Activity, Motor Control & Coordination
Pain - Thermal Allodynia / Hyperalgesia
Pain - Spontaneous Pain - Postural Deficit
Pain - Mechanical Allodynia / Hyperalgesia
Anxiety & Depression Disorder
Learning/Memory - Attention - Addiction
Physiology & Respiratory Research
Metabolism - Food & Drink Intake
Pain
Metabolism
Motor control
Neurodegeneration
Cross-disciplinary subjects
Muscular system
General activity
Mood Disorders
Other disorders
Joints
Central Nervous System (CNS)
Sensory system
Authors
S Zhao, F Wang, L Wang et al
Lab
The Third Hospital of HebeiMedical University, Shijiazhuang, Hebei Province, China.
Journal
Brain and Behavior
Abstract
Brachial plexus avulsion significantly increased brain-derived neu rotrophic factor (BDNF) release in the spinal cord. Here we investigated the involve ment of the BDNFÐTrkBÐKCC2 pathway in neuropathic pain caused by BPA injury. We hypothesized that activation of BDNFÐTrkB may inhibit neuronal excitability by down regulating KCC2 to maintain a high intracellular Cl-concentration. We established a neuropathic pain rat model by avulsion of the lower trunk brachial plexus, and inves tigated the effects of the TrkB-specific antibody K-252a on the expression of BDNF, TrkB, and KCC2
BIOSEB Instruments Used:
Electronic Von Frey 5 with embedded camera (BIO-EVF5),Electronic Von Frey 4 (BIO-EVF4)
