Bioscreening of the spacerized complex BIS -2-Pyridyl--3--1- 2- 4-Triazolyl- propane and 11-Hydroxy-1- 1-Ethylidenediphosphonic acid
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Authors
E Chuyan, M Ravaeva, I Cheretaev, O Kornilenko


Lab
Taurida Academy, V.I. Vernadsky Crimean Federal University, Simferopol, Russia

Journal
Advances in Biological Sciences Research,

Abstract
Scientific work is devoted to the study of the biological activity spacerized complex bis(2-Pyridyl) -3- (1,2,4-Triazolyl) Propane And 11-Hydroxy-1,1-Ethylidenediphosphonic Acid in the dose range from 5 to 200 mg / kg. The results of the study of acute toxicity showed that spacering of the HDA+BTP complex reduces its toxicity by 1.4 times in comparison with characteristics of its precursor components. It was found that the test compound exhibits a dose-dependent hypotensive and vasorelaxating effect, sedative, anxiogenic and analgesic effects.

BIOSEB Instruments Used:
Cold Hot Plate Test (BIO-CHP),Rodent pincher - analgesia meter (BIO-RP-M)

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