Sequential alteration of microglia and astrocytes in the rat thalamus following spinal nerve ligation
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- Categories : Neuropathic pain , Pain , Publications

Authors
L Blaszczyk, M Ma


Lab
Bordeaux University, and Neurocentre Magendie, INSERM U1215, Bordeaux, France

Journal
Journal of Neuroinflammation

Abstract
Background Spinal reactive astrocytes and microglia are known to participate to the initiation and maintenance of neuropathic pain. However, whether reactive astrocytes and microglia in thalamic nuclei that process sensory-discriminative aspects of pain play a role in pain behavior remains poorly investigated. Therefore, the present study evaluated whether the presence of reactive glia (hypertrophy, increased number and upregulation of glial markers) in the ventral posterolateral thalamic nucleus (VPL) correlates with pain symptoms, 14 and 28

BIOSEB Instruments Used:
Dynamic Weight Bearing 2.0 (BIO-DWB-DUAL)

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