Activity, Motor Control & Coordination
Pain - Thermal Allodynia / Hyperalgesia
Pain - Spontaneous Pain - Postural Deficit
Pain - Mechanical Allodynia / Hyperalgesia
Anxiety & Depression Disorder
Learning/Memory - Attention - Addiction
Physiology & Respiratory Research
Metabolism & Nutrition
Contextual Kits for T2CT - Dual Aversion & CPP
The Contextual Kits for T2CT have been designed to enhance thermal place preference studies...
![Dynamic Weight Bearing 2.0 – Postural Module [Add-on]](https://bioseb.com/733-home_default/dynamic-weight-bearing-20-add-on-postural-module.jpg)
Pain
Central Nervous System (CNS)
Neurodegeneration
Sensory system
Motor control
Mood Disorders
Other disorders
Muscular system
Joints
Metabolism
Cross-disciplinary subjects
CONFERENCES & MEETINGS 
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Cold Hot Plate Test
Reference : BIO-CHP
Category : Pain - Thermal Allodynia / Hyperalgesia
For testing animal's thermal sensitivity to pain resulting from exposure to heat or cold: the Cold Hot Plate is an innovative instrument opening new investigation fields for your analgesia and nociception research, and a useful tool for analgesic drug screening using rats or mice models.
Presentation
Bioseb’s Cold and Hot Plate Test is an innovative instrument opening new investigation fields for your analgesia research by allowing you to test animal's sensitivity to pain resulting from exposure to heat or cold.
This innovative Analgesia Meter is based on a metal plate which can be heated to 55°C and cooled to -2°C (with an ambient temperature between 20°C and 25°C). An electronic thermostat maintains the plate's temperature and a front panel digital thermometer displays the current plate temperature.
The Bioseb Cold and Hot Plate is designed to be very simple to use and very fast to reach the set temperature (as example From ambient to 4°C, the most used threshold value, it takes less than 10 minutes, and from 4°C to 55°C it takes only 5 minutes). Metrology wise, is accurate to less than 0,5°C (EEC metrology standard) and perfectly constant in the animal holder system. The preset temperature will not change for more than 0,1°C when a 400g rat is placed on the plate, and return to the set temperature is almost immediate.
Operation Principle
The animal's pain sensitivity resulting from exposure to heat or cold is tested by placing the animal (mouse or rat) on the surface of the plate and starting a built-in timer. The operator stops the timer at the instant the animal lifts its paw from the plate, reacting to the discomfort. The front panel timer then displays the number of seconds it took the animal to react. Animal reaction time is a measurement of animal resistance to pain and is used to measure efficacy of analgesics.
The operator can start and stop the timer with the front panel start/stop switch or with the included footswitch, which allows 'hands-free' operation.
BIO-CHP
Data sheet
- Dimensions - Animal container
- Plate dimensions 165 x 165 mm
- Dimensions - Overall
- Control unit dimensions 305 x 280 x 158 mm
- Power supply
- 110V/220V automatic, 100W
- Range
- -2 degrees C. to 55 degrees C (in 20 to 25 degree C. ambient environment, 50% RH)
- Applications
- Central Nervous System (CNS)
Cognitive performance
Cross-disciplinary subjects
General Activity
Metabolism
Mood Disorders
Motor Control
Neurodegeneration
Pain
Sensory system - Accuracy
- Temp accuracy +/- 0.5 degrees C.
Temperature uniformity on plate +/- 0.5 degrees C.
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[title] => Analgesic properties of dealcoholized extract of Acorus Calamus Leaves
[paragraph_crop] => Analgesic properties of dealcoholized extract of Acorus Calamus Leaves
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[date] => 2021-09-30 00:00:00
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[title] => Neurogenesis in the adult brain functionally contributes to the maintenance of chronic neuropathic pain
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[title] => Involvement of the nociceptin opioid peptide receptor in morphine-induced antinociception- tolerance and physical dependence in female mice
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[title] => Disrupting phosphorylation of Tyr-1070 at GluN2B selectively produces resilience to depression-like behaviors
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[date] => 2021-08-24 00:00:00
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[title] => Gastrodia elata Blume Polysaccharides Attenuate Vincristine-Evoked Neuropathic Pain through the Inhibition of Neuroinflammation
[paragraph_crop] => Gastrodia elata Blume Polysaccharides Attenuate Vincristine-Evoked Neuropathic Pain through [...]
[image_presente] =>
[date] => 2021-07-28 00:00:00
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[title] => Inflammatory pain
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[url] => https://bioseb.com/en/news/pain-hypersensitivity-in-a-pharmacological-mouse-model-of-attention-deficithyperactivity-disorder-adhd-n1465
[title] => Pain hypersensitivity in a pharmacological mouse model of Attention-Deficit/Hyperactivity Disorder (ADHD)
[paragraph_crop] => Pain hypersensitivity in a pharmacological mouse model of Attention-Deficit/Hyperactivity [...]
[image_presente] =>
[date] => 2021-04-23 00:00:00
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[title] => Decision-making
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[url] => https://bioseb.com/en/news/trpv1-is-involved-in-the-antinociceptive-effects-of-resveratrol-in-paclitaxel-induced-neuropathic-pain-n1355
[title] => TRPV1 is involved in the antinociceptive effects of resveratrol in paclitaxel-induced neuropathic pain
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[image_presente] =>
[date] => 2021-01-04 00:00:00
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[url] => https://bioseb.com/en/news/preventing-oxaliplatininduced-neuropathic-pain--using-berberine-to-inhibit-the-activation-of-nfkappab-and-release-of-proinflammatory-cytokines-in-dorsal-root-ganglions-in-rats-preventing-oxaliplatininduced-neuropathic-pain--using-berberine-to-inhibit--n1346
[title] => Preventing oxaliplatin_induced neuropathic pain- Using berberine to inhibit the activation of NF_kappaB and release of pro_inflammatory cytokines in dorsal root ganglions in rats Preventing oxaliplatin_induced neuropathic pain- Using berberine to inhibit
[paragraph_crop] => Preventing oxaliplatin_induced neuropathic pain: Using berberine to inhibit the activation of [...]
[image_presente] =>
[date] => 2020-12-10 00:00:00
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[url] => https://bioseb.com/en/news/selective-activation-of-metabotropic-glutamate-receptor-7-blocks-paclitaxel-induced-acute-neuropathic-pain-and-suppresses-spinal-glial-reactivity-in-rats-n1328
[title] => Selective activation of metabotropic glutamate receptor 7 blocks paclitaxel-induced acute neuropathic pain and suppresses spinal glial reactivity in rats
[paragraph_crop] => Selective activation of metabotropic glutamate receptor 7 blocks paclitaxel-induced acute [...]
[image_presente] =>
[date] => 2020-10-20 00:00:00
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[url] => https://bioseb.com/en/news/puerarin-alleviates-vincristine-induced-neuropathic-pain-and-neuroinflammation-via-inhibition-of-nuclear-factor-kappab-and-activation-of-the-tgf-beta-and-smad-pathway-in-rats-n1331
[title] => Puerarin alleviates vincristine-induced neuropathic pain and neuroinflammation via inhibition of nuclear factor-kappaB and activation of the TGF-beta-and-Smad pathway in rats
[paragraph_crop] => Puerarin alleviates vincristine-induced neuropathic pain and neuroinflammation via inhibition [...]
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[date] => 2020-10-10 00:00:00
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[url] => https://bioseb.com/en/news/curcumin-cyclodextrin-and-cellulose-nanocrystals-improve-the-phenotype-of-charcot-marie-tooth-1a-transgenic-rats-through-the-reduction-of-oxidative-stress-n1307
[title] => Curcumin-cyclodextrin and cellulose Nanocrystals Improve the Phenotype of Charcot-Marie-Tooth-1A Transgenic Rats Through the Reduction of Oxidative Stress
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[date] => 2020-09-25 00:00:00
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[title] => Motor Deficits
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[url] => https://bioseb.com/en/news/deep-posteromedial-cortical-rhythm-in-dissociation-n1305
[title] => Deep posteromedial cortical rhythm in dissociation
[paragraph_crop] => Deep posteromedial cortical rhythm in dissociation
[image_presente] =>
[date] => 2020-09-16 00:00:00
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[url] => https://bioseb.com/en/news/forward-genetics-identifies-a-novel-sleep-mutant-with-sleep-state-inertia-and-rem-sleep-deficits-n1297
[title] => Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits
[paragraph_crop] => Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits
[image_presente] =>
[date] => 2020-08-12 00:00:00
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[title] => Sleep
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[id] => 1287
[url] => https://bioseb.com/en/news/behavioral-tests-assessing-neuropsychiatric-phenotypes-in-adolescent-mice-reveal-strain--and-sex-specific-effects-n1287
[title] => Behavioral tests assessing neuropsychiatric phenotypes in adolescent mice reveal strain- and sex-specific effects
[paragraph_crop] => Behavioral tests assessing neuropsychiatric phenotypes in adolescent mice reveal strain- and [...]
[image_presente] =>
[date] => 2020-07-09 00:00:00
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[title] => Cognitive performance
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[url] => https://bioseb.com/en/news/baicalin-prevents-the-upregulation-of-trpv1-in-dorsal-root-ganglion-and-attenuates-chronic-neuropathic-pain-n1286
[title] => Baicalin prevents the up_regulation of TRPV1 in dorsal root ganglion and attenuates chronic neuropathic pain
[paragraph_crop] => Baicalin prevents the up_regulation of TRPV1 in dorsal root ganglion and attenuates chronic [...]
[image_presente] =>
[date] => 2020-06-01 00:00:00
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[title] => Neuropathic pain
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[id] => 1264
[url] => https://bioseb.com/en/news/chronic-morphine-regulates-trpm8-channels-via-mor-pkcbeta-signaling-n1264
[title] => Chronic morphine regulates TRPM8 channels via MOR-PKCbeta signaling
[paragraph_crop] => Chronic morphine regulates TRPM8 channels via MOR-PKCbeta signaling
[image_presente] =>
[date] => 2020-04-14 00:00:00
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[id_prestablog_categorie] => 48
[title] => Hot & Cold Perception
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[title] => Publications
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[title] => Sensory system
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[1262] => Array
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[id] => 1262
[url] => https://bioseb.com/en/news/testosteroneandrogen-receptor--the-steroid-link-inhibiting-trpm8mediated-cold-sensitivity-n1262
[title] => Testosterone_androgen receptor- The steroid link inhibiting TRPM8_mediated cold sensitivity
[paragraph_crop] => Testosterone_androgen receptor: The steroid link inhibiting TRPM8_mediated cold sensitivity
[image_presente] =>
[date] => 2020-03-18 00:00:00
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[id_prestablog_categorie] => 48
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[title] => Publications
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[id_prestablog_categorie] => 13
[title] => Sensory system
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[1214] => Array
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[id] => 1214
[url] => https://bioseb.com/en/news/loss-of-bhlha9-impairs-thermotaxis-and-formalin-evoked-pain-in-a-sexually-dimorphic-manner-n1214
[title] => Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner
[paragraph_crop] => Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner
[image_presente] =>
[date] => 2020-01-21 00:00:00
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[title] => Sensory system
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[title] => Somatosensory system
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[id] => 1208
[url] => https://bioseb.com/en/news/baicalin-ameliorates-bone-cancer-pain-by-suppressing-trpv1-in-rat-dorsal-root-ganglia--n1208
[title] => Baicalin Ameliorates Bone Cancer Pain by Suppressing TRPV1 in Rat Dorsal Root Ganglia
[paragraph_crop] => Baicalin Ameliorates Bone Cancer Pain by Suppressing TRPV1 in Rat Dorsal Root Ganglia
[image_presente] =>
[date] => 2020-01-08 00:00:00
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[title] => Cancer
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[title] => Cross-disciplinary subjects
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[1203] => Array
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[id] => 1203
[url] => https://bioseb.com/en/news/analgesic-and-antiallodynic-activity-of-novel-anticonvulsant-agents-derived-from-3-benzhydryl-pyrrolidine-2-5-dione-in-mouse-models-of-nociceptive-and-neuropathic-pain-n1203
[title] => Analgesic and antiallodynic activity of novel anticonvulsant agents derived from 3-benzhydryl-pyrrolidine-2-5-dione in mouse models of nociceptive and neuropathic pain
[paragraph_crop] => Analgesic and antiallodynic activity of novel anticonvulsant agents derived from [...]
[image_presente] =>
[date] => 2019-12-19 00:00:00
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[title] => Neuropathic pain
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[url] => https://bioseb.com/en/news/bioscreening-of-the-spacerized-complex-bis--2-pyridyl--3--1--2--4-triazolyl--propane-and-11-hydroxy-1--1-ethylidenediphosphonic-acid-n1189
[title] => Bioscreening of the spacerized complex BIS -2-Pyridyl--3--1- 2- 4-Triazolyl- propane and 11-Hydroxy-1- 1-Ethylidenediphosphonic acid
[paragraph_crop] => Bioscreening of the spacerized complex BIS (2-Pyridyl)-3-(1, 2, 4-Triazolyl) propane and [...]
[image_presente] =>
[date] => 2019-12-01 00:00:00
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[id_prestablog_categorie] => 24
[title] => Cross-disciplinary subjects
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[title] => Toxicology
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[id] => 1150
[url] => https://bioseb.com/en/news/effect-of-1-hydroxy-1-1-ethylidendiphosphone-acid--bis-2-pyridyl-1-2-4-triazolyl-3-propane-and-their-adduct-on-the-pain-sensitivity-of-rats-pyridyl-1-2-4-triazolyl-3-propane-and-their-adduct-on-the-pain-sensitivity-of-rats-n1150
[title] => EFFECT OF 1-HYDROXY-1-1-ETHYLIDENDIPHOSPHONE ACID- BIS-2-PYRIDYL-1-2-4-TRIAZOLYL-3-PROPANE AND THEIR ADDUCT ON THE PAIN SENSITIVITY OF RATS PYRIDYL-1-2-4-TRIAZOLYL-3-PROPANE AND THEIR ADDUCT ON THE PAIN SENSITIVITY OF RATS
[paragraph_crop] => EFFECT OF 1-HYDROXY-1,1-ETHYLIDENDIPHOSPHONE ACID, BIS(2-PYRIDYL-1,2,4-TRIAZOLYL-3)PROPANE AND [...]
[image_presente] =>
[date] => 2019-08-01 00:00:00
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[id_prestablog_categorie] => 36
[title] => Mechanical allodynia & Hyperlagesia
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[title] => Pain
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[url] => https://bioseb.com/en/news/effect-of-1-hydroxy-1-1-thylidendiphosphone-acid--bis-2-pyridyl-1-2-4-triazolyl-3-propane-and-their-adduct-on-the-pain-sensitivty-of-rats-n1156
[title] => Effect of 1-Hydroxy-1-1-thylidendiphosphone Acid- Bis-2-Pyridyl-1-2-4-Triazolyl-3-Propane and their adduct on the pain sensitivty of Rats
[paragraph_crop] => Effect of 1-Hydroxy-1,1-thylidendiphosphone Acid, Bis(2-Pyridyl-1,2,4-Triazolyl-3)Propane and [...]
[image_presente] =>
[date] => 2019-07-01 00:00:00
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[id_prestablog_categorie] => 27
[title] => General pain
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[1140] => Array
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[id] => 1140
[url] => https://bioseb.com/en/news/cerebral-expression-of-glial-fibrillary-acidic-protein--ubiquitin-carboxy-terminal-hydrolase-l1--and-matrix-metalloproteinase-9-after-traumatic-brain-injury-and-secondary-brain-insults-in-rats-n1140
[title] => Cerebral Expression of Glial Fibrillary Acidic Protein- Ubiquitin Carboxy-Terminal Hydrolase-L1- and Matrix Metalloproteinase 9 After Traumatic Brain Injury and Secondary Brain Insults in Rats
[paragraph_crop] => Cerebral Expression of Glial Fibrillary Acidic Protein, Ubiquitin Carboxy-Terminal [...]
[image_presente] =>
[date] => 2019-04-25 00:00:00
[categories] => Array
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[43] => Array
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[id_prestablog_categorie] => 43
[title] => General neurodegeneration
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[12] => Array
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[title] => Neurodegeneration
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[id] => 1126
[url] => https://bioseb.com/en/news/the-guanine-nucleotide-exchange-factor--spata13--influences-social-behaviour-and-nocturnal-activity-n1126
[title] => The guanine nucleotide exchange factor- Spata13- influences social behaviour and nocturnal activity
[paragraph_crop] => The guanine nucleotide exchange factor, Spata13, influences social behaviour and nocturnal activity
[image_presente] =>
[date] => 2019-04-24 00:00:00
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[title] => Cross-disciplinary subjects
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[title] => Phenotyping
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[title] => Publications
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[id] => 1122
[url] => https://bioseb.com/en/news/effects-of-resveratrol-in-the-signaling-of-neuropathic-pain-involving-p2x3-in-the-dorsal-root-ganglion-of-rats-n1122
[title] => Effects of resveratrol in the signaling of neuropathic pain involving P2X3 in the dorsal root ganglion of rats
[paragraph_crop] => Effects of resveratrol in the signaling of neuropathic pain involving P2X3 in the dorsal root [...]
[image_presente] =>
[date] => 2019-04-15 00:00:00
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[title] => Neuropathic pain
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[url] => https://bioseb.com/en/news/huachansu-suppresses-trpv1-up-regulation-and-spinal-astrocyte-activation-to-prevent-oxaliplatin-induced-peripheral-neuropathic-pain-in-rats-n1084
[title] => Huachansu suppresses TRPV1 up-regulation and spinal astrocyte activation to prevent oxaliplatin-induced peripheral neuropathic pain in rats
[paragraph_crop] => Huachansu suppresses TRPV1 up-regulation and spinal astrocyte activation to prevent [...]
[image_presente] =>
[date] => 2019-01-05 00:00:00
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[title] => Neuropathic pain
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[title] => Publications
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[id] => 1093
[url] => https://bioseb.com/en/news/amylin--a-peptide-expressed-by-nociceptors--modulates-chronic-neuropathic-pain-n1093
[title] => Amylin- a peptide expressed by nociceptors- modulates chronic neuropathic pain
[paragraph_crop] => Amylin, a peptide expressed by nociceptors, modulates chronic neuropathic pain
[image_presente] =>
[date] => 2018-12-02 00:00:00
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[title] => Pain
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[1068] => Array
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[id] => 1068
[url] => https://bioseb.com/en/news/cinobufacini-protects-against-paclitaxel-induced-peripheral-neuropathic-pain-and-suppresses-trpv1-up-regulation-and-spinal-astrocyte-activation-in-rats-n1068
[title] => Cinobufacini protects against paclitaxel-induced peripheral neuropathic pain and suppresses TRPV1 up-regulation and spinal astrocyte activation in rats
[paragraph_crop] => Cinobufacini protects against paclitaxel-induced peripheral neuropathic pain and suppresses [...]
[image_presente] =>
[date] => 2018-12-01 00:00:00
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[title] => Cancer
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[title] => Cross-disciplinary subjects
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[title] => Hot & Cold Perception
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[title] => Publications
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[title] => Sensory system
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[id] => 1091
[url] => https://bioseb.com/en/news/increased-nociceptive-responses-in-streptozotocin-induced-diabetic-rats-and-the-related-expression-of-spinal-nr2b-subunit-of-n-methyl-d-aspartate-receptors-n1091
[title] => Increased Nociceptive Responses in Streptozotocin-Induced Diabetic Rats and the Related Expression of Spinal NR2B Subunit of N-methyl-D-aspartate Receptors
[paragraph_crop] => Increased Nociceptive Responses in Streptozotocin-Induced Diabetic Rats and the Related [...]
[image_presente] =>
[date] => 2018-11-01 00:00:00
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[title] => Diabetes, Insulin & Glucose
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[title] => Metabolism
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[title] => Publications
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[id] => 1062
[url] => https://bioseb.com/en/news/itch-induced-by-peripheral-mu-opioid-receptors-is-dependent-on-trpv1-expressing-neurons-and-alleviated-by-channel-activation-n1062
[title] => Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation
[paragraph_crop] => Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and [...]
[image_presente] =>
[date] => 2018-10-19 00:00:00
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[title] => Sensory system
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[title] => Somatosensory system
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[id] => 1082
[url] => https://bioseb.com/en/news/docking-and-pharmacodynamic-studies-on-hgat1-inhibition-activity-in-the-presence-of-selected-neuronal-and-astrocytic-inhibitors-n1082
[title] => Docking and pharmacodynamic studies on hGAT1 inhibition activity in the presence of selected neuronal and astrocytic inhibitors
[paragraph_crop] => Docking and pharmacodynamic studies on hGAT1 inhibition activity in the presence of selected [...]
[image_presente] =>
[date] => 2018-10-01 00:00:00
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[id_prestablog_categorie] => 27
[title] => General pain
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[title] => Pain
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[title] => Publications
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[id] => 1050
[url] => https://bioseb.com/en/news/induction-of-brain-nrf2-ho-1-pathway-and-antinociception-after-different-physical-training-paradigms-in-mice-n1050
[title] => Induction of brain Nrf2-HO-1 pathway and antinociception after different physical training paradigms in mice
[paragraph_crop] => Induction of brain Nrf2-HO-1 pathway and antinociception after different physical training [...]
[image_presente] =>
[date] => 2018-09-15 00:00:00
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[title] => Exercise & Endurance
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[title] => General pain
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[title] => Pain
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[title] => Publications
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[id] => 1048
[url] => https://bioseb.com/en/news/neuronal-specific-tubb3-is-not-required-for-normal-neuronal-function-but-is-essential-for-timely-axon-regeneration-n1048
[title] => Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration
[paragraph_crop] => Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for [...]
[image_presente] =>
[date] => 2018-08-14 00:00:00
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[title] => Cross-disciplinary subjects
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[title] => Phenotyping
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[title] => Publications
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[1006] => Array
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[id] => 1006
[url] => https://bioseb.com/en/news/longitudinal-structural-and-functional-brain-network-alterations-in-a-mouse-model-of-neuropathic-pain-n1006
[title] => Longitudinal Structural and Functional Brain Network Alterations in a Mouse Model of Neuropathic Pain
[paragraph_crop] => Longitudinal Structural and Functional Brain Network Alterations in a Mouse Model of [...]
[image_presente] =>
[date] => 2018-04-20 00:00:00
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[title] => Chronic pain
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[title] => Mechanical allodynia & Hyperlagesia
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[title] => Neuropathic pain
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[title] => Pain
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[title] => Publications
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[id] => 923
[url] => https://bioseb.com/en/news/wider-range-of-allodynia-in-a-rat-model-of-repeated-dural-nociception-compared-with-infraorbital-nerve-chronic-constriction-injury-n923
[title] => Wider range of allodynia in a rat model of repeated dural nociception compared with infraorbital nerve chronic constriction injury
[paragraph_crop] => Wider range of allodynia in a rat model of repeated dural nociception compared with [...]
[image_presente] =>
[date] => 2018-02-18 00:00:00
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[title] => Inflammatory pain
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[title] => Neuropathic pain
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[title] => Pain
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[2] => Array
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[title] => Publications
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[987] => Array
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[id] => 987
[url] => https://bioseb.com/en/news/novel-analgesic-effects-of-melanin-concentrating-hormone-on-persistent-neuropathic-and-inflammatory-pain-in-mice-n987
[title] => Novel analgesic effects of melanin-concentrating hormone on persistent neuropathic and inflammatory pain in mice
[paragraph_crop] => Novel analgesic effects of melanin-concentrating hormone on persistent neuropathic and [...]
[image_presente] =>
[date] => 2018-01-15 00:00:00
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[id_prestablog_categorie] => 24
[title] => Cross-disciplinary subjects
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[title] => General pain
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[title] => Pain
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[title] => Phenotyping
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[2] => Array
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[id_prestablog_categorie] => 2
[title] => Publications
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[925] => Array
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[id] => 925
[url] => https://bioseb.com/en/news/inhibition-of-toll-like-receptor-4-alleviates-hyperalgesia-induced-by-acute-dural-inflammation-in-experimental-migraine-n925
[title] => Inhibition of toll-like receptor 4 alleviates hyperalgesia induced by acute dural inflammation in experimental migraine
[paragraph_crop] => Inhibition of toll-like receptor 4 alleviates hyperalgesia induced by acute dural inflammation [...]
[image_presente] =>
[date] => 2018-01-08 00:00:00
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[id_prestablog_categorie] => 48
[title] => Hot & Cold Perception
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[title] => Neuropathic pain
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[title] => Pain
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[title] => Publications
[link_rewrite] => publications
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[title] => Sensory system
[link_rewrite] => Sensory-system
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[922] => Array
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[id] => 922
[url] => https://bioseb.com/en/news/molecular-prerequisites-for-diminished-cold-sensitivity-in-ground-squirrels-and-hamsters-n922
[title] => Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters
[paragraph_crop] => Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters
[image_presente] =>
[date] => 2017-12-19 00:00:00
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[id_prestablog_categorie] => 48
[title] => Hot & Cold Perception
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[id_prestablog_categorie] => 25
[title] => Miscellaneous
[link_rewrite] => Miscellaneous
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[97] => Array
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[id_prestablog_categorie] => 97
[title] => Other animals
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[title] => Publications
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[title] => Sensory system
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[979] => Array
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[id] => 979
[url] => https://bioseb.com/en/news/potentiation-of-morphine-induced-antinociception-and-locomotion-by-citalopram-is-accompanied-by-anxiolytic-like-effects-n979
[title] => Potentiation of morphine-induced antinociception and locomotion by citalopram is accompanied by anxiolytic-like effects
[paragraph_crop] => Potentiation of morphine-induced antinociception and locomotion by citalopram is accompanied [...]
[image_presente] =>
[date] => 2017-10-10 00:00:00
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[title] => Anxiety
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[title] => Chronic pain
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[title] => Emotional pain
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[title] => Mood disorders
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[title] => Pain
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[title] => Publications
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[950] => Array
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[id] => 950
[url] => https://bioseb.com/en/news/brain-natriuretic-peptide-expressing-sensory-neurons-are-not-involved-in-acute--inflammatory--or-neuropathic-pain-n950
[title] => Brain natriuretic peptide-expressing sensory neurons are not involved in acute- inflammatory- or neuropathic pain
[paragraph_crop] => Brain natriuretic peptide-expressing sensory neurons are not involved in acute, inflammatory, [...]
[image_presente] =>
[date] => 2017-09-08 00:00:00
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[title] => Sensory system
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[912] => Array
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[id] => 912
[url] => https://bioseb.com/en/news/methods-used-to-evaluate-pain-behaviors-in-rodents-n912
[title] => Methods Used to Evaluate Pain Behaviors in Rodents
[paragraph_crop] => Methods Used to Evaluate Pain Behaviors in Rodents
[image_presente] =>
[date] => 2017-09-06 00:00:00
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[title] => General pain
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[title] => Pain
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[title] => Publications
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[title] => Spontaneous pain
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[951] => Array
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[id] => 951
[url] => https://bioseb.com/en/news/candesartan-prevents-resiniferatoxin-induced-sensory-small-fiber-neuropathy-in-mice-by-promoting-angiotensin-ii-mediated-at2-receptor-stimulation-n951
[title] => Candesartan prevents resiniferatoxin-induced sensory small-fiber neuropathy in mice by promoting angiotensin II-mediated AT2 receptor stimulation
[paragraph_crop] => Candesartan prevents resiniferatoxin-induced sensory small-fiber neuropathy in mice by [...]
[image_presente] =>
[date] => 2017-09-05 00:00:00
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[title] => Hot & Cold Perception
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[title] => Neuropathic pain
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[2] => Array
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[title] => Publications
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[title] => Sensory system
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[909] => Array
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[id] => 909
[url] => https://bioseb.com/en/news/antinociceptive-and-antipyretic-properties-of-ethanol-extract-of-oryza-bathii--poaceae--in-wistar-rats-n909
[title] => Antinociceptive and antipyretic properties of ethanol extract of Oryza bathii -Poaceae- in wistar rats
[paragraph_crop] => Antinociceptive and antipyretic properties of ethanol extract of Oryza bathii (Poaceae) in w [...]
[image_presente] =>
[date] => 2017-08-01 00:00:00
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[title] => General pain
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[36] => Array
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[title] => Mechanical allodynia & Hyperlagesia
[link_rewrite] => Mechanical-allodynia-hyperlagesia
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[title] => Pain
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[2] => Array
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[title] => Publications
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[907] => Array
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[id] => 907
[url] => https://bioseb.com/en/news/voluntary-and-evoked-behavioral-correlates-in-neuropathic-pain-states-under-different-social-housing-conditions-n907
[title] => Voluntary and evoked behavioral correlates in neuropathic pain states under different social housing conditions
[paragraph_crop] => Voluntary and evoked behavioral correlates in neuropathic pain states under different social [...]
[image_presente] =>
[date] => 2017-06-15 00:00:00
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[title] => Miscellaneous research domains
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[title] => Publications
[link_rewrite] => publications
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[908] => Array
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[id] => 908
[url] => https://bioseb.com/en/news/a-clinical-and-mechanistic-study-of-topical-borneol-induced-analgesia-n908
[title] => A clinical and mechanistic study of topical borneol-induced analgesia
[paragraph_crop] => A clinical and mechanistic study of topical borneol-induced analgesia
[image_presente] =>
[date] => 2017-06-01 00:00:00
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[title] => General pain
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[title] => Mechanical allodynia & Hyperlagesia
[link_rewrite] => Mechanical-allodynia-hyperlagesia
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[10] => Array
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[title] => Pain
[link_rewrite] => Pain
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[33] => Array
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[title] => Postoperative pain
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[2] => Array
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[title] => Publications
[link_rewrite] => publications
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[id] => 1071
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[title] => Decreased alertness due to sleep loss increases pain sensitivity in mice
[paragraph_crop] => Decreased alertness due to sleep loss increases pain sensitivity in mice
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[title] => Genetic ablation of GINIP-expressing primary sensory neurons strongly impairs Formalin-evoked pain-
[paragraph_crop] => Genetic ablation of GINIP-expressing primary sensory neurons strongly impairs Formalin-evoked pain.
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[title] => Effect of Tualang -Apis dorsata- Honey on Development of Morphine Tolerance in Rats
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[title] => Evaluation of Postoperative Anti-nociceptive Efficacy of Intrathecal Dexketoprofen in Rats
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[title] => Modulation of Disulfide Dual ENKephalinase Inhibitors -DENKIs- Activity by a Transient N-protection for Pain Alleviation by Oral Route
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[url] => https://bioseb.com/en/news/the-nav1--9-channel-is-a-key-determinant-of-cold-pain-sensation-and-cold-allodynia-n778
[title] => The Nav1- 9 Channel Is a Key Determinant of Cold Pain Sensation and Cold Allodynia
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[date] => 2015-05-19 00:00:00
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[url] => https://bioseb.com/en/news/the-low-threshold-calcium-channel-cav3-2-determines-low-threshold-mechanoreceptor-function-n655
[title] => The Low-Threshold Calcium Channel Cav3-2 Determines Low-Threshold Mechanoreceptor Function
[paragraph_crop] => The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function
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[date] => 2015-01-20 00:00:00
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[url] => https://bioseb.com/en/news/oligodendrocyte-ablation-triggers-central-pain-independently-of-innate-or-adaptive-immune-responses-in-mice-n676
[title] => Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice
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[date] => 2014-12-01 00:00:00
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[title] => Neuroprotective Effect of Erythropoietin against Pressure Ulcer in a Mouse Model of Small Fiber Neuropathy
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[title] => Antiallodynic and antihyperalgesic activity of 3-[4--3-trifluoromethyl-phenyl--piperazin-1-yl]-dihydrofuran-2-one compared to pregabalin in chemotherapy-induced neuropathic pain in mice-
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[title] => Antiallodynic and antihyperalgesic activity of 3-[4--3-trifluoromethyl-phenyl--piperazin-1-yl]-dihydrofuran-2-one compared to pregabalin in chemotherapy-induced neuropathic pain in mice-
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[title] => Morphine glucuronidation increases its analgesic effect in guinea pigs
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[date] => 2014-06-23 00:00:00
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[date] => 2014-05-02 00:00:00
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[title] => Assessment of thermal sensitivity in rats using the thermal place preference test- description and application in the study of oxaliplatin-induced acute thermal hypersensitivity and inflammatory pain models-
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[title] => Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat- Analgesic activity of pregabalin- tramadol and duloxetine
[paragraph_crop] => Face-to-face comparison of the predictive validity of two models of neuropathic pain in the [...]
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[title] => Studying ongoing and spontaneous pain in rodents – challenges and opportunities
[paragraph_crop] => Studying ongoing and spontaneous pain in rodents – challenges and opportunities
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[date] => 2014-04-01 00:00:00
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[title] => The influence of spatial pulsed magnetic field application on neuropathic pain after tibial nerve transection in rat
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[date] => 2014-03-31 00:00:00
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[title] => Mice with a deletion of the major central myelin protein exhibit hypersensitivity to noxious thermal stimuli- involvement of central sensitization
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[url] => https://bioseb.com/en/news/a-polyamine-deficient-diet-prevents-oxaliplatin-induced-acute-cold-and-mechanical-hypersensitivity-in-rats-n499
[title] => A Polyamine-Deficient Diet Prevents Oxaliplatin-Induced Acute Cold and Mechanical Hypersensitivity in Rats
[paragraph_crop] => A Polyamine-Deficient Diet Prevents Oxaliplatin-Induced Acute Cold and Mechanical [...]
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[title] => Mu Opioid Receptors on Primary Afferent Nav1-8 Neurons Contribute to Opiate-Induced Analgesia- Insight from Conditional Knockout Mice
[paragraph_crop] => Mu Opioid Receptors on Primary Afferent Nav1.8 Neurons Contribute to Opiate-Induced Analgesia: [...]
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[title] => Opiates Modulate Thermosensation by Internalizing Cold Receptor TRPM8
[paragraph_crop] => Opiates Modulate Thermosensation by Internalizing Cold Receptor TRPM8
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[url] => https://bioseb.com/en/news/p2x7-cell-death-receptor-activation-and-mitochondrial-impairment-in-oxaliplatin-induced-apoptosis-and-neuronal-injury--cellular-mechanisms-and-in-vivo-approach--n556
[title] => P2X7 Cell Death Receptor Activation and Mitochondrial Impairment in Oxaliplatin-Induced Apoptosis and Neuronal Injury- Cellular Mechanisms and In Vivo Approach
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[url] => https://bioseb.com/en/news/evaluation-of-cebranopadol--a-dually-acting-nociceptin-and-orphanin-fq-and-opioid-receptor-agonist-in-mouse-models-of-acute--tonic--and-chemotherapy-induced-neuropathic-pain-n920
[title] => Evaluation of cebranopadol- a dually acting nociceptin and orphanin FQ and opioid receptor agonist in mouse models of acute- tonic- and chemotherapy-induced neuropathic pain
[paragraph_crop] => Evaluation of cebranopadol, a dually acting nociceptin/orphanin FQ and opioid receptor agonist [...]
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[url] => https://bioseb.com/en/news/anticancer-activity-of-methyl-substituted-oxaliplatin-analog---n403
[title] => Anticancer Activity of Methyl-substituted Oxaliplatin Analog-
[paragraph_crop] => Anticancer Activity of Methyl-substituted Oxaliplatin Analog.
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[url] => https://bioseb.com/en/news/gq-and-11-signaling-tonically-modulates-nociceptor-function-and-contributes-to-activity-dependent-sensitization---n368
[title] => G_q and 11 signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization-
[paragraph_crop] => G_q/11 signaling tonically modulates nociceptor function and contributes to activity-dependent [...]
[image_presente] =>
[date] => 2012-01-08 00:00:00
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[url] => https://bioseb.com/en/news/bidirectional-integrative-regulation-of-cav1-2-calcium-channel-by-microrna-mir-103--role-in-pain--n336
[title] => Bidirectional integrative regulation of Cav1-2 calcium channel by microRNA miR-103- role in pain-
[paragraph_crop] => Bidirectional integrative regulation of Cav1.2 calcium channel by microRNA miR-103: role in pain.
[image_presente] =>
[date] => 2011-07-29 00:00:00
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[title] => Spinal Cord
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[url] => https://bioseb.com/en/news/oxaliplatin-induced-cold-hypersensitivity-is-due-to-remodelling-of-ion-channel-expression-in-nociceptors---n321
[title] => Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors-
[paragraph_crop] => Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in [...]
[image_presente] =>
[date] => 2011-05-24 00:00:00
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[306] => Array
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[id] => 306
[url] => https://bioseb.com/en/news/characterisation-of-sensory-abnormalities-observed-in-an-animal-model-of-multiple-sclerosis--a-behavioural-and-pharmacological-study---n306
[title] => Characterisation of sensory abnormalities observed in an animal model of multiple sclerosis- A behavioural and pharmacological study-
[paragraph_crop] => Characterisation of sensory abnormalities observed in an animal model of multiple sclerosis: A [...]
[image_presente] =>
[date] => 2011-03-09 00:00:00
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[title] => Mechanical allodynia & Hyperlagesia
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[304] => Array
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[id] => 304
[url] => https://bioseb.com/en/news/trpv1-lineage-neurons-are-required-for-thermal-sensation--n304
[title] => TRPV1-lineage neurons are required for thermal sensation-
[paragraph_crop] => TRPV1-lineage neurons are required for thermal sensation.
[image_presente] =>
[date] => 2011-02-02 00:00:00
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[url] => https://bioseb.com/en/news/dissecting-the-functional-significance-of-endothelin-a-receptors-in-peripheral-nociceptors-in-vivo-via-conditional-gene-deletion---n249
[title] => Dissecting the functional significance of endothelin A receptors in peripheral nociceptors in vivo via conditional gene deletion-
[paragraph_crop] => Dissecting the functional significance of endothelin A receptors in peripheral nociceptors in [...]
[image_presente] =>
[date] => 2010-02-28 00:00:00
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[url] => https://bioseb.com/en/news/differentiating-thermal-allodynia-and-hyperalgesia-using-dynamic-hot-and-cold-plate-in-rodents--n224
[title] => Differentiating Thermal Allodynia and Hyperalgesia Using Dynamic Hot and Cold Plate in Rodents-
[paragraph_crop] => Differentiating Thermal Allodynia and Hyperalgesia Using Dynamic Hot and Cold Plate in Rodents.
[image_presente] =>
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[id] => 201
[url] => https://bioseb.com/en/news/the-mechano-activated-k-channels-traak-and-trek-1-control-both-warm-and-cold-perception--n201
[title] => The mechano-activated K channels TRAAK and TREK-1 control both warm and cold perception-
[paragraph_crop] => The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception.
[image_presente] =>
[date] => 2009-05-06 00:00:00
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[url] => https://bioseb.com/en/news/the-mechano-activated-k-channels-traak-and-trek-1-control-both-warm-and-cold-perception-n625
[title] => The mechano-activated K channels TRAAK and TREK-1 control both warm and cold perception
[paragraph_crop] => The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception
[image_presente] =>
[date] => 2009-05-06 00:00:00
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[title] => Publications
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[id] => 187
[url] => https://bioseb.com/en/news/asic3--a-sensor-of-acidic-and-primary-inflammatory-pain--n187
[title] => ASIC3- a sensor of acidic and primary inflammatory pain-
[paragraph_crop] => ASIC3, a sensor of acidic and primary inflammatory pain.
[image_presente] =>
[date] => 2008-11-19 00:00:00
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1Number of publications:
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Cold Hot Plate Test
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