Assessment of the effects of exercise on a murine model of OA
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C. Huesa, L. Dunning, K. MacDougall, A. Ortiz, M. Villaluz, M. Fegen, A. Crilly, G. Litherland, R. van t Hof, C. Goodyear, J.C. Lockhart

Univ. of the West of Scotland, Glasgow, United Kingdom

Osteoarthritis and Cartilage

International guidelines recommend exercise to delay rapid progression of osteoarthritis (OA). Numerous studies have shown that land-based exercise regimes, when performed regularly, leads to an improvement in joint mobility and pain. In vivo models of OA mimic many of the parameters of post-traumatic human OA. Destabilization of the medial meniscus (DMM) in rodents results in progressive development of OA with cartilage damage, osteosclerosis, mild synovitis, ligament damage/calcification and osteophyte formation.

BIOSEB Instruments Used:
Activmeter (BIO-ACTIV-R)

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