The protective effects of sumatriptan on vincristine-induced peripheral neuropathy in a rat model

Authors
Khalilzadeh M, Panahi G, Rashidian A, Hadian MR, Abdollahi A, Afshari K, Shakiba S, Norouzi-Javidan A, Rahimi N, Momeny M, Dehpour AR


Lab
Tehran University of Medical Sciences, Tehran, Iran

Journal
Neurotoxicology

Abstract
A recently developed transdermal fentanyl solution was hypothesized to be effective for non-invasive postoperative analgesia in rats. MATERIALS AND METHODS: Thirty-nine male Sprague-Dawley rats were treated once with 0.1, 0.33 or 1.0 mg/kg transdermal fentanyl solution at the skin of the scruff 1 h prior to subjected to hind-paw surgery, and compared to non-treated animals. All rats were tested for nociceptive response in the electronic von Frey (EVF) test between 1 and 72 h postoperatively, and assessed daily with regards to facial expression, body weight changes and welfare score. RESULTS: Fentanyl treatment at all doses significantly reduced nociceptive response in the EVF test throughout the 72 h of experimentation, reduced facial expressions on all days postoperatively, slightly reduced the body weight and improved postoperative welfare parameters. CONCLUSION: The present study indicates that transdermal fentanyl solution seems to be an effective, non-invasive and long-lasting analgesic regimen in male rats.

BIOSEB Instruments Used:
Von Frey Filaments (Bio-VF-M)

Related products

Publication request

Thank you for your interest in our product range and your request for this publication, which will be sent to you if the research team and the journal allow it. Our commercial team will contact you as soon as possible.