The influence of spatial pulsed magnetic field application on neuropathic pain after tibial nerve transection in rat
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- Categories : Miscellaneous research domains , Publications - ID: 557

Authors
S. Szajkowski1, W. Marcol, A. Właszczuk, G. Cieślar, M. Pietrucha-Dutczak et al.


Lab
Medical University of Silesia, Katowice, Poland

Journal
Electromagnetic Biology and Medicine

Abstract
The purpose of the study was to examine the influence of the spatial variable magnetic field (induction: 150–300 µT, 80–150 µT, 20–80 µT; frequency 40 Hz) on neuropathic pain after tibial nerve transection. The experiments were carried out on 64 male Wistar C rats. The exposure of animals to magnetic field was performed 1 d/20 min., 5 d/week, for 28 d. Behavioural tests assessing the intensity of allodynia and sensitivity to mechanical and thermal stimuli were conducted 1 d prior to surgery and 3, 7, 14, 21 and 28 d after the surgery. The extent of autotomy was examined. Histological and immunohistochemical analysis was performed. The use of extremely low-frequency magnetic fields of minimal induction values (20–80 µT/40 Hz) decreased pain in rats after nerve transection. The nociceptive sensitivity of healthy rats was not changed following the exposition to the spatial magnetic field of the low frequency. The results of histological and immunohistochemical investigations confirm those findings. Our results indicate that extremely low-frequency magnetic field may be useful in the neuropathic pain therapy.

BIOSEB Instruments Used:
Cold Hot Plate Test (BIO-CHP)

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