Jump Test

Presentation

Following the publications of I. Yalcin et al. (The Journal of Pain, 2009) and complementary works from team of Dr Bourinet (EMBO J.Descoeur et al, 2011) regarding hypersensitivity to cold stimulus, BIOSEB has developed an entirely new set-up for the evaluation of the escaping behaviour of mice experimenting a ramp of temperature (cold and hot) over an aluminium plate.

The entire instrument is based on our popular Hot and cold Plate hardware, built around a metal plate which can be heated to 65°C and cooled to -3°C (with an ambient temperature between 20°C and 25°C), which already opened new investigation fields for your analgesia and nociception research. The classical setting is completed with a special back lighting plate and a HD camera sensitive to the back light wavelength placed in front of the Hot and Cold Plate.

The test has been mostly used to measure pharmacological effects of cancer treatment to cold sensitivity on mice.

Operating principle

A ramp is generally programmed from 30°C to 1 °C and the distribution of jump recorded over the whole experiment. Metrology wise, the Jump Test is accurate to less than 0,5°C (EEC metrology standard) and perfectly constant in the animal holder system.

The JUMP TEST is an automatic analgesia apparatus which frees time to the experimenter to perform other works on bench. It secures the counting, and stores video as a backup if additional evaluation is needed later.