IV Cheretaev, EN Chuyan, MY Ravaeva, VF Shulgin
Tavrida Academy (structural unit) FSAEI of HE, V.I. Vernadsky Crimean Federal University, Simferopol, Russia
International Research Journal
The paper presents the results of studying the effect of 1-hydroxy-1,1-ethylidene diphosphonic acid and bis(2-pyridyl-1,2,4-triazolyl-3) propane with doses of 5, 50, 100 and 200 mg/kg on the pain sensitivity of rat females. The experiments were conducted on 100 Wistar female rats on acute thermal (tail-flick, hot plate) and mechanical pain test models (Randall-Selitto test). It was found that 1-hydroxy-1,1-ethylidene diphosphonic acid has a clear analgesic effect with thermal effects in doses of 5 and 200 mg/kg, and mechanical pain effects with a dose of 50 mg/kg; bis (2-pyridyl-1,2,4-triazolyl-3) propane in the tail-flick test with doses of 5 and 50 mg/kg, in the hot plate test, with the dose of 50 mg/kg, in the Randall-Selittto test, with a dose of 50 mg/kg.
BIOSEB Instruments Used:
Rodent pincher - analgesia meter (BIO-RP-M)