Delta Opioid Receptor in Astrocytes Contributes to Neuropathic Cold Pain and Analgesic Tolerance in Female Mice

Authors
D Reiss, H Maurin, E Audouard et al

Lab
UniversitŽ de Strasbourg, Institut de GŽnŽtique et de Biologie MolŽculaire et Cellulaire, Illkirch, France

Journal
Frontiers in Cellular Neuroscience

Abstract
The delta opioid receptor (DOR) contributes to pain control, and a major challenge is the identification of DOR populations that control pain, analgesia, and tolerance. Astrocytes are known as important cells in the pathophysiology of chronic pain, and many studies report an increased prevalence of pain in women. However, the implication of astrocytic DOR in neuropathic pain and analgesia, as well as the influence of sex in this receptor activity, remains unknown.

BIOSEB Instruments Used:
Von Frey Filaments (Bio-VF-M)