Alterations of voluntary behavior in the course of disease progress and pharmacotherapy in mice with collagen-induced arthritis

Authors
Y Oto, Y Takahashi, D Kurosaka, F Kato

Lab
Center for Neuroscience of Pain, Jikei University School of Medicine, Minato-ku, Tokyo, Japan

Journal
Arthritis Research & Therapy

Abstract
We described for the first time significant alterations of the voluntary behavior of the mice with CIA during the clinical periods, indicating that the overall physical/motivational states and its circadian variation, as well as the specific preference to a certain environmental temperature, are modified in the mice with CIA, as observed in human patients. Some of these did not parallel with the conventional arthritis scores, particularly during the pharmacotherapy suggesting that mice with CIA show not only the peripheral symptoms but also the central consequences. The use of these approaches would also help clarify the biological mechanisms underlying physician-patient discordance in the assessment of RA.

BIOSEB Instruments Used:
Thermal Place Preference, 2 Temperatures Choice Nociception Test (BIO-T2CT)