K Afshari, A Dehdashtian, N-S Haddadi, A Haj-Mirzaian, A Iranmehr, M Ali Ebrahimi, SM Tavangar, H Faghir-Ghanesefat, F Mohammadi, N Rahimi, AN Javidan, A R Dehpou
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
Metformin is a safe drug for controlling blood sugar in diabetes. It has been shown that metformin improves locomotor recovery after spinal cord injury (SCI). Neuropathic pain is also a disturbing component of SCI. It is indicated that metformin has neuroprotective and anti-inflammatory effects, which attenuate neuropathic pain and hyperalgesia in injured nerves. Thus, we evaluated metforminâ€™s therapeutic effects on SCI neuroinflammation and its sensory and locomotor complications. Meanwhile, results were compared to minocycline, an anti-neuroinflammation therapy in SCI.
BIOSEB Instruments Used:
Von Frey Filaments (Bio-VF-M)