Activity, Motor Control & Coordination
Pain - Thermal Allodynia / Hyperalgesia
Pain - Spontaneous Pain - Postural Deficit
Pain - Mechanical Allodynia / Hyperalgesia
Anxiety & Depression Disorder
Learning/Memory - Attention - Addiction
Physiology & Respiratory Research
Metabolism - Food & Drink Intake
Pain
Metabolism
Motor control
Neurodegeneration
Cross-disciplinary subjects
Muscular system
General activity
Mood Disorders
Other disorders
Joints
Central Nervous System (CNS)
Sensory system
Authors
Y. Zengin-Toktas, J. Ferrier, F. Durif, PM. Llorca et N. Authier.
Lab
INSERM 1107, NEURO-DOL, Clermont-Ferrand, France
Journal
Neuroscience Research
Abstract
Some patients with Parkinson's disease (PD) suffer from pain before motor symptoms. To model this, we proposed to assess the mechanical hypersensitivity in an animal model of PD with a bilateral lesion of the nigrostriatal pathway. PD model was validated by a decrease of locomotor activity and a 76% dopamine cell loss in the substantia nigra pars compacta. PD animals displayed a decrease of mechanical thresholds, correlated with the degree of the dopamine lesion. This animal model displays nociceptive disorders as found in PD patients and could be useful to assess the effects of new antiparkinsonian drugs.
BIOSEB Instruments Used:
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
