The antidepressant-and anxiolytic-like activities of new xanthone derivative with piperazine moiety in behavioral tests in mice
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- Categories : Miscellaneous research domains , Publications - ID: 878

Authors
Pytka K, Żmudzka E, Lustyk K, Rapacz A, Olczyk A, Gałuszka A, Waszkielewicz A, Marona H, Sapa J, Barbara F


Lab
Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, 30-688 Krakow, Poland

Journal
Indian J Pharmacol.

Abstract
OBJECTIVES:

Xanthones are flavonoids with numerous activities, including antioxidant, antidepressant., or anxiolytic-like. Therefore, the aim of our study was to determine antidepressant- and anxiolytic-like properties of four xanthone derivatives (3-chloro-5-[(4-methylpiperazin-1-yl)methyl]-9H-xanthen-9-one dihydrochloride [HBK-5], 6-methoxy-2-[(4-methylpiperazin-1-yl) methyl]-9H-xanthen-9-one dihydrochloride, 2-[(4-benzylpiperazin-1-yl) methyl]-6-methoxy-9H-xanthen-9-one dihydrochloride, 2-{[4-(2-methoxyphenyl) piperazin-1-yl] methyl}-9H-xanthen-9-one hydrochloride), as well as the influence on cognitive and motor function of active compounds, using animal models.

MATERIALS AND METHODS:

To determine the antidepressant-like activity, we used forced swim test (FST) and tail suspension test (TST) in mice. We evaluated anxiolytic-like properties in the four-plate test in mice. We studied the influence on cognitive and motor function in passive avoidance step-through and chimney tests, respectively.

RESULTS:

The antidepressant-like activity (in both FST and TST) showed only HBK-5. Moreover, the compound was also active in the four-plate test, which suggests that it possessed anxiolytic-like properties. HBK-5 did not cause any cognitive and motor deficits in mice at antidepressant- and anxiolytic-like doses.

CONCLUSIONS:

HBK-5 may have potential in the treatment of depression or anxiety disorders, but this issue needs further studies.

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