Activity, Motor Control & Coordination
Pain - Thermal Allodynia / Hyperalgesia
Pain - Spontaneous Pain - Postural Deficit
Pain - Mechanical Allodynia / Hyperalgesia
Anxiety & Depression Disorder
Learning/Memory - Attention - Addiction
Physiology & Respiratory Research
Metabolism - Food & Drink Intake
Pain
Metabolism
Motor control
Neurodegeneration
Cross-disciplinary subjects
Muscular system
General activity
Mood Disorders
Other disorders
Joints
Central Nervous System (CNS)
Sensory system
Authors
R. Lalonde, J. Eyer, V. Wunderle, C. Strazielle.
Lab
Faculté de Médecine et de Pharmacie, Université de Rouen, INSERM EMI 9906, Rouen, France ; CHUM/Hôtel-Dieu, Service de Neurologie, Montreal, Canada ; Université d’Angers, Laboratoire de Neurobiologie et Transgénèse, Angers, France ; Faculté de Médecine, L
Journal
Behavioural Processes
Abstract
NFH-LacZ transgenic mice express a fusion protein between a truncated form of the endogenous neurofilament of heavy molecular weight and the complete E. coli _-galactosidase. NFH-LacZ transgenic mice could be distinguished from controls in the SHIRPA neurological battery by the appearance of action tremor and hindlimb clasping and a lower body weight. Despite normal exploratory activity and spatial learning, NFH-LacZ transgenic mice were deficient in stationary beam, coat-hanger, and rotorod tests of motor coordination. These results are concordant with neuropathological findings in spinal motoneurons and the cerebellum and indicate that despite the absence of paralysis, these transgenic mice may serve as an experimental model of the early stage of amyotrophic lateral sclerosis.
BIOSEB Instruments Used:
Acquisition software: ACTITRACK (ACTITRACK),Infrared Actimeter (LE8815)
