg, France
  • Université Marseille, Marseille, France
  • Université Nimes, Nimes, France
  • Université de Montpellier Physiologie, Montpellier, France
  • CNRS, Faculté de médecine d'Angers, Angers, France
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! NEW RESEARCH WORK ! A recent publication by G Aubertin, M Weiss, F Traversi, D Benameur et al in "International Journal of Obesity" highlights the merits of using Bioseb's Non Invasive Pressure Measurement: Effects of imidazoline-like drugs on liver and adipose tissues, and their role in preventing obesity and associated cardio-metabolic disorders

Effects of imidazoline-like drugs on liver and adipose tissues, and their role in preventing obesity and associated cardio-metabolic disorders
G Aubertin, M Weiss, F Traversi, D Benameur et al
Laboratoire de Pharmacologie et Toxicologie NeuroCardiovasculaire (LPTNC) - EA7296, FacultŽ de MŽdecine, FŽdŽration de MŽdecine Translationnelle, UniversitŽ de Strasbourg, Strasbourg, France
Published in "International Journal of Obesity" (2019-03-29)


We previously observed that selective agonists of the sympatho-inhibitory I1 imidazoline receptors (LNP ligands) have favorable effects on several cardiovascular and metabolic disorders defining the metabolic syndrome, including body weight. The objectives of this study were to explore the effects of LNPs on adiposity and the mechanisms involved, and to evaluate their impact on metabolic homeostasis.
Presentation

The pulse signal level (heart rate) is permanently monitored on the LCD display while an internal pressure transducer is constantly measuring the current pressure applied on the cuff. Measurement process involves several steps which are performed automatically; systolic and diastolic blood pressure and calculated mean blood pressure are visualized in real-time in the digital display of the control unit. With regards to the systolic pressure, it can be achieved either once the heart pulse disappears or else when the first pulse reappears (user selectable) after the occlusion process.

The system allows a sequential measurement of 6 to 12 animals without having to change pulse transducers and tail cuffs (Automatic Heater & Scanner option). A built-in air pump ensures automated cuff inflation/deflation at constant and even rate. In order to avoid deterioration of the animal’s tail after submitting animals to unnecessary high occlusion pressures, the automated deflation is carried out for each animal and separately, once their own systolic value is reached. Real values (without linear regression calculation) are thus achieved while remaining easily traceable: visualization of the signal through the USB software interface NIBPchart. All units can be indistinctly used for rats, mice or dogs, using specific pulse transducers & cuff.

The requirement of a warm environment for the animals is critical for accurate blood pressure measurements. To provide adequate conditions for NIBP measurement, the system can be use in association to a warming chamber which provides a comfortable and heated environment necessary to produce peripheral vasodilatation and isolate the animal from external noise.

Operating principles

Non Invasive Blood Pressure: Transducer and cuff
Transducer and cuffs
The N.I.B.P. method in animals is based on the same sphygmomanometric technique used for measuring arterial pressure in humans. Like its counterpart for human use, this kit is equipped with a cuff to occlude blood flow as well as a transducer to follow pulse evolution throughout the measuring process.

Systolic pressure
The cuff is inflated until the pulse signal disappears due to the blocking of the caudal artery. Once the signal disappearance has been detected, the cuff deflates automatically. Systolic pressure corresponds then to the pressure value on the cuff when the pulse begins to reappear.

Diastolic pressure
The cuff continues to deflate progressively until the pulse signal recovers its initial value. The pressure reading at this moment corresponds to diastolic pressure. Our system estimates that the pulse has been completely recovered when the signal has reached 80% of the pulse baseline value (and not 80% of the systolic value)

Mean Blood Pressure (MBP)
Once the systolic and diastolic pressure values have been obtained, the system automatically calculates the mean pressure while the cuff is completely deflated for the next evaluation. This value can be calculated using the following formula: MP = DP + 0.33 (SP - DP)

Parameters measured

• Systolic blood pressure
• Diastolic blood pressure
• Mean blood pressure
• Heart rate

Key features

• Total reliability to realize consecutive measurements on the same animal
• Automated deflation driven separately for each animal (minimize tail lesions)
• Analogic Signal output for recording cuff pressure and pulse signals in a PC
• Automated cuff inflation/deflation at a very constant rate
• The same system can be used for Rat / Dog / Mice
• Real values provided (without any linear regression calculation)
• Easily traceable data (using NIBPchart software)
• Parameters evaluated can be visualized on-line on the digital display

Non Invasive Pressure Measurement by Bioseb: LE56506 Scanner and Heater
LE56506 Scanner and Heater
Domains of application

• Cardiovascular studies - Non-Invasive Blood Pressure
• Drug screening
• Phenotyping
• Hypertension/hypotension studies
• Obesity
• Kidney disease studies
• Addison’s disease studies
• Sepsis
• Toxin reaction studies

Options

Heating tunnels (mono or multianimals)
• Card and software for visualising, on PC (through an USB port), the pressure and heart frequency curve. The software allows monitoring, stocking and printing of the curves. It is essential for experiments on mice.

See also:
Rodents restrainers
Cuffs and detectors

Publications (Click on an article to show details and read the abstract)

METABOLISM
- Adioposity -
Effects of imidazoline-like drugs on liver and adipose tissues, and their role in preventing obesity and associated cardio-metabolic disorders (2019)
Effects of imidazoline-like drugs on liver and adipose tissues, and their role in preventing obesity and associated cardio-metabolic disorders
G Aubertin, M Weiss, F Traversi, D Benameur et al
Laboratoire de Pharmacologie et Toxicologie NeuroCardiovasculaire (LPTNC) - EA7296, FacultŽ de MŽdecine, FŽdŽration de MŽdecine Translationnelle, UniversitŽ de Strasbourg, Strasbourg, France
Published in "International Journal of Obesity" (2019-03-29)

We previously observed that selective agonists of the sympatho-inhibitory I1 imidazoline receptors (LNP ligands) have favorable effects on several cardiovascular and metabolic disorders defining the metabolic syndrome, including body weight. The objectives of this study were to explore the effects of LNPs on adiposity and the mechanisms involved, and to evaluate their impact on metabolic homeostasis.


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LE5001 Basic unit for NIBP with RS232 comms. Port. Cuff, transducer and Software options have to be ordered separately.
LE5002 Standard Unit for NIBP with Memory and RS232 comms. port. Cuff, transducer and Software options have to be ordered separately.
LE5007 Complete Unit for N.I.B.P. with Scheduled data acquisition (up to 12 animals) Memory and RS232 comms. port. Cuff, transducer and Software options have to be ordered separately.
Power Supply 220V/110V, 50/60Hz
Certifications CE Compliant

Model:
LE5001
Non Invasive Pressure Measurement
Basic Unit for indirect blood pressure Contact us

Related products:
LE5002
Non Invasive Pressure Measurement
Standard Unit for indirect blood pressure Contact us
LE5007
Non Invasive Pressure Measurement
Programmable Unit for indirect blood pressure for up to 12 animals Contact us

Accessories :
LE5160M
Cuffs and pulse transducers for LE 500X indirect blood pressure meters
For mice and rats up to 150 grams Contact us
LE56506
Warming chambers for pressure measurement
For six rats or six mice Contact us
LE5610
Warming chambers for pressure measurement
For 1 rat or 1 mouse Contact us
LE5160MM
Cuffs and pulse transducers for LE 500X indirect blood pressure meters
For mice Contact us
LE5160R
Cuffs and pulse transducers for LE 500X indirect blood pressure meters
For rats Contact us
LE5015
Cuffs and pulse transducers for LE 500X indirect blood pressure meters
For dog Contact us
LE5012
Cuffs and pulse transducers for LE 500X indirect blood pressure meters
For dog Contact us
LE5016
Rodents Restrainers
Mice up to 35 g (90 x 30 mm) Contact us
LE5018
Rodents Restrainers
Mice up to 50 g (100 x 34 mm) Contact us
LE5020
Rodents Restrainers
Rats from 80 up to 200 g (150 x 44 mm) Contact us
LE5022
Rodents Restrainers
Rats from 180 up to 320 g (180 x 54 mm) Contact us
LE5024
Rodents Restrainers
Rats from 300 to 440 g (200 x 64 mm) Contact us
LE5025
Rodents Restrainers
Rats from 440 up to 550 g (225 x 74 mm) Contact us
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