Small Extracellular Vesicles Derived From Human Ipsc-Derived MSC Ameliorate Tendinopathy-Related Acute Pain Through Inhibiting Mast Cells Activation

Authors
R Gao, T Ye, Z Zhu et al


Lab
Shanghai Jiao Tong University Affiliated Sixth People' Hospitaliated to Shanghai Jiaotong University

Journal
ResearchSquare

Abstract
Acute pain is the primary symptom of tendinopathy, and mast cells activation is a nonnegligible cause. Currently, safe and effective treatment for acute pain in tendinopathy is still lacking. This study was aimed to explore the analgesic effect of iPSC-derived mesenchymal stem cell-derived small extracellular vesicles (iMSC-sEVs) on acute pain and further investigate the underlying mechanisms in tendinopathy.

BIOSEB Instruments Used:
Electronic Von Frey 5 with embedded camera (BIO-EVF5),Static Weight Bearing Touch: Incapacitance Test (BIO-SWB-TOUCH-M),Electronic Von Frey 4 (BIO-EVF4)

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