Thermal Gradient Test

Reference: BIO-GRADIENT

The operator-independant Thermal Gradient Test is a new analgesia/nociceptive research instrument to demonstrate place preference / temperature comfort threshold on rodents (mouse and rat) freely moving on a plate offering a temperature gradient - an innovative tool for analgesic drug screening and research on thermal nociception.

Instrument for ratsInstrument for mice

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Bioseb
Thermal Gradient Test: Software screenshot

Bioseb’s operator-independant Thermal Gradient Test is a new analgesia/nociceptive research instrument to demonstrate place preference and temperature comfort threshold on rodents (mouse and rat) freely moving on a long plate offering a stable temperature gradient between two compartments.

As advised by A. MOQRICH, and published in Moqrich et al (Science 2005, 307: 1468-72), the Thermal Gradient Test, like the Thermal Place Preference test, allows researchers to work on unrestrained animals (mice and rats) let free to choose their preferred position (comfort zone) between 2 compartments set at different temperatures. This behavioural assay will allow monitoring temperature preferences, nociceptive thresholds and state in the role of a given gene or a compound on these pain thresholds associated to cold and hot stimulation.

The Thermal Gradient Test, unlike the cold/hot plate test, is one of the very few thermal nociception tests to be operator-independant on freely moving rodents (mice and rat). The 'Thermal Gradient Test' will return a nociceptive response without any action from the operator, and the obtained value is a temperature range corresponding to the comfort zone of the animal (rat or mouse), and indicating its sensitivity resulting to the exposure to different stimulations (cold or heat).

Bioseb’s Thermal Gradient Test is ideal for your research on analgesia and nociception, and especially suitable for studies on alodynia.

icone-oper.gifOperating principle

Using the included controls on the the electronic console, a continuous and stable temperature gradient (5 to 55°C) is established over a 120 cm long base plate, on which the animal is free to walk in an unrestrained manner.

Following the exploration period, the rodent (mouse or rat) shows a distinct zone preference, or comfort zone, which is an indication of his level of thermal sensitivity, and which can be determined by mesuring the time spent by the rodent in each of the 20 different temperature zones which can be set using the software.

The Gradient test allow to work independently and simultaneously with 2 mice (or small rats) or 1 adult rat.

Product Details

BIO-GRADIENT

Data sheet

Accuracy
1°C
Data output
xls type, presented per time periods. Raw datas encrypted (glp) with video recording (synchronous). Replay: at any time
Materials
Base Plate: Aluminum alloy Cover: Transparent ppc Walls: Grey ppc
Number of animals
Mouse: 2 / Rat: 1
Power supply
220 / 110 Volts
Range
5 to 55 °C
Software
Allows to measure per animal: up to 20 temperature zones, time spent/temp.Zone/ time period, overall distance travelled.

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