Inhibition of endothelin A receptor by a novel- selective receptor antagonist enhances morphine-induced analgesia- Possible functional interaction of dimerized endothelin A and mu-opioid receptors
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Authors
Y Kurodaab,M Nonakab, Y Kamikubo et al


Lab
The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.

Journal
Biomedicine & Pharmacotherapy

Abstract
The misuse of opioids has led to an epidemic in recent times. The endothelin A receptor (ETAR) has recently attracted attention as a novel therapeutic target to enhance opioid analgesia. We hypothesized that endothelin A receptors may affect pain mechanisms by heterodimerization with mu-opioid receptors. We examined the mechanisms of ETAR-mediated pain and the potential therapeutic effects of an ETAR antagonist, Compound-E, as an agent for analgesia.

BIOSEB Instruments Used:
Rodent pincher - analgesia meter (BIO-RP-M)

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