INFLUENCE OF 1-HYDROXY-1-1-ETHYLIDENDIPHOSPHONE ACID AND BIS -2-PYRIDYL-1-2-4-TRIAZOLYL-3- PROPANE ON PAIN SENSITIVITY OF RAT FEMALES

Authors
IV Cheretaev, EN Chuyan, MY Ravaeva, VF Shulgin

Lab
Tavrida Academy (structural unit) FSAEI of HE, V.I. Vernadsky Crimean Federal University, Simferopol, Russia

Journal
International Research Journal

Abstract
The paper presents the results of studying the effect of 1-hydroxy-1,1-ethylidene diphosphonic acid and bis(2-pyridyl-1,2,4-triazolyl-3) propane with doses of 5, 50, 100 and 200 mg/kg on the pain sensitivity of rat females. The experiments were conducted on 100 Wistar female rats on acute thermal (tail-flick, hot plate) and mechanical pain test models (Randall-Selitto test). It was found that 1-hydroxy-1,1-ethylidene diphosphonic acid has a clear analgesic effect with thermal effects in doses of 5 and 200 mg/kg, and mechanical pain effects with a dose of 50 mg/kg; bis (2-pyridyl-1,2,4-triazolyl-3) propane in the tail-flick test with doses of 5 and 50 mg/kg, in the hot plate test, with the dose of 50 mg/kg, in the Randall-Selittto test, with a dose of 50 mg/kg.

BIOSEB Instruments Used:
Rodent pincher - analgesia meter (BIO-RP-M)