Bioscreening of the spacerized complex BIS -2-Pyridyl--3--1- 2- 4-Triazolyl- propane and 11-Hydroxy-1- 1-Ethylidenediphosphonic acid
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E Chuyan, M Ravaeva, I Cheretaev, O Kornilenko

Taurida Academy, V.I. Vernadsky Crimean Federal University, Simferopol, Russia

Advances in Biological Sciences Research,

Scientific work is devoted to the study of the biological activity spacerized complex bis(2-Pyridyl) -3- (1,2,4-Triazolyl) Propane And 11-Hydroxy-1,1-Ethylidenediphosphonic Acid in the dose range from 5 to 200 mg / kg. The results of the study of acute toxicity showed that spacering of the HDA+BTP complex reduces its toxicity by 1.4 times in comparison with characteristics of its precursor components. It was found that the test compound exhibits a dose-dependent hypotensive and vasorelaxating effect, sedative, anxiogenic and analgesic effects.

BIOSEB Instruments Used:
Cold Hot Plate Test (BIO-CHP),Rodent pincher - analgesia meter (BIO-RP-M)

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