Motor training compensates for cerebellar dysfunctions caused by oligodendrocyte ablation-

Authors
L. Collin, A. Usiello, E. Erbs, C. Mathis, E. Borrelli.

Lab
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Molecular Neurobiology, Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Médicale/Universite Louis Pasteur, Illkirch, France.

Journal
PNAS, Proceedings of the National Academy of Sciences of the United States of America

Abstract
The role played by oligodendrocytes (OLs), the myelinating cells of the CNS, during brain development has not been fully explored. We have addressed this question by inducing a temporal and reversible ablation of OLs on postnatal CNS development. OL ablation in newborn mice leads to a profound alteration in the structure of the cerebellar cortex, which can be progressively rescued by newly generated cells, leading to a delayed myelination. Nevertheless, the temporal shift of the OL proliferation and myelinating program cannot completely compensate for developmental defects, resulting in impaired motor functions in the adult. Strikingly, we show that, despite these abnormalities, epigenetic factors, such as motor training, are able to fully rescue cerebellar-directed motor skills.

BIOSEB Instruments Used:
Aron Test or Four Plates Test (LE830),Rotarod (BX-ROD)