- BIOSEB NEWS -
MAY 2015

NEUPSIG MEETING &
FRENCH NEUROSCIENCE 2015

IN THIS ISSUE:

- NEUPSIG & SdN 2015  -

Visit Bioseb
in Nice & Montpellier
on booth nº 3 & 18

- INNOVATION -

Kinetic Weight Bearing:
Automated analyzis
of gait parameters

Activity Wheels:
Anxiety-like
and sex-dependent
behaviors

Dynamic Weight bearing
New applications
 
- CONTACT -

For any question or additional information,
please contact us :
info@bioseb.com
SPECIAL ISSUE - DOUBLE MEETING - NEUPSIG NICE / SfN MONTPELLIER, FRANCE
NEUPSIG AND FRENCH NEUROSCIENCE 2015:
DOUBLE OPPORTUNITY TO GET A LIVE DEMO OF OUR LATEST INNOVATIONS

BIOSEB inaugurates the congress season with two major events in France: the Neuropathic pain congress NEUPSIG in Nice, France from May the 14th until the 17th, and the French Neuroscience Meeting from May the 19th until the 22nd in Montpellier.


Among our extended range of automated instruments for behavioral measurement, following innovative systems will especially be on display:

• Our Kinetic Weight Bearing for spinal cord injuries models and studies on arthritis.
• Our Activ-wheel's new automated design, useful for studying depression-like models and sex-dependent mechanisms.
• Our Dynamic Weight Bearing, an instrument quoted in numerous publications for rodents' phenotyping and spinal cord studies.

Read below how these instruments will boost your research work, and drop by for a demonstration on booth nº 3 In NEUPSIG and booth n°18 in FRENCH NEUROSCIENCES.

Our technical and sales team will be very pleased to demonstrate the whole range of exclusive behavioral instruments developed in 2014 and 2015.

B. Hancy, Operations manager

KINETIC WEIGHT BEARING: INSTRUMENTED CROSSING CORRIDOR
Measures propulsive forces using gait analyzis system

Bioseb's Kinetic Weight Bearing
KWB Overview with instrumented corridor

Kinetic Weight Bearing: Screenshot of the gait curves
Screenshot of the gait curves
The Kinetic Weight Bearing (KWB) is available for rats and for mice. Featuring up to 6000 pressure sensors over the whole corridor, the KWB is able to automatically analyze the weight borne on each paw while the animal crosses the corridor to get back to its home cage. The innovation lies within its unique technology: the floor is made of 3 sensor-mats that directly provide the true peak force in grams.

Complementary synchronized gait parameters are also computed: speed, cadence, number of steps, boS, overlap stride, swing, stance, propulsion duration....

KWB is a powerful tool to study traumatic spinal cord injuries and is widely used for:
• Contusions or transection models studying neuroprotective and neuroregenerative approaches
• Decompression models
• Arthritis models generated by Hemisection or MIA injection.


ACTIVITY WHEELS: ANXIETY-LIKE BEHAVIORS AND SEX-DEPENDENT MECHANISMS
New activity wheel design
Bioseb's new activity wheel design

Among all the possible applications that are offered by the Bioseb ACTIVWHEEL, two of them are of a particular interest:

1. Various pharmacological treatments need to be tested for their potential effect on spontaneous activity. Hormonal substitute treatments effect can be tested on mice or rat. Our Active-wheels not only provide an accurate assessment of the work expended by the animal, but also additional information regarding troubles of circadian rhythms, thanks to their very sensitive wheel access detection (26° both direction).

2. Voluntary wheel running has been used in various publications to study the effect of voluntary exercise on anxiety-related behavior. Depending on species and strength, links between exercise and reduction of anxiety measured through various paradigms have been observed (EPM, B&W Open Field : cf. S. Alisha Epps et al, Garrett el al, Duman Ch et al, etc). Most of those results have been achieved using Activity wheels for several weeks.

Thanks to a reliable USB communication protocol, Bioseb's Activwheel is ideal for long-term studies and the acquisition can be paused or started anytime - for instance when you need to change bedding during an acquisition running over several weeks.



DYNAMIC WEIGHT BEARING : UPDATE ON RESEARCH APPLICATIONS
Dynamic Weight Bearing, by Bioseb
Close-up view of our DWB System
Bioseb is the world leader in the weight bearing technology!

Here is the most recent feedback regarding the use of the Dynamic Weight Bearing (DWB) as a powerful and non-invasive method to phenotype variety of models, ranging from bone cancer to traumatic spinal cord injuries.

As an addition to all the pain models already tested and published with the DWB, our customer have focused on PELVIC/ABDOMINAL pain with potential applications such as endometriosis diseases. The deleterious effect of joint prosthesis or decompression sickness is another potential application currently under evaluation with the DWB.

Highlighted topics in recent publications are:
• Nonevoked Inflammatory Hyperalgesia in Mice (Griffioen, Mari A et al)
• Peripherical nerve injury in early life (Rebecca McKelvey et al)
• Orthopedic surgery and bone fracture pain (Majuta, Lisa A et al)
• A multi-target approach for pain treatment (Malek, Natalia et al)
• Sodium Channels and Pain AM (Habib et al)