Neurobiological effects of repeated radiofrequency exposures in male senescent rats
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- Categories : Miscellaneous research domains , Publications - ID: 884

Authors
Bouji M, Lecomte A, Gamez C, Blazy K, Villégier AS et al.


Lab
Unité de Toxicologie Expérimentale, Institut National de l'Environnement Industriel et des Risques (INERIS), Parc Technologique ALATA, BP no. 2, 60550, Verneuil-en-Halatte, France

Journal
Biogerontology.

Abstract
The increasing use of mobile phones by aging people raises issues about the effects of radiofrequency electromagnetic fields (RF-EMF) on the aging central nervous system. Here, we tested if mobile phone RF-EMF exposures could exacerbate senescence-typical neurobiological deficits. Thus, aged (22-24 months) and young (4-6 months) adult male rats were subjected to head RF-EMF exposures (900 MHz, specific absorption rate (SAR) of 6 W/kg, 45 min/day for 1 month in restraint rockets). To assess senescence-typical neurobiological deficits, spatial memory, emotional memory, anxiety-related behavior, locomotor activity, interleukins (IL)-1β and 6, glial fibrillary acidic protein and corticosterone were measured. Aged rats presented deficits in spatial learning, exploration, anxiety-related behaviors, and increased hippocampal ILs and cortical IL-1β. Results showed that senescence-typical neurobiological deficits were not modified by RF-EMF exposures. RF-EMF-exposed rats (young and aged adults pooled) had decreased anxiety-related behaviors in the elevated plus maze. This study which is the first to assess RF-EMF exposures during late aging did not support the hypothesis of a specific cerebral vulnerability to RF-EMF during senescence. More investigations using longer RF-EMF exposures should be performed to conclude regarding the inoffensiveness of RF-EMF exposures.

BIOSEB Instruments Used:
Startle and Fear System (BX-START&FEAR)

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