Parkinson disease - page 2 Scientific Publications

Latest publication 09/24/2020

Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and t

Several lines of evidence indicate that the propagation of misfolded alpha_synuclein (alpha_syn) plays a central role in the progression and...

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    [title] => Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and t
    [paragraph] => Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a_synuclein in mouse brain
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Authors
V Samantha Sykioti, M Karampetsou, I Chalatsa et al

 Lab
Center for Basic Research, Biomedical Research Foundation Academy of Athens, Athens, Greece
Journal
Journal of Neurochemistry
Abstract
Several lines of evidence indicate that the propagation of misfolded alpha_synuclein (alpha_syn) plays a central role in the progression and manifestation of ParkinsonÕs disease. Pathogenic alpha_syn species can be present in the extracellular space. Thus, the identification and modulation of the key enzymes implicated in extracellular alpha_syn turnover becomes vital.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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