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The Contextual Kits for T2CT have been designed to enhance thermal place preference studies...
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The BIOSEB Spontaneous Activity Wheel is an easy way to quantify rodent voluntary activity in...
The uncomplicated way to monitor rodent activity over several days from their home cage...
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An operator independent test to study pain thresholds in rodents (mouse and rat) by assessing...
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A brand new innovative setup for the automation of the Novel Object Recognition Test : 3D-camera...
Open-field test - ARENA ONLY - used to evaluate of animal's basal activity and its evolution for...
An entirely modular experimental enclosure designed to conduct operant conditioning procedures...
A standard experimental chamber for automated or manual assessment of conditioned place...
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The ETH-401 is a bridge amplifier for various transducers that provides four channels of...
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The ETH-256 is a 2 channels high performance, general-purpose life science research amplifier,...
Discover BIO-FOODIS, the next generation solution for understanding animal feeding behavior with...
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Bioseb's version 5 of the Tail Suspension Test system, based on both strain sensors and video acquisition, is the only fully automatic solution in the world for running a simple and objective despair test on mice. It is a fast, painless, and reliable way for testing psychotropic effects from stimulant doses of drugs such as anti-depressants and sedatives. This classic and painless research test for anxiety and depression is now offered with a new, powerful and modern software, in a wireless, bluetooth-based version.
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Presentation
The tail-suspension test was developed as an alternative to the Porsolt Forced Swimming test, and is based on a similar concept. Mice, suspended by their tail using a piece of tape (a painless method), innately attempt to escape from this adversive situation. However, following failed attempts to escape, they experience a kind of despair and become immobile. The magnitude of immobility is considered to be correlated with the depressive-like state of the subjects and is significantly decreased by antidepressants. The Tail Suspension Test was described in the 80's by Steru & al. and allows for fast evaluation of drugs' (anti-depressants, sedatives) psychotropic effects, making it a classic and painless research test for anxiety and depression.
BIOSEB' Tail Suspension Test system is the only full automatic test in the world!. It is based on the original “ITEMATIC-TST” described by Steru in 1987, it uses both strain gauges and video backup recording, and does not induce any pain in the animal: the mouse’s tail is simply stuck to the sensor using a piece of tape.
The original ITEMATIC design has been modified, adapted and improved for the Porsolt and Partners Pharmacology Co in the 2000. It can hold 3 mice in three separate compartments and features adjustable floor height and anti climbing plates for C57 strain mice.
The Bioseb Tail Suspension Test instrument offers unique features such as the randomization process of the animals, the measurement of up to 6 animals in the same run, the direct computations of the 'Immobility', the 'Energy' and the 'Power in Motion'. Settings are available to adjust the definitions to the user's protocol. The energy value is a unique way to differentiate between passive swinging and active struggling. The power in motion is an additional discriminating calculation that gives an indication of the strength of the mice.
How does it work?

The measuring principle is based on the quantity of movements that a mouse trying to escape from its suspension can generate. During the Tail Suspension Test, the movements of the mice are analyzed in terms of activity (active/non active), energy and power developed over time. As human observation is time consuming and tedious, Bioseb's Tail Suspension Test (TST) automates the entire experiment.
The operator prepares his pieces of tape to suspend mice and the home cages with mice to be tested. When the whole experiment has been setup in the software and the list of animals randomized, the operator suspends each single mouse according to the randomization shown on the screen. Each channel is started individually by pressing a specific key on the computer so that each mouse is suspended the same amount of time (something impossible with a system based solely on video).
When the run is finished, mice are removed and the operator is prompted to suspend the next batch of mice. After the experiment, the whole batch can be analyzed and statistics on averages minimums, maximums and standard deviations are computed in seconds as is individual performance. Data is also presented within minutes for both the groups and individual animals (mice).
The TST-SOFT generates graphics that can be exported as a bmp image for further presentations.
Supplied with
• One or two sets of three cages together with power supplies and USB cables as needed.
• 1 software license (USB dongle with product ID tag)
• Optional HD USB camera and its tripod and USB cable
Data sheet
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[title] => Rosa multiflora fructus and its active compound ellagic acid improve depressive-like behaviors in mice via monoamine oxidase inhibition
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[title] => Na V 1-2 haploinsufficiency in Scn2a knock-out mice causes an autistic-like phenotype attenuated with age
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[title] => Metformin promotes anxiolytic and antidepressant-like responses in insulin-resistant mice by decreasing circulating branched-chain amino acids
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[title] => GLS1 mutant mice display moderate alterations of hippocampal glutamatergic neurotransmission associated with specific adaptive behavioral changes
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[title] => Depression_like symptoms of withdrawal in a genetic mouse model of binge methamphetamine intake
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[title] => Standardized Citrus unshiu peel extract ameliorates dexamethasone-induced neurotoxicity and depressive-like behaviors in mice
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[title] => Treatment with HC-070- a potent inhibitor of TRPC4 and TRPC5- leads to anxiolytic and antidepressant effects in mice
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[title] => Impaired microglia fractalkine signaling affects stress reaction and coping style in mice
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[image_presente] =>
[date] => 2017-07-23 00:00:00
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[title] => S 47445 Produces Antidepressant- and Anxiolytic Like Effects through Neurogenesis Dependent and Independent Mechanisms
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[image_presente] =>
[date] => 2017-07-19 00:00:00
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[title] => FGF-2 deficiency causes dysregulation of Arhgef6 and downstream targets in the cerebral cortex accompanied by altered neurite outgrowth and dendritic spine morphology
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[url] => https://bioseb.com/en/news/probable-involvement-of-p11-with-interferon-alpha-induced-depression-n819
[title] => Probable involvement of p11 with interferon alpha induced depression
[paragraph_crop] => Probable involvement of p11 with interferon alpha induced depression
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[date] => 2016-01-29 00:00:00
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[title] => Enriched environment decreases microglia and brain macrophages inflammatory phenotypes through adiponectin-dependent mechanisms- Relevance to depressive-like behavior
[paragraph_crop] => Enriched environment decreases microglia and brain macrophages inflammatory phenotypes through [...]
[image_presente] =>
[date] => 2015-07-22 00:00:00
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[url] => https://bioseb.com/en/news/synthesis-and-evaluation-of-new-1-5-diaryl-3-4--methyl-sulfonyl-phenyl-4-5-dihydro-1h-pyrazole-derivatives-as-potential-antidepressant-agents-n644
[title] => Synthesis and Evaluation of New 1-5-Diaryl-3-[4--methyl-sulfonyl-phenyl]-4-5-dihydro-1H-pyrazole Derivatives as Potential Antidepressant Agents
[paragraph_crop] => Synthesis and Evaluation of New [...]
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[url] => https://bioseb.com/en/news/antinociceptive-and-antidepressant-like-action-of-endomorphin-2-analogs-with-proline-surrogates-in-position-2-n641
[title] => Antinociceptive and antidepressant-like action of endomorphin-2 analogs with proline surrogates in position 2
[paragraph_crop] => Antinociceptive and antidepressant-like action of endomorphin-2 analogs with proline [...]
[image_presente] =>
[date] => 2014-09-01 00:00:00
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[url] => https://bioseb.com/en/news/altered-skeletal-muscle-mitochondrial-biogenesis-but-improved-endurance-capacity-in-trained-opa1-deficient-mice-n516
[title] => Altered skeletal muscle mitochondrial biogenesis but improved endurance capacity in trained OPA1-deficient mice
[paragraph_crop] => Altered skeletal muscle mitochondrial biogenesis but improved endurance capacity in trained [...]
[image_presente] =>
[date] => 2013-12-01 00:00:00
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[title] => Genetics
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[514] => Array
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[id] => 514
[url] => https://bioseb.com/en/news/early-postnatal-motor-experience-shapes-the-motor-properties-of-c57bl-and-6j-adult-mice--n514
[title] => Early postnatal motor experience shapes the motor properties of C57BL and 6J adult mice-
[paragraph_crop] => Early postnatal motor experience shapes the motor properties of C57BL/6J adult mice.
[image_presente] =>
[date] => 2013-11-30 00:00:00
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[title] => Miscellaneous research domains
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[id] => 513
[url] => https://bioseb.com/en/news/antidepressant-and-anxiolytic-potential-of-the-multimodal-antidepressant-vortioxetine--lu-aa21004--assessed-by-behavioural-and-neurogenesis-outcomes-in-mice-n513
[title] => Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine -Lu AA21004- assessed by behavioural and neurogenesis outcomes in mice
[paragraph_crop] => Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu [...]
[image_presente] =>
[date] => 2013-10-30 00:00:00
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[title] => Depression
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[url] => https://bioseb.com/en/news/neurochemical-changes-in-the-mouse-hippocampus-underlying-the-antidepressant-effect-of-genetic-deletion-of-p2x7-receptors-n515
[title] => Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors
[paragraph_crop] => Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic [...]
[image_presente] =>
[date] => 2013-06-21 00:00:00
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[title] => Depression
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[title] => Mood disorders
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[title] => Publications
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[517] => Array
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[id] => 517
[url] => https://bioseb.com/en/news/the-absence-of-p2x7-receptors--p2rx7--on-non-haematopoietic-cells-leads-to-selective-alteration-in-mood-related-behaviour-with-dysregulated-gene-expression-and-stress-reactivity-in-mice--n517
[title] => The absence of P2X7 receptors -P2rx7- on non-haematopoietic cells leads to selective alteration in mood-related behaviour with dysregulated gene expression and stress reactivity in mice-
[paragraph_crop] => The absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective [...]
[image_presente] =>
[date] => 2013-02-01 00:00:00
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[title] => Genetics
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[title] => Stress
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[id] => 434
[url] => https://bioseb.com/en/news/both-chronic-treatments-by-epothilone-d-and-fluoxetine-increase-the-short-term-memory-and-differentially-alter-the-mood-status-of-stop-and-map6-ko-mice-n434
[title] => Both chronic treatments by epothilone D and fluoxetine increase the short-term memory and differentially alter the mood status of STOP and MAP6 KO mice
[paragraph_crop] => Both chronic treatments by epothilone D and fluoxetine increase the short-term memory and [...]
[image_presente] =>
[date] => 2012-10-25 00:00:00
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[452] => Array
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[id] => 452
[url] => https://bioseb.com/en/news/anti-depressant-like-effect-of-vitexin-in-balb-and-c-mice-and-evidence-for-the-involvement-of-monoaminergic-mechanisms-n452
[title] => Anti-depressant-like effect of vitexin in BALB and c mice and evidence for the involvement of monoaminergic mechanisms
[paragraph_crop] => Anti-depressant-like effect of vitexin in BALB/c mice and evidence for the involvement of [...]
[image_presente] =>
[date] => 2012-10-22 00:00:00
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[id] => 430
[url] => https://bioseb.com/en/news/differential-effects-of-early-environmental-enrichment-on-emotionality-related-behaviours-in-huntingtons-disease-transgenic-mice-n430
[title] => Differential effects of early environmental enrichment on emotionality-related behaviours in Huntington's disease transgenic mice
[paragraph_crop] => Differential effects of early environmental enrichment on emotionality-related behaviours in [...]
[image_presente] =>
[date] => 2012-10-02 00:00:00
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[title] => Publications
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[id] => 398
[url] => https://bioseb.com/en/news/the-deletion-of-stop-and-map6-protein-in-mice-triggers-highly-altered-mood-and-impaired-cognitive-performances---n398
[title] => The deletion of STOP and MAP6 protein in mice triggers highly altered mood and impaired cognitive performances-
[paragraph_crop] => The deletion of STOP/MAP6 protein in mice triggers highly altered mood and impaired cognitive [...]
[image_presente] =>
[date] => 2012-04-30 00:00:00
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[title] => Publications
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[400] => Array
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[id] => 400
[url] => https://bioseb.com/en/news/a-functional-tph2-c1473g-polymorphism-causes-an-anxiety-phenotype-via-compensatory-changes-in-the-serotonergic-system---n400
[title] => A Functional Tph2 C1473G Polymorphism Causes an Anxiety Phenotype via Compensatory Changes in the Serotonergic System-
[paragraph_crop] => A Functional Tph2 C1473G Polymorphism Causes an Anxiety Phenotype via Compensatory Changes in [...]
[image_presente] =>
[date] => 2012-04-11 00:00:00
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[title] => Anxiety
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[link_rewrite] => Cross-disciplinary-subjects-
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[title] => Depression
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[87] => Array
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[id_prestablog_categorie] => 87
[title] => Phenotyping
[link_rewrite] => Phenotyping
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[2] => Array
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[id_prestablog_categorie] => 2
[title] => Publications
[link_rewrite] => publications
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[id_prestablog_categorie] => 58
[title] => Stress
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[393] => Array
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[id] => 393
[url] => https://bioseb.com/en/news/significantly-differential-diffusion-of-neuropathological-aggregates-in-the-brain-of-transgenic-mice-carrying-n-terminal-mutant-huntingtin-fused-with-green-fluorescent-protein--n393
[title] => Significantly differential diffusion of neuropathological aggregates in the brain of transgenic mice carrying N-terminal mutant huntingtin fused with green fluorescent protein-
[paragraph_crop] => Significantly differential diffusion of neuropathological aggregates in the brain of [...]
[image_presente] =>
[date] => 2012-03-16 00:00:00
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[id_prestablog_categorie] => 100
[title] => Cardiac function
[link_rewrite] => Cardiac-function
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[title] => Depression
[link_rewrite] => Depression
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[title] => Huntington's disease
[link_rewrite] => huntington-s-disease
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[title] => Mood disorders
[link_rewrite] => Mood-disorders
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[12] => Array
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[id_prestablog_categorie] => 12
[title] => Neurodegeneration
[link_rewrite] => Neurodegeneration
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[2] => Array
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[id_prestablog_categorie] => 2
[title] => Publications
[link_rewrite] => publications
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[389] => Array
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[id] => 389
[url] => https://bioseb.com/en/news/pramipexole-is-active-in-depression-tests-and-modulates-monoaminergic-transmission--but-not-brain-levels-of-bdnf-in-mice---n389
[title] => Pramipexole is active in depression tests and modulates monoaminergic transmission- but not brain levels of BDNF in mice-
[paragraph_crop] => Pramipexole is active in depression tests and modulates monoaminergic transmission, but not [...]
[image_presente] =>
[date] => 2012-02-29 00:00:00
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[title] => Depression
[link_rewrite] => Depression
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[title] => Mood disorders
[link_rewrite] => Mood-disorders
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[id_prestablog_categorie] => 12
[title] => Neurodegeneration
[link_rewrite] => Neurodegeneration
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[45] => Array
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[title] => Parkinson disease
[link_rewrite] => Parkinson-disease
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[2] => Array
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[id_prestablog_categorie] => 2
[title] => Publications
[link_rewrite] => publications
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[371] => Array
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[id] => 371
[url] => https://bioseb.com/en/news/increased-expression-of-the-vesicular-glutamate-transporter-1--vglut1--in-the-prefrontal-cortex-correlates-with-differential-vulnerability-to-chronic-stress-in-various-mouse-strains--effects-of-fluoxetine-and-mk-801---n371
[title] => Increased expression of the Vesicular Glutamate Transporter-1 -VGLUT1- in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains- Effects of fluoxetine and MK-801-
[paragraph_crop] => Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal [...]
[image_presente] =>
[date] => 2012-01-30 00:00:00
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[title] => Depression
[link_rewrite] => Depression
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[title] => Mood disorders
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[2] => Array
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[id_prestablog_categorie] => 2
[title] => Publications
[link_rewrite] => publications
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[title] => Stress
[link_rewrite] => Stress
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[363] => Array
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[id] => 363
[url] => https://bioseb.com/en/news/t-bet-deficient-mice-exhibit-resistance-to-stress-induced-development-of-depression-like-behaviors---n363
[title] => T-bet deficient mice exhibit resistance to stress-induced development of depression-like behaviors-
[paragraph_crop] => T-bet deficient mice exhibit resistance to stress-induced development of depression-like behaviors.
[image_presente] =>
[date] => 2011-12-15 00:00:00
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(
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[id_prestablog_categorie] => 57
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[link_rewrite] => Depression
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[title] => Mood disorders
[link_rewrite] => Mood-disorders
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[title] => Publications
[link_rewrite] => publications
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[id_prestablog_categorie] => 58
[title] => Stress
[link_rewrite] => Stress
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[356] => Array
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[id] => 356
[url] => https://bioseb.com/en/news/severe-serotonin-depletion-after-conditional-deletion-of-the-vesicular-monoamine-transporter-2-gene-in-serotonin-neurons--neural-and-behavioral-consequences---n356
[title] => Severe Serotonin Depletion after Conditional Deletion of the Vesicular Monoamine Transporter 2 Gene in Serotonin Neurons- Neural and Behavioral Consequences-
[paragraph_crop] => Severe Serotonin Depletion after Conditional Deletion of the Vesicular Monoamine Transporter 2 [...]
[image_presente] =>
[date] => 2011-11-03 00:00:00
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[title] => Depression
[link_rewrite] => Depression
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[title] => Mood disorders
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[2] => Array
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[id_prestablog_categorie] => 2
[title] => Publications
[link_rewrite] => publications
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[288] => Array
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[id] => 288
[url] => https://bioseb.com/en/news/the-deletion-of-the-microtubule-associated-stop-protein-affects-the-serotonergic-mouse-brain-network---n288
[title] => The deletion of the microtubule-associated STOP protein affects the serotonergic mouse brain network-
[paragraph_crop] => The deletion of the microtubule-associated STOP protein affects the serotonergic mouse brain [...]
[image_presente] =>
[date] => 2010-12-01 00:00:00
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[id_prestablog_categorie] => 57
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[link_rewrite] => Depression
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[id_prestablog_categorie] => 2
[title] => Publications
[link_rewrite] => publications
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[279] => Array
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[id] => 279
[url] => https://bioseb.com/en/news/antidepressant-like-effects-of-an-ampa-receptor-potentiator-under-a-chronic-mild-stress-paradigm--n279
[title] => Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm-
[paragraph_crop] => Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm.
[image_presente] =>
[date] => 2010-10-30 00:00:00
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[title] => Depression
[link_rewrite] => Depression
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[15] => Array
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[title] => Mood disorders
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[2] => Array
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[id_prestablog_categorie] => 2
[title] => Publications
[link_rewrite] => publications
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[264] => Array
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[id] => 264
[url] => https://bioseb.com/en/news/behavioural-and-neuroplastic-effects-of-the-new-generation-antidepressant-agomelatine-compared-to-fluoxetine-in-glucocorticoid-receptor-impaired-mice---n264
[title] => Behavioural and neuroplastic effects of the new-generation antidepressant agomelatine compared to fluoxetine in glucocorticoid receptor-impaired mice-
[paragraph_crop] => Behavioural and neuroplastic effects of the new-generation antidepressant agomelatine compared [...]
[image_presente] =>
[date] => 2010-07-30 00:00:00
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[id_prestablog_categorie] => 57
[title] => Depression
[link_rewrite] => Depression
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[title] => Mood disorders
[link_rewrite] => Mood-disorders
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[2] => Array
(
[id_prestablog_categorie] => 2
[title] => Publications
[link_rewrite] => publications
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)
[254] => Array
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[id] => 254
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[title] => Antidepressant-like effect of the methanolic extract from Bupleurum falcatum in the tail suspension test-
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[title] => Subchronic Alpha-Linolenic Acid Treatment Enhances Brain Plasticity and Exerts an Antidepressant Effect- A Versatile Potential Therapy for Stroke-
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[title] => Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease-
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[title] => Lasting Syndrome of Depression Produced by Reduction in Serotonin Uptake during Postnatal Development- Evidence from Sleep- Stress- and Behavior-
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[title] => The tail suspension test as a model for assessing antidepressant activity- Review of pharmacological and genetic studies in mice-
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[url] => https://bioseb.com/en/news/stress-induced-anhedonia-in-mice-is-associated-with-deficits-in-forced-swimming-and-exploration--n24
[title] => Stress-Induced Anhedonia in Mice is Associated with Deficits in Forced Swimming and Exploration-
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[title] => Genetic and Pharmacological Evidence of a Role for GABAB Receptors in the Modulation of Anxiety- and Antidepressant-Like Behavior-
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1Number of publications:
NEW ! A complete (hardware + software), dedicated and automated solution for the Elevated Plus Maze test, featuring...
A unique setup for the automation of the Open Field test for rats and mice : 3D-camera based technology is now capable of...
Open-field test - ARENA ONLY - used to evaluate of animal's basal activity and its evolution for rodents (rats and mice) in...
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