Activity, Motor Control & Coordination
Pain - Thermal Allodynia / Hyperalgesia
Pain - Spontaneous Pain - Postural Deficit
Pain - Mechanical Allodynia / Hyperalgesia
Anxiety & Depression Disorder
Learning/Memory - Attention - Addiction
Physiology & Respiratory Research
Metabolism - Food & Drink Intake
Pain
Metabolism
Motor control
Neurodegeneration
Cross-disciplinary subjects
Muscular system
General activity
Mood Disorders
Other disorders
Joints
Central Nervous System (CNS)
Sensory system
Authors
M. Dumont, C. Strazielle, M. Staufenbiel, R. Lalonde.
Lab
Université de Rouen, INSERM U614, IFRMP23, Faculté de Médecine et de Pharmacie, Rouen, France ; CHUM/St-Luc, Centre de Recherche en Sciences Neurologiques, Montréal, Canada.
Journal
Brain Research
Abstract
Transgenic mice overexpressing the _APP gene with the Swedish mutation under the control of the murine thy1 promoter show Alzheimer-like characteristics such as A_ plaques in cerebral cortex and vessel walls. By comparison to age-matched non-transgenic controls, 2-year-old female APP23 transgenic mice crossed more segments in the open-field and had a higher number of fast ambulatory and stereotyped movements in a photocell activity chamber. In addition, APP23 mice entered more often and spent more time in the open arms of the elevated plus-maze. The acquisition of place learning in the Morris water maze was impaired in APP23 transgenic mice, but not in probe and visible platform subtasks. These results indicate that hyperactivity and impaired learning abilities characterize this mouse model of Alzheimer's disease and cerebral angiopathy.
BIOSEB Instruments Used:
Acquisition software: ACTITRACK (ACTITRACK),Infrared Actimeter (LE8815)
