Activity, Motor Control & Coordination
Pain - Thermal Allodynia / Hyperalgesia
Pain - Spontaneous Pain - Postural Deficit
Pain - Mechanical Allodynia / Hyperalgesia
Anxiety & Depression Disorder
Learning/Memory - Attention - Addiction
Physiology & Respiratory Research
Metabolism - Food & Drink Intake
Pain
Metabolism
Motor control
Neurodegeneration
Cross-disciplinary subjects
Muscular system
General activity
Mood Disorders
Other disorders
Joints
Central Nervous System (CNS)
Sensory system
Authors
K Afshari, A Dehdashtian, N-S Haddadi, A Haj-Mirzaian, A Iranmehr, M Ali Ebrahimi, SM Tavangar, H Faghir-Ghanesefat, F Mohammadi, N Rahimi, AN Javidan, A R Dehpou
Lab
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
Journal
Spinal Chord
Abstract
Metformin is a safe drug for controlling blood sugar in diabetes. It has been shown that metformin improves locomotor recovery after spinal cord injury (SCI). Neuropathic pain is also a disturbing component of SCI. It is indicated that metformin has neuroprotective and anti-inflammatory effects, which attenuate neuropathic pain and hyperalgesia in injured nerves. Thus, we evaluated metformin’s therapeutic effects on SCI neuroinflammation and its sensory and locomotor complications. Meanwhile, results were compared to minocycline, an anti-neuroinflammation therapy in SCI.
BIOSEB Instruments Used:
Von Frey Filaments (Bio-VF-M)
