Headache outcomes following treatment of unruptured intracranial aneurysms- A prospective analysis-
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- Categories : Miscellaneous research domains , Publications - ID: 333

T. Schwedt, R. Gereau 4th, K. Frey, E. Kharasch.

Washington University School of Medicine, USA. schwedtt@neuro.wustl.edu


OBJECTIVE: To analyze headache patterns prior to and following treatment of unruptured intracranial aneurysms and identify factors associated with different headache outcomes. METHODS: A prospective observational study of patients being treated for unruptured intracranial aneurysms. Headache patterns were established prior to aneurysm treatment and for 6 months following treatment. Factors associated with different headache outcomes were investigated. RESULTS: In all patients (n_=_44), 90-day headache frequency decreased from an average of 31 days prior to aneurysm treatment to 17 days following treatment (p_<_0.001). In patients with active pretreatment headaches (n_=_28), 90-day headache frequency decreased from 49 days to 26 days (p_=_0.002). Headache frequency was reduced in 68% of patients, while 9% of patients had new or worsened headaches following aneurysm treatment. Pretreatment migraine, more severe pretreatment headaches, higher pretreatment trait anxiety, and stent-assisted aneurysm coiling were associated with a lack of headache improvement. CONCLUSIONS: The majority of patients with headaches at the time of aneurysm treatment had reductions in headache frequency during the 6 months following treatment. Potential risk factors for poor headache outcomes were identified but need to be studied further.

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